SUMO3 and STAB2

Number of citations of the paper that reports this interaction (PMID 14701874)
53

Data Source:
BioGRID (enzymatic study)

		SUMO3	STAB2
Gene Name		small ubiquitin-like modifier 3	stabilin 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Endocytic Vesicle Membrane
	Molecular Function	Protein Binding SUMO Transferase Activity	Low-density Lipoprotein Receptor Activity Scavenger Receptor Activity Protein Binding Hyaluronic Acid Binding Protein Disulfide Oxidoreductase Activity Low-density Lipoprotein Particle Binding
	Biological Process	Protein Sumoylation Protein Localization To Nucleus Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process	Angiogenesis Carbohydrate Metabolic Process Endocytosis Receptor-mediated Endocytosis Cell Adhesion Pathogenesis Regulation Of Gene Expression Regulation Of Blood Coagulation Glycosaminoglycan Metabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Defense Response To Bacterium Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		SUMO is proteolytically processed Post-translational protein modification SUMOylation SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) Processing and activation of SUMO	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism Hyaluronan uptake and degradation Defective CHST14 causes EDS, musculocontractural type Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Hyaluronan metabolism MPS IIID - Sanfilippo syndrome D Defective CHST6 causes MCDC1 MPS IIIC - Sanfilippo syndrome C Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A Scavenging by Class H Receptors MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS			Coronary restenosis ( 21878436) vWF and FVIII levels ( 21810271)
Protein-Protein Interactions		53 interactors: ANXA7 ARL13A ARNTL ATF3 ATF7IP BCL11A BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 FOS HSF1 HSF2 JUN KALRN KCNA5 KRT14 KRT5 KRT8 MAPKAPK3 NFKBIA PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 SAE1 SATB1 SENP1 SENP2 SENP5 SH3KBP1 SMN1 SOX10 SOX6 SP100 STAB2 STK24 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USPL1 VIM	2 interactors: SUMO1 SUMO3
Entrez ID		6612	55576
HPRD ID		03754	10542
Ensembl ID		ENSG00000184900	ENSG00000136011
Uniprot IDs		B4DUW4 P55854	Q8WWQ8
PDB IDs		1U4A 2IO1
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Positive Regulation Of Metabolic Process Peptidyl-lysine Modification Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Cellular Metabolic Process Regulation Of Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Stimulus Negative Regulation Of Transcription From RNA Polymerase II Promoter Anatomical Structure Development Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Transcription, DNA-templated Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein Desumoylation Cellular Metabolic Process Apoptotic Signaling Pathway RNA Biosynthetic Process Peptidyl-amino Acid Modification Developmental Process Apoptotic Process Programmed Cell Death Viral Process Transcription From RNA Polymerase II Promoter Cell Death Death RNA Metabolic Process Multicellular Organismal Development Response To Abiotic Stimulus System Development Regulation Of Cellular Process Cellular Response To Stimulus Cellular Response To Stress Regulation Of Cell Cycle Cellular Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process	Protein Sumoylation Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of Cellular Protein Catabolic Process Protein Localization To Nucleus Post-translational Protein Modification Positive Regulation Of Protein Catabolic Process Peptidyl-lysine Modification Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process PML Body Organization Protein Localization To Nuclear Pore Protein Localization To Organelle Protein Localization To Nuclear Envelope Protein Modification By Small Protein Conjugation Regulation Of Proteolysis Peptidyl-amino Acid Modification Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Cellular Protein Localization Negative Regulation Of DNA Binding Nuclear Envelope Organization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Protein Localization Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA Binding Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Binding Regulation Of Protein Metabolic Process Palate Development Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleus Organization Interferon-gamma-mediated Signaling Pathway Cellular Localization Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Interferon-gamma Response To Interferon-gamma Positive Regulation Of Protein Complex Assembly Regulation Of Proteasomal Protein Catabolic Process Regulation Of Protein Ubiquitination Cellular Protein Modification Process Regulation Of Innate Immune Response Positive Regulation Of Metabolic Process Regulation Of Binding
Tagcloud ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation	0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 obscn plau ppp1ca prkdc resequencing rnf168 sanger sl slv smyth ubc ubiquitinylation vitiliginous vitiligo xirp1
Tagcloud (Difference) ?		aphidicolin attachment break breakage budding cfs covalent excessive fields fragile hallmark modifier ortholog perturbed pol32 pold3 polypeptides proteomic recombinational replication resource rpa ssdna stresses subfamily sumo1 sumo2 sumoylation	0x 1x adamts13 aspm atp6v0a2 bioinformatic bl chickens col12a1 fowl grm5 interpretations jungle lrp2 obscn plau ppp1ca prkdc resequencing rnf168 sanger sl slv smyth ubc ubiquitinylation vitiliginous vitiligo xirp1
Tagcloud (Intersection) ?