DOLK and KCNA10

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DOLK	KCNA10
Name		dolichol kinase	potassium voltage-gated channel subfamily A member 10
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	Dolichol Kinase Activity Protein Binding Kinase Activity Transferase Activity	Monoatomic Ion Channel Activity Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding
	Biological Process	Protein N-linked Glycosylation Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Synthesis of dolichyl-phosphate Defective DOLK causes DOLK-CDG	Voltage gated Potassium channels
Drugs		None	Enflurane Promethazine Miconazole Dalfampridine
Diseases		Congenital disorders of glycosylation (CDG) type I	None
GWAS		No GWAS studies recorded	Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome ( 31005965 ) Response to bupropion in depression ( 27622933 )
Interacting Genes		21 interacting genes: APPBP2 CD79A CHODL CREB3 CREB3L1 EDA FAM209A FNDC9 GALNT8 GJA8 GPX8 KCNA1 KCNA10 KCNA3 KCNA6 SLC7A6 SYNPR TMEM45B TMEM80 UBQLN1 VSIR	6 interacting genes: DOLK KCNA1 MAL POMP SGTA TMBIM6
Entrez ID		22845	3744
HPRD ID		15525	03882
Ensembl ID		ENSG00000175283	ENSG00000143105
Uniprot IDs		A0A0S2Z597 Q9UPQ8	Q16322
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Delayed Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Protein Homooligomerization Regulation Of Response To Endoplasmic Reticulum Stress Protein Complex Oligomerization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway L-lysine:L-arginine Antiporter Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Collagen Catabolic Process Regulation Of Collagen Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway	Endoplasmic Reticulum Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Insertion Into Membrane Negative Regulation Of Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Dolichol Kinase Activity Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Endoribonuclease Inhibitor Activity Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Localization To Paranode Region Of Axon Membrane Raft Polarization BAT3 Complex Binding Dolichol Phosphate Mannose Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Neuronal Signal Transduction Cellular Response To Magnesium Ion Membrane Raft Distribution Establishment Of Protein Localization To Membrane Peptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of ERAD Pathway Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Membrane Raft Localization Response To Endoplasmic Reticulum Stress Juxtaparanode Region Of Axon Paranode Region Of Axon Magnesium Ion Homeostasis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Membrane Protein Localization To Axon Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Negative Regulation Of Cellular Response To Hypoxia IRE1-mediated Unfolded Protein Response Negative Regulation Of Immunoglobulin Production Proteasome Assembly Apical Protein Localization Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Cytosolic Calcium Ion Concentration Response To Magnesium Ion Startle Response Positive Regulation Of ERAD Pathway