DOLK and SLC7A6

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		DOLK	SLC7A6
Name		dolichol kinase	solute carrier family 7 member 6
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Dolichol Kinase Activity Protein Binding Kinase Activity Transferase Activity	Protein Binding Amino Acid Transmembrane Transporter Activity Basic Amino Acid Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity Antiporter Activity Transmembrane Transporter Activity Arginine Binding L-arginine Transmembrane Transporter Activity L-lysine:L-arginine Antiporter Activity
	Biological Process	Protein N-linked Glycosylation Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process	Amino Acid Transmembrane Transport Nitric Oxide Biosynthetic Process Amino Acid Transport Neutral Amino Acid Transport L-leucine Transport Ornithine Transport Glycine Betaine Transport Transmembrane Transport L-lysine Transmembrane Transport L-arginine Transmembrane Transport
Pathways		Synthesis of dolichyl-phosphate Defective DOLK causes DOLK-CDG	Basigin interactions Amino acid transport across the plasma membrane
Diseases		Congenital disorders of glycosylation (CDG) type I	None
GWAS		No GWAS studies recorded	Body mass index ( 28552196 ) Estimated glomerular filtration rate ( 30604766 31152163 ) Glomerular filtration rate (creatinine) ( 26831199 28452372 ) Metabolic traits ( 21886157 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 30285260 ) Serum metabolite levels ( 23093944 33031748 )
Interacting Genes		21 interacting genes: APPBP2 CD79A CHODL CREB3 CREB3L1 EDA FAM209A FNDC9 GALNT8 GJA8 GPX8 KCNA1 KCNA10 KCNA3 KCNA6 SLC7A6 SYNPR TMEM45B TMEM80 UBQLN1 VSIR	1 interacting genes: DOLK
Entrez ID		22845	9057
HPRD ID		15525	12031
Ensembl ID		ENSG00000175283	ENSG00000103064
Uniprot IDs		A0A0S2Z597 Q9UPQ8	Q92536
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Membrane Delayed Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Protein Homooligomerization Regulation Of Response To Endoplasmic Reticulum Stress Protein Complex Oligomerization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway L-lysine:L-arginine Antiporter Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Collagen Catabolic Process Regulation Of Collagen Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway	Dolichol Kinase Activity Dolichol Phosphate Mannose Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Isoprenoid Biosynthetic Process Glycolipid Metabolic Process Terpenoid Metabolic Process Isoprenoid Metabolic Process Glycolipid Biosynthetic Process Protein N-linked Glycosylation Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Phospholipid Metabolic Process