DLG1 and ATP2B2

Number of citations: 0 (PubMedID 11274188)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		DLG1	ATP2B2
Name		discs large MAGUK scaffold protein 1	ATPase plasma membrane Ca2+ transporting 2
Structure			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Basement Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Neuron Projection Lateral Loop Membrane Raft Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction MPP7-DLG1-LIN7 Complex Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Cytoplasm Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Dendritic Spine Membrane Intracellular Membrane-bounded Organelle Synapse Extracellular Exosome Postsynaptic Density Membrane Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	GMP Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Kinase Binding Protein Kinase Binding Phosphatase Binding Ionotropic Glutamate Receptor Binding Transmembrane Transporter Binding Cadherin Binding Molecular Adaptor Activity L27 Domain Binding Structural Constituent Of Postsynaptic Density	Nucleotide Binding P-type Calcium Transporter Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding ATP Hydrolysis Activity PDZ Domain Binding Metal Ion Binding P-type Calcium Transporter Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Chemical Synaptic Transmission Nervous System Development Intracellular Protein Localization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Actin Filament Polymerization Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Astral Microtubule Organization Protein-containing Complex Localization Membrane Raft Organization Regulation Of Myelination Regulation Of Protein Localization Protein Localization To Synapse T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cortical Microtubule Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Reproductive Structure Development Embryonic Skeletal System Morphogenesis Tissue Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Establishment Of Centrosome Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hard Palate Development Negative Regulation Of ERK1 And ERK2 Cascade Bicellular Tight Junction Assembly Protein Localization To Membrane Protein Localization To Plasma Membrane Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Maintenance Of Postsynaptic Density Structure Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Sodium Ion Transmembrane Transport Regulation Of Protein Localization To Synapse Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Import Negative Regulation Of P38MAPK Cascade Regulation Of Potassium Ion Export Across Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Monoatomic Ion Transport Calcium Ion Transport Sensory Perception Of Sound Neuron Differentiation Monoatomic Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Transmembrane Transport Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Cardiac Conduction
Pathways		Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases
Drugs		None	Ritodrine Halothane Desflurane Sevoflurane
GWAS		Allergic rhinitis ( 25085501 ) Appendicular lean mass ( 33097823 ) Diastolic blood pressure ( 30224653 ) Heel bone mineral density ( 30598549 ) Metabolite levels ( 23823483 ) PR interval ( 32439900 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 31043756 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hip circumference adjusted for BMI ( 34021172 ) Manganese levels ( 26025379 ) Metabolite levels ( 19043545 )
Interacting Genes		81 interacting genes: ACTA1 ACTN2 ACVR2B ADAM17 ADGRA2 ADGRA3 ADGRB1 ADRB1 AKAP5 APC ARHGEF26 ATP2B2 ATP2B4 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRHR1 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 DSCAM EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GRIA1 GRIK2 GRIN1 GRIN2A GRIN2B GUCY1A2 HTR2A KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PAX6 PBK PRKN PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TIAM1 TJAP1 UBASH3A UBE3A WAS WNT3A	8 interacting genes: DLG1 DLG2 DLG4 ERBIN NHERF2 PDZD11 PRKCA SNTA1
Entrez ID		1739	491
HPRD ID		03007	00160
Ensembl ID		ENSG00000075711	ENSG00000157087
Uniprot IDs		A0A0C4DFT3 A0A590UJ08 A0A590UJ68 A0A590UJD9 A0A590UJX2 A0A590UK48 A0A590UKA8 B4DF78 Q12959	A0A2U3U055 Q01814
PDB IDs		1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69 7PC3 8CN1 8CN3	Not available
GO Terms Enriched among Interactors		Synapse Glutamatergic Synapse Plasma Membrane Modulation Of Chemical Synaptic Transmission Postsynaptic Density Metal Ion Transport PDZ Domain Binding Regulation Of Membrane Potential Monoatomic Ion Channel Complex Postsynaptic Density Membrane Monoatomic Cation Transport Monoatomic Ion Transport Regulation Of Monoatomic Ion Transport Dendritic Spine Dendrite Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Voltage-gated Potassium Channel Complex System Process Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Inorganic Ion Transmembrane Transport Regulation Of Synaptic Plasticity Regulation Of System Process Regulation Of Transport Regulation Of Signaling Regulation Of Cell Communication Transmembrane Transport Cell Projection Monoatomic Ion Channel Activity Neuron Projection Postsynaptic Membrane Nervous System Process Positive Regulation Of Synaptic Transmission Action Potential Regulation Of Multicellular Organismal Process Potassium Ion Transmembrane Transport Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Potassium Ion Transport Membrane Trans-synaptic Signaling Synaptic Signaling Regulation Of Postsynaptic Membrane Potential Cell-cell Junction Modulation Of Excitatory Postsynaptic Potential Signal Transduction Axon Signaling	Neuromuscular Junction Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Ionotropic Glutamate Receptor Binding Establishment Or Maintenance Of Cell Polarity Adherens Junction Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Basolateral Plasma Membrane GMP Kinase Activity Protein Localization To Cell Junction Protein Localization To Membrane GDP Metabolic Process Kinase Binding Postsynaptic Density Membrane Juxtaparanode Region Of Axon Cell Adhesion Cellular Response To Potassium Ion Anchoring Junction Plasma Membrane Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Response To Potassium Ion Localization Within Membrane Regulation Of System Process GMP Metabolic Process Cell Junction Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Protein Localization To Cell Periphery Regulation Of Sodium Ion Transmembrane Transport Postsynaptic Density Regulation Of Biological Quality Phosphatase Binding Chemical Synaptic Transmission Synaptic Membrane Lateral Plasma Membrane Neuron Projection Trans-synaptic Signaling Synaptic Signaling Protein-containing Complex Localization Regulation Of Sodium Ion Transport P2Y1 Nucleotide Receptor Binding Intracellular Protein Localization Nucleoside Monophosphate Metabolic Process Ribonucleoside Diphosphate Metabolic Process Voltage-gated Potassium Channel Complex Nucleoside Diphosphate Metabolic Process Membrane