DLG1 and WNT3A

Number of citations of the paper that reports this interaction (PubMedID 12067714)
0

Data Source:
HPRD (two hybrid)

		DLG1	WNT3A
Description		discs large MAGUK scaffold protein 1	Wnt family member 3A
Image
GO Annotations	Cellular Component	Immunological Synapse Basement Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Neuron Projection Lateral Loop Membrane Raft Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction MPP7-DLG1-LIN7 Complex Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Early Endosome Membrane Synapse Extracellular Exosome Presynapse Glutamatergic Synapse Wnt-Frizzled-LRP5/6 Complex
	Molecular Function	GMP Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Kinase Binding Protein Kinase Binding Phosphatase Binding Ionotropic Glutamate Receptor Binding Transmembrane Transporter Binding Cadherin Binding Molecular Adaptor Activity L27 Domain Binding Structural Constituent Of Postsynaptic Density	Transcription Coactivator Activity Signaling Receptor Binding Frizzled Binding Cytokine Activity Protein Binding Protein Domain Specific Binding Co-receptor Binding Identical Protein Binding Receptor Ligand Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Chemical Synaptic Transmission Nervous System Development Intracellular Protein Localization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Actin Filament Polymerization Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Astral Microtubule Organization Protein-containing Complex Localization Membrane Raft Organization Regulation Of Myelination Regulation Of Protein Localization Protein Localization To Synapse T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cortical Microtubule Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Reproductive Structure Development Embryonic Skeletal System Morphogenesis Tissue Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Establishment Of Centrosome Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hard Palate Development Negative Regulation Of ERK1 And ERK2 Cascade Bicellular Tight Junction Assembly Protein Localization To Membrane Protein Localization To Plasma Membrane Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Maintenance Of Postsynaptic Density Structure Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Sodium Ion Transmembrane Transport Regulation Of Protein Localization To Synapse Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Import Negative Regulation Of P38MAPK Cascade Regulation Of Potassium Ion Export Across Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Osteoblast Differentiation In Utero Embryonic Development Somitogenesis Positive Regulation Of Cytokine Production Heart Looping Positive Regulation Of Receptor Internalization Transcription By RNA Polymerase II Determination Of Left/right Symmetry Axonogenesis Axon Guidance Mesoderm Development Heart Development Intracellular Protein Localization Positive Regulation Of Cell Population Proliferation Anterior/posterior Pattern Specification COP9 Signalosome Assembly Regulation Of Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Neuron Projection Development Wnt Signaling Pathway Spinal Cord Association Neuron Differentiation Hippocampus Development Cell Proliferation In Forebrain Wnt Signaling Pathway Involved In Forebrain Neuroblast Division Dorsal/ventral Neural Tube Patterning Neurogenesis Hemopoiesis Platelet Activation Neuron Differentiation Extracellular Matrix Organization Mammary Gland Development Positive Regulation Of B Cell Proliferation Midbrain Development Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Skeletal Muscle Cell Differentiation Post-anal Tail Morphogenesis Synaptic Vesicle Recycling B Cell Proliferation Inner Ear Morphogenesis Cell Fate Commitment Fat Cell Differentiation Myoblast Differentiation Regulation Of Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Somatic Stem Cell Division Positive Regulation Of Mesodermal Cell Fate Specification Paraxial Mesodermal Cell Fate Commitment Animal Organ Development Positive Regulation Of Skeletal Muscle Tissue Development Positive Regulation Of Collateral Sprouting In Absence Of Injury Negative Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Neurogenesis Regulation Of Axonogenesis Modulation Of Chemical Synaptic Transmission Regulation Of Synapse Organization Canonical Wnt Signaling Pathway Cardiac Muscle Cell Fate Commitment Positive Regulation Of Dermatome Development Secondary Palate Development Regulation Of Microtubule Cytoskeleton Organization Platelet Aggregation Cellular Response To Retinoic Acid Axis Elongation Involved In Somitogenesis Positive Regulation Of Canonical Wnt Signaling Pathway Calcium Ion Transmembrane Transport Via Low Voltage-gated Calcium Channel Presynapse Assembly Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation Regulation Of Postsynapse To Nucleus Signaling Pathway Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Cardiac Muscle Cell Differentiation Regulation Of RNA Biosynthetic Process
Pathways		Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	TCF dependent signaling in response to WNT TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Regulation of FZD by ubiquitination Signaling by RNF43 mutants Formation of paraxial mesoderm Formation of the posterior neural plate Specification of the neural plate border Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs
Diseases
GWAS		Allergic rhinitis ( 25085501) Appendicular lean mass ( 33097823) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) PR interval ( 32439900) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Alcohol-related hepatocellular carcinoma ( 34902334) Birth weight ( 31043758) Diastolic blood pressure ( 28135244) Height ( 31562340) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		81 interacting genes: ACTA1 ACTN2 ACVR2B ADAM17 ADGRA2 ADGRA3 ADGRB1 ADRB1 AKAP5 APC ARHGEF26 ATP2B2 ATP2B4 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRHR1 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 DSCAM EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GRIA1 GRIK2 GRIN1 GRIN2A GRIN2B GUCY1A2 HTR2A KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PAX6 PBK PRKN PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TIAM1 TJAP1 UBASH3A UBE3A WAS WNT3A	11 interacting genes: DLG1 DLG2 DLG4 FZD1 GPC3 LRP1 LRP6 PORCN RYK WNT1 WNT2
Entrez ID		1739	89780
HPRD ID		03007	05897
Ensembl ID		ENSG00000075711	ENSG00000154342
Uniprot IDs		A0A0C4DFT3 A0A590UJ08 A0A590UJ68 A0A590UJD9 A0A590UJX2 A0A590UK48 A0A590UKA8 B4DF78 Q12959	P56704
PDB IDs		1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69 7PC3 8CN1 8CN3	7DRT 7URD 7URE 8TZR
Enriched GO Terms of Interacting Partners?		Synapse Glutamatergic Synapse Plasma Membrane Modulation Of Chemical Synaptic Transmission Postsynaptic Density Metal Ion Transport PDZ Domain Binding Regulation Of Membrane Potential Monoatomic Ion Channel Complex Postsynaptic Density Membrane Monoatomic Cation Transport Monoatomic Ion Transport Regulation Of Monoatomic Ion Transport Dendritic Spine Dendrite Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Voltage-gated Potassium Channel Complex System Process Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Inorganic Ion Transmembrane Transport Regulation Of Synaptic Plasticity Regulation Of System Process Regulation Of Transport Regulation Of Signaling Regulation Of Cell Communication Transmembrane Transport Cell Projection Monoatomic Ion Channel Activity Neuron Projection Postsynaptic Membrane Nervous System Process Positive Regulation Of Synaptic Transmission Action Potential Regulation Of Multicellular Organismal Process Potassium Ion Transmembrane Transport Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Potassium Ion Transport Membrane Trans-synaptic Signaling Synaptic Signaling Regulation Of Postsynaptic Membrane Potential Cell-cell Junction Modulation Of Excitatory Postsynaptic Potential Signal Transduction Axon Signaling	Midbrain Dopaminergic Neuron Differentiation Canonical Wnt Signaling Pathway Frizzled Binding Dopaminergic Neuron Differentiation Wnt Signaling Pathway Wnt-protein Binding Central Nervous System Neuron Differentiation Cell-cell Signaling Signaling Cell Communication Wnt Signalosome Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Wnt Receptor Activity Cell Surface Receptor Signaling Pathway Anatomical Structure Morphogenesis Postsynaptic Density Membrane Ionotropic Glutamate Receptor Binding Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Cellular Component Organization Neuron Differentiation Branching Involved In Ureteric Bud Morphogenesis Glial Cell-neuron Signaling Tissue Morphogenesis Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Non-canonical Wnt Signaling Pathway Cell Proliferation In Midbrain Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Synapse Signal Transduction Hard Palate Development GMP Kinase Activity Endocytic Vesicle Membrane Neuromuscular Junction Protein Localization To Cell Junction GDP Metabolic Process Juxtaparanode Region Of Axon Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Tube Morphogenesis Protein Localization To Membrane Chemical Synaptic Transmission Kinase Binding Cellular Response To Potassium Ion Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Low-density Lipoprotein Particle Receptor Activity Developmental Process Trans-synaptic Signaling Regulation Of BMP Signaling Pathway Neurogenesis
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