DLG1 and GRIK2

Number of citations: 0 (PubMedID 9808460)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		DLG1	GRIK2
Name		discs large MAGUK scaffold protein 1	glutamate ionotropic receptor kainate type subunit 2
Structure
GO Annotations	Cellular Component	Immunological Synapse Basement Membrane Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Neuron Projection Lateral Loop Membrane Raft Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Anchoring Junction MPP7-DLG1-LIN7 Complex Synaptic Membrane Postsynaptic Density Membrane Glutamatergic Synapse	Plasma Membrane Ionotropic Glutamate Receptor Complex Postsynaptic Density Membrane Axon Dendrite Dendrite Cytoplasm Kainate Selective Glutamate Receptor Complex Presynaptic Membrane Neuronal Cell Body Terminal Bouton Perikaryon Synapse Postsynaptic Membrane Mossy Fiber Rosette Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	GMP Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Kinase Binding Protein Kinase Binding Phosphatase Binding Ionotropic Glutamate Receptor Binding Transmembrane Transporter Binding Cadherin Binding Molecular Adaptor Activity L27 Domain Binding Structural Constituent Of Postsynaptic Density	SNARE Binding Glutamate-gated Receptor Activity Monoatomic Ion Channel Activity Extracellularly Glutamate-gated Ion Channel Activity Glutamate Receptor Activity Ligand-gated Monoatomic Ion Channel Activity Kainate Selective Glutamate Receptor Activity Glutamate-gated Calcium Ion Channel Activity PDZ Domain Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity Identical Protein Binding Scaffold Protein Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Chemical Synaptic Transmission Nervous System Development Intracellular Protein Localization Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Actin Filament Polymerization Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Astral Microtubule Organization Protein-containing Complex Localization Membrane Raft Organization Regulation Of Myelination Regulation Of Protein Localization Protein Localization To Synapse T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Regulation Of Potassium Ion Transport Positive Regulation Of Potassium Ion Transport Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cortical Microtubule Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity GMP Metabolic Process GDP Metabolic Process Reproductive Structure Development Embryonic Skeletal System Morphogenesis Tissue Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Establishment Of Centrosome Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Hard Palate Development Negative Regulation Of ERK1 And ERK2 Cascade Bicellular Tight Junction Assembly Protein Localization To Membrane Protein Localization To Plasma Membrane Receptor Localization To Synapse Cell-cell Adhesion Regulation Of Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Maintenance Of Postsynaptic Density Structure Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Sodium Ion Transmembrane Transport Regulation Of Protein Localization To Synapse Positive Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Import Negative Regulation Of P38MAPK Cascade Regulation Of Potassium Ion Export Across Plasma Membrane Protein Localization To Cell Periphery Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Behavioral Fear Response Monoatomic Ion Transport Intracellular Calcium Ion Homeostasis Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Neuronal Action Potential Calcium-mediated Signaling Monoatomic Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Membrane Potential Receptor Clustering Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of JNK Cascade Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Short-term Neuronal Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Positive Regulation Of Synaptic Transmission Neuron Apoptotic Process Negative Regulation Of Synaptic Transmission, Glutamatergic Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Modulation Of Excitatory Postsynaptic Potential Presynaptic Modulation Of Chemical Synaptic Transmission Regulation Of Presynaptic Membrane Potential Detection Of Cold Stimulus Involved In Thermoception
Pathways		Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor NrCAM interactions Activation of Ca-permeable Kainate Receptor RAF/MAP kinase cascade Synaptic adhesion-like molecules Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation	Activation of Na-permeable kainate receptors Activation of Ca-permeable Kainate Receptor
Drugs		None	Glutamic acid Butabarbital Butalbital Topiramate Talbutal Pentobarbital Secobarbital Metharbital Thiopental Primidone Methylphenobarbital Phenobarbital Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Domoic Acid Quisqualic acid 2s,4r-4-Methylglutamate
Diseases		None	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Allergic rhinitis ( 25085501 ) Appendicular lean mass ( 33097823 ) Diastolic blood pressure ( 30224653 ) Heel bone mineral density ( 30598549 ) Metabolite levels ( 23823483 ) PR interval ( 32439900 ) Waist circumference adjusted for body mass index ( 34021172 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	A body shape index ( 34021172 ) Age-related cognitive decline (language) (slope of z-scores) ( 30954325 ) Biochemical measures ( 19260141 ) Cardiac hypertrophy ( 21348951 ) Cerebral amyloid angiopathy x APOEe4 status interaction in Alzheimer’s disease ( 34020725 ) Emphysema imaging phenotypes ( 26030696 ) Heart rate response to recovery post exercise (20 sec) ( 29497042 ) Longevity (90 years and older) ( 25199915 ) Obesity-related traits ( 23251661 ) Obsessive-compulsive disorder ( 22889921 ) Palmitic acid (16:0) levels ( 23362303 ) Pursuit maintenance gain ( 29064472 ) Renal function-related traits (eGRFcrea) ( 22797727 ) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429 ) Waist circumference adjusted for body mass index ( 34021172 ) Weight ( 28552196 )
Interacting Genes		81 interacting genes: ACTA1 ACTN2 ACVR2B ADAM17 ADGRA2 ADGRA3 ADGRB1 ADRB1 AKAP5 APC ARHGEF26 ATP2B2 ATP2B4 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRHR1 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 DSCAM EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GRIA1 GRIK2 GRIN1 GRIN2A GRIN2B GUCY1A2 HTR2A KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PAX6 PBK PRKN PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TIAM1 TJAP1 UBASH3A UBE3A WAS WNT3A	20 interacting genes: CALCOCO1 CASK CDH2 CTNNB1 CTNND1 DLG1 DLG3 DLG4 GRIA1 GRID2 GRIK1 GRIK4 GRIK5 GRIP1 LIN7B NETO1 PICK1 PRKAA1 SDCBP TRIM25
Entrez ID		1739	2898
HPRD ID		03007	00692
Ensembl ID		ENSG00000075711	ENSG00000164418
Uniprot IDs		A0A0C4DFT3 A0A590UJ08 A0A590UJ68 A0A590UJD9 A0A590UJX2 A0A590UK48 A0A590UKA8 B4DF78 Q12959	A0A8D9PH75 A8K0H7 Q13002 Q8IY40
PDB IDs		1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69 7PC3 8CN1 8CN3	3QXM 5CMM
GO Terms Enriched among Interactors		Synapse Glutamatergic Synapse Plasma Membrane Modulation Of Chemical Synaptic Transmission Postsynaptic Density Metal Ion Transport PDZ Domain Binding Regulation Of Membrane Potential Monoatomic Ion Channel Complex Postsynaptic Density Membrane Monoatomic Cation Transport Monoatomic Ion Transport Regulation Of Monoatomic Ion Transport Dendritic Spine Dendrite Monoatomic Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Voltage-gated Potassium Channel Complex System Process Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Biological Quality Inorganic Ion Transmembrane Transport Regulation Of Synaptic Plasticity Regulation Of System Process Regulation Of Transport Regulation Of Signaling Regulation Of Cell Communication Transmembrane Transport Cell Projection Monoatomic Ion Channel Activity Neuron Projection Postsynaptic Membrane Nervous System Process Positive Regulation Of Synaptic Transmission Action Potential Regulation Of Multicellular Organismal Process Potassium Ion Transmembrane Transport Chemical Synaptic Transmission Glutamate-gated Calcium Ion Channel Activity Potassium Ion Transport Membrane Trans-synaptic Signaling Synaptic Signaling Regulation Of Postsynaptic Membrane Potential Cell-cell Junction Modulation Of Excitatory Postsynaptic Potential Signal Transduction Axon Signaling	Postsynaptic Density Membrane Synapse Postsynaptic Membrane Chemical Synaptic Transmission Ionotropic Glutamate Receptor Signaling Pathway Trans-synaptic Signaling Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Synaptic Signaling Ligand-gated Ion Channel Signaling Pathway Glutamate Receptor Signaling Pathway Cell-cell Junction Presynaptic Membrane Ligand-gated Monoatomic Ion Channel Activity Cell-cell Signaling Signaling Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Cell Communication Adherens Junction Synaptic Transmission, Glutamatergic Modulation Of Chemical Synaptic Transmission Receptor Localization To Synapse Receptor Clustering Protein Localization To Synapse Kainate Selective Glutamate Receptor Complex Kainate Selective Glutamate Receptor Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Membrane Potential AMPA Glutamate Receptor Complex Protein Localization To Membrane Ionotropic Glutamate Receptor Binding Protein Localization To Cell Junction Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Plasma Membrane Localization Within Membrane Neuron Projection Intracellular Protein Localization Regulation Of Postsynaptic Membrane Potential Glutamate-gated Receptor Activity Basolateral Plasma Membrane Regulation Of Transport Postsynaptic Density Phosphatase Binding Regulation Of Biological Quality Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Cell-cell Adhesion Protein-containing Complex Localization Monoatomic Ion Channel Activity Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane