SLC25A6 and AP2B1

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		SLC25A6	AP2B1
Gene Name		solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	adaptor-related protein complex 2, beta 1 subunit
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Inner Membrane Presequence Translocase Complex Integral Component Of Membrane	Cytosol Plasma Membrane Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	ATP:ADP Antiporter Activity Protein Binding	Signal Sequence Binding Protein Binding Protein Transporter Activity Clathrin Binding Clathrin Adaptor Activity
	Biological Process	Energy Reserve Metabolic Process Protein Targeting To Mitochondrion Apoptotic Process ADP Transport ATP Transport Viral Process Modulation By Virus Of Host Morphology Or Physiology Viral Life Cycle Cellular Protein Metabolic Process Small Molecule Metabolic Process Active Induction Of Host Immune Response By Virus Regulation Of Insulin Secretion Transmembrane Transport	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis
Pathways		Integration of energy metabolism Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization HIV Infection Regulation of insulin secretion Host Interactions of HIV factors Mitochondrial protein import Host Interactions with Influenza Factors Influenza Infection Influenza Virus Induced Apoptosis Interactions of Vpr with host cellular proteins	Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs		Clodronate
Diseases
GWAS			Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		18 interactors: AP2B1 CHGB FGFR3 KARS KRT31 KRTAP4-12 LZTS2 MID2 MTUS2 NOTCH2NL PLSCR1 PRSS23 STRN4 TEKT4 TRAF1 TRIM23 TRIP6 VIM	44 interactors: ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARRB1 ATM ATP6V1G1 BUB1 BUB1B CLINT1 CLTC DHX58 FAM46C GTF2I HIP1 ITSN1 KIAA0408 KPNA2 LDLRAP1 MEA1 MLH1 NECAP2 NEU4 NUP54 PIP5K1C POM121 RAPGEF3 RIBC2 SLC25A6 SMAD4 SMURF1 SNAP91 TERF2IP TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 XRCC6BP1
Entrez ID		293	163
HPRD ID		02461	03015
Ensembl ID			ENSG00000006125
Uniprot IDs		P12236 Q6I9V5	K7EJT8 P63010 Q96EL6
PDB IDs			1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7
Enriched GO Terms of Interacting Partners?		Lens Fiber Cell Development Lens Fiber Cell Differentiation Viral Process Lysyl-tRNA Aminoacylation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Viral Process Diadenosine Tetraphosphate Biosynthetic Process Regulation Of Signaling Lens Development In Camera-type Eye Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Glial Cell Development Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity	Protein Localization Regulation Of Defense Response To Virus By Virus Endocytosis Viral Process Cellular Localization Protein Transport Regulation Of Defense Response To Virus Vesicle-mediated Transport Establishment Of Protein Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Establishment Of Localization In Cell Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Intracellular Transport Clathrin Coat Assembly Membrane Organization Receptor-mediated Endocytosis Cellular Protein Localization Organelle Organization Regulation Of Cellular Component Organization Mitotic Spindle Assembly Checkpoint Negative Regulation Of Chromosome Organization Post-Golgi Vesicle-mediated Transport Cellular Response To Growth Factor Stimulus Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Apoptotic Process Clathrin-mediated Endocytosis Response To Growth Factor Negative Regulation Of Chromosome Segregation Programmed Cell Death Cell Cycle Process Cell Differentiation Regulation Of Mitotic Sister Chromatid Separation Cell Development Cell Death Death Regulation Of Signaling Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Chromosome Organization Regulation Of Signal Transduction Cellular Protein Complex Assembly Pathway-restricted SMAD Protein Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Cellular Response To Organic Substance Negative Regulation Of Protein Catabolic Process Cell Activation Cell Cycle Mitotic Cell Cycle Process
Tagcloud ?		aberrant blastocyst bovine cattle clones cows embryo embryos freemartin gestation hatched hprt inner lost mecp2 pregnancies recipient reconstructed rps4x rq scnt somatic telomerase transcript transfer twin xiap xist zfx	17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Difference) ?		aberrant blastocyst bovine cattle clones cows embryo embryos freemartin gestation hatched hprt inner lost mecp2 pregnancies recipient reconstructed rps4x rq scnt somatic telomerase transcript transfer twin xiap xist zfx	17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Intersection) ?