SLC25A6 and KARS

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SLC25A6	KARS
Gene Name		solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6	lysyl-tRNA synthetase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane Mitochondrial Inner Membrane Presequence Translocase Complex Integral Component Of Membrane	Extracellular Region Nucleus Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Microtubule Cytoskeleton Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	ATP:ADP Antiporter Activity Protein Binding	TRNA Binding Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Metal Ion Binding
	Biological Process	Energy Reserve Metabolic Process Protein Targeting To Mitochondrion Apoptotic Process ADP Transport ATP Transport Viral Process Modulation By Virus Of Host Morphology Or Physiology Viral Life Cycle Cellular Protein Metabolic Process Small Molecule Metabolic Process Active Induction Of Host Immune Response By Virus Regulation Of Insulin Secretion Transmembrane Transport	TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Gene Expression Diadenosine Tetraphosphate Biosynthetic Process Viral Process
Pathways		Integration of energy metabolism Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization HIV Infection Regulation of insulin secretion Host Interactions of HIV factors Mitochondrial protein import Host Interactions with Influenza Factors Influenza Infection Influenza Virus Induced Apoptosis Interactions of Vpr with host cellular proteins	Cytosolic tRNA aminoacylation tRNA Aminoacylation Mitochondrial tRNA aminoacylation
Drugs		Clodronate	L-Lysine
Diseases
GWAS
Protein-Protein Interactions		18 interactors: AP2B1 CHGB FGFR3 KARS KRT31 KRTAP4-12 LZTS2 MID2 MTUS2 NOTCH2NL PLSCR1 PRSS23 STRN4 TEKT4 TRAF1 TRIM23 TRIP6 VIM	15 interactors: AIMP2 DARS2 EEF1D EEF1G FRS3 GAPDH GEMIN4 MAPK1 MAPK14 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 VIM
Entrez ID		293	3735
HPRD ID		02461	03249
Ensembl ID			ENSG00000065427
Uniprot IDs		P12236 Q6I9V5	Q15046
PDB IDs			3BJU 4DPG
Enriched GO Terms of Interacting Partners?		Lens Fiber Cell Development Lens Fiber Cell Differentiation Viral Process Lysyl-tRNA Aminoacylation Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Viral Process Diadenosine Tetraphosphate Biosynthetic Process Regulation Of Signaling Lens Development In Camera-type Eye Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity Glial Cell Development Apoptotic Process Positive Regulation Of NF-kappaB Transcription Factor Activity	Apoptotic Process Retrograde Axon Cargo Transport Programmed Cell Death Cell Death Death Small Molecule Metabolic Process Translation Activation Of MAPK Activity Biosynthetic Process Translational Elongation Enzyme Linked Receptor Protein Signaling Pathway NcRNA Metabolic Process Platelet Activation Organelle Organization Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of MAP Kinase Activity Viral Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Osteoclast Differentiation Cellular Protein Metabolic Process Gliogenesis Gene Expression Axon Cargo Transport Regulation Of MAPK Cascade Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Transmission Of Nerve Impulse Cellular Metabolic Process Cellular Response To Organic Substance Activation Of Protein Kinase Activity Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Mitochondrial Asparaginyl-tRNA Aminoacylation Response To Antipsychotic Drug Peptidyl-cysteine S-trans-nitrosylation P38MAPK Cascade TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Response To Other Organism Toll-like Receptor 3 Signaling Pathway Regulation Of Phosphorylation MyD88-dependent Toll-like Receptor Signaling Pathway Cell Aging
Tagcloud ?		aberrant blastocyst bovine cattle clones cows embryo embryos freemartin gestation hatched hprt inner lost mecp2 pregnancies recipient reconstructed rps4x rq scnt somatic telomerase transcript transfer twin xiap xist zfx	aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical
Tagcloud (Difference) ?		aberrant blastocyst bovine cattle clones cows embryo embryos freemartin gestation hatched hprt inner lost mecp2 pregnancies recipient reconstructed rps4x rq scnt somatic telomerase transcript transfer twin xiap xist zfx	aars acylating aminoacyl aminoars aminoarss bodies canonical dorsal drg functions ganglia glutaminyl horn injured lysyl nerve pharmaceutical possibility powerful primers qars root satellite sensory spinal synthetase synthetases trna typical
Tagcloud (Intersection) ?