ELP2 and STAT5B

Number of citations of the paper that reports this interaction (PMID 10954736)
18

Data Source:
HPRD (in vitro, two hybrid)

		ELP2	STAT5B
Gene Name		elongator acetyltransferase complex subunit 2	signal transducer and activator of transcription 5B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Core Binding Protein Kinase Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Protein Phosphatase Binding Glucocorticoid Receptor Binding Protein Dimerization Activity
	Biological Process	Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Regulation Of JAK-STAT Cascade	Allantoin Metabolic Process Luteinization Response To Hypoxia Natural Killer Cell Differentiation Liver Development Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Acute-phase Response JAK-STAT Cascade Female Pregnancy Lactation Regulation Of Steroid Metabolic Process Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus T Cell Differentiation In Thymus Prolactin Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Progesterone Metabolic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Creatinine Metabolic Process Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cellular Component Movement JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Signaling by PDGF Signaling by FGFR in disease Cytokine Signaling in Immune system Signaling by ERBB4 Signaling by SCF-KIT Signaling by Interleukins Nuclear signaling by ERBB4 Downstream signal transduction Signaling by FGFR1 mutants Interleukin-7 signaling Signaling by FGFR mutants Interleukin-2 signaling Prolactin receptor signaling Signaling by FGFR1 fusion mutants Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Growth hormone receptor signaling
Drugs			Dasatinib
Diseases
GWAS			Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		7 interactors: CTDP1 IKBKAP JAK1 JAK2 STAT1 STAT3 STAT5B	49 interactors: AFTPH APP CBL CD247 CENPJ CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT MAPK1 NCOR2 NMI NR3C1 PDGFRA PDGFRB POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA SERTAD1 SHC1 SRC STAP2 STAT1 STAT3 STAT5A TEK TFG
Entrez ID		55250	6777
HPRD ID		15443	05037
Ensembl ID		ENSG00000134759	ENSG00000173757
Uniprot IDs		Q6IA86	P51692
PDB IDs
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone JAK-STAT Cascade Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Response To Cytokine Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Response To Interleukin-2 Response To Peptide Hormone Interferon-gamma-mediated Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Interferon-gamma Defense Response Cellular Response To Hormone Stimulus Response To Interferon-gamma Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cellular Component Movement Positive Regulation Of Cellular Biosynthetic Process Response To Organonitrogen Compound Tumor Necrosis Factor-mediated Signaling Pathway Response To Lipid Acute-phase Response Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-tyrosine Autophosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Regulation Of Type I Interferon-mediated Signaling Pathway Response To Lipopolysaccharide Response To Hormone Response To Molecule Of Bacterial Origin Positive Regulation Of Cellular Component Movement Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Immune System Process Response To Antibiotic Transcription Elongation From RNA Polymerase II Promoter	Cellular Response To Organic Substance Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Response To Hormone Regulation Of MAPK Cascade Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Response To Cytokine Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Phosphorylation Regulation Of Signal Transduction Growth Hormone Receptor Signaling Pathway Regulation Of Protein Phosphorylation Cellular Response To Hormone Stimulus Cellular Response To Growth Hormone Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response Signaling Regulation Of Phosphorus Metabolic Process Signal Transduction JAK-STAT Cascade Positive Regulation Of MAPK Cascade Defense Response Cell Communication Regulation Of Signaling Cellular Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Immune System Process Cellular Response To Cytokine Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Organ Development Cellular Response To Peptide Response To Growth Hormone Positive Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Protein Metabolic Process Response To Peptide Hormone Positive Regulation Of Transferase Activity Innate Immune Response
Tagcloud ?		accomplished biocompatibility c5 conduit dodecyl elastin elongated elp1 elp3 elps endowed fabrication glutamic glutaraledhyde immunofluorostaining isoleucine itc penta pentapeptide redv s100 schwann vpavg vpgeg vpgig vpgkg vpgvg wst	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stats yeast
Tagcloud (Difference) ?		accomplished biocompatibility c5 conduit dodecyl elastin elongated elp1 elp3 elps endowed fabrication glutamic glutaraledhyde immunofluorostaining isoleucine itc penta pentapeptide redv s100 schwann vpavg vpgeg vpgig vpgkg vpgvg wst	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stats yeast
Tagcloud (Intersection) ?