ELP2 and STAT5B

Number of citations of the paper that reports this interaction (PubMedID 10954736)
45

Data Source:
HPRD (two hybrid, in vitro)

		ELP2	STAT5B
Description		elongator acetyltransferase complex subunit 2	signal transducer and activator of transcription 5B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Elongation Factor Complex Elongator Holoenzyme Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	RNA Polymerase II Complex Binding Protein Kinase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Nuclear Glucocorticoid Receptor Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity
	Biological Process	TRNA Wobble Uridine Modification Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Regulation Of Translation TRNA Processing Regulation Of Receptor Signaling Pathway Via JAK-STAT	Mitotic Cell Cycle Luteinization Natural Killer Cell Differentiation Natural Killer Cell Proliferation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Sex Differentiation Female Pregnancy Lactation Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Regulation Of Steroid Metabolic Process Cytokine-mediated Signaling Pathway Taurine Metabolic Process Lipid Storage Lymphocyte Differentiation Regulation Of Cell Adhesion B Cell Differentiation Erythrocyte Differentiation Regulation Of Epithelial Cell Differentiation Response To Estradiol Positive Regulation Of Interleukin-2 Production Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process T Cell Differentiation In Thymus Erythropoietin-mediated Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Regulation Of Cell Population Proliferation Natural Killer Cell Mediated Cytotoxicity Progesterone Metabolic Process Gamma-delta T Cell Differentiation T Cell Homeostasis Response To Peptide Hormone Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Inflammatory Response Activated T Cell Proliferation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus Mast Cell Migration Regulation Of Hemopoiesis
Pathways		HATs acetylate histones	Prolactin receptor signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Signaling by Leptin Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-20 family signaling Interleukin-15 signaling Interleukin-9 signaling Interleukin-2 signaling Interleukin-2 signaling Interleukin-21 signaling Erythropoietin activates STAT5 STAT5 Activation Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by CSF3 (G-CSF) STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins Inactivation of CSF3 (G-CSF) signaling Growth hormone receptor signaling Growth hormone receptor signaling
Drugs			Dasatinib
Diseases			Growth hormone insensitivity with immunodeficiency
GWAS		Serum metabolite levels ( 33031748)	A body shape index ( 34021172) Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 32296059 34103634 31361310) Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233 27569725) Lymphocyte count ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494) Paracentral lobule volume ( 31530798) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		8 interacting genes: CTDP1 ELP1 ELP6 JAK1 JAK2 STAT1 STAT3 STAT5B	63 interacting genes: AFTPH APP CBL CBR1 CD247 CDKN1A CHAF1A CPAP CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 HNRNPA2B1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT LGALS14 LMO4 MAPK1 MED25 NCOR2 NMI NR3C1 PDGFRA PDGFRB PIK3R3 POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA RBBP4 SERTAD1 SHC1 SRC STAC STAP2 STAT1 STAT3 STAT5A SUOX TEK TFG TSSK3 USP2 WEE2-AS1
Entrez ID		55250	6777
HPRD ID		15443	05037
Ensembl ID		ENSG00000134759	ENSG00000173757
Uniprot IDs		Q6IA86	P51692
PDB IDs		8PTX 8PTY 8PTZ 8PU0	6MBW 6MBZ
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Type II Interferon-mediated Signaling Pathway Interleukin-6-mediated Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Erythrocyte Differentiation Response To Cytokine Response To Peptide Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Elongator Holoenzyme Complex Interferon-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway RNA Metabolic Process Erythropoietin-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Cellular Response To Hormone Stimulus Interleukin-2-mediated Signaling Pathway Regulation Of Defense Response Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Myeloid Cell Differentiation T-helper 17 Cell Lineage Commitment Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Natural Killer Cell Proliferation Nuclear Glucocorticoid Receptor Binding Regulation Of Skeletal Muscle Cell Proliferation TRNA Wobble Uridine Modification Cellular Response To Cytokine Stimulus RNA Polymerase II Transcription Regulator Complex T-helper Cell Lineage Commitment Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Homotypic Cell-cell Adhesion Photoreceptor Cell Differentiation Regulation Of Macromolecule Biosynthetic Process CD4-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Primary Metabolic Process Alpha-beta T Cell Lineage Commitment Positive Regulation Of Cytokine Production	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cytokine-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell Population Proliferation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Receptor Signaling Pathway Via JAK-STAT Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Developmental Process Positive Regulation Of Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Population Proliferation Regulation Of Phosphorus Metabolic Process Regulation Of MAPK Cascade Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Signal Transduction Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of MAPK Cascade Phosphotyrosine Residue Binding Response To Growth Factor Animal Organ Development Regulation Of Intracellular Signal Transduction Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Migration Cell Surface Receptor Signaling Pathway Via STAT Peptidyl-tyrosine Phosphorylation Regulation Of Locomotion Regulation Of Immune System Process Regulation Of Signal Transduction Regulation Of Cell Migration Positive Regulation Of Metabolic Process Positive Regulation Of Cell Motility Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Locomotion Regulation Of Multicellular Organismal Process Protein Tyrosine Kinase Activity Regulation Of Cell Adhesion Regulation Of Cell Motility Regulation Of Cell Differentiation Phosphorylation Regulation Of Immune Response Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Activation Positive Regulation Of Phosphate Metabolic Process Regulation Of Signaling Regulation Of Cell Communication
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