ELP2 and IKBKAP

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (pull down, biochemical, affinity chromatography technology)

		ELP2	IKBKAP
Gene Name		elongator acetyltransferase complex subunit 2	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex	Histone Acetyltransferase Complex Nucleolus Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex
	Molecular Function	RNA Polymerase II Core Binding Protein Kinase Binding	RNA Polymerase II Core Binding Signal Transducer Activity Protein Binding Phosphorylase Kinase Regulator Activity
	Biological Process	Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Regulation Of JAK-STAT Cascade	Chromatin Organization Regulation Of Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Protein Complex Assembly Protein Phosphorylation Immune Response Signal Transduction Positive Regulation Of Cell Migration Regulation Of Protein Kinase Activity
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Chromatin modifying enzymes Chromatin organization HATs acetylate histones
Drugs
Diseases
GWAS
Protein-Protein Interactions		7 interactors: CTDP1 IKBKAP JAK1 JAK2 STAT1 STAT3 STAT5B	26 interactors: BAG6 BARD1 CCT5 CDKN2B CHUK CSTF2 ELP2 ELP3 HTT IKBKB IRF4 MAN2A2 MAP3K14 MAP3K7 MAPK8 MRPL42 NDUFB9 NFKBIA NIPSNAP3A PBX2 PLP2 SDHAF2 SNAPIN TAC3 TTR TXNDC9
Entrez ID		55250	8518
HPRD ID		15443	04763
Ensembl ID		ENSG00000134759	ENSG00000070061
Uniprot IDs		Q6IA86	O95163 Q8N516
PDB IDs
Enriched GO Terms of Interacting Partners?		JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Growth Hormone JAK-STAT Cascade Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Innate Immune Response Response To Cytokine Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Transcription From RNA Polymerase II Promoter Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Response To Interleukin-2 Response To Peptide Hormone Interferon-gamma-mediated Signaling Pathway Cellular Response To Organonitrogen Compound Response To Peptide Cellular Response To Interferon-gamma Defense Response Cellular Response To Hormone Stimulus Response To Interferon-gamma Regulation Of Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Cellular Component Movement Positive Regulation Of Cellular Biosynthetic Process Response To Organonitrogen Compound Tumor Necrosis Factor-mediated Signaling Pathway Response To Lipid Acute-phase Response Regulation Of Transcription From RNA Polymerase II Promoter Peptidyl-tyrosine Autophosphorylation Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Immune Response Regulation Of Type I Interferon-mediated Signaling Pathway Response To Lipopolysaccharide Response To Hormone Response To Molecule Of Bacterial Origin Positive Regulation Of Cellular Component Movement Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Smooth Muscle Cell Proliferation Immune System Process Response To Antibiotic Transcription Elongation From RNA Polymerase II Promoter	Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Toll-like Receptor 4 Signaling Pathway Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To External Stimulus Positive Regulation Of Innate Immune Response Fc-epsilon Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Innate Immune Response T Cell Receptor Signaling Pathway Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Fc Receptor Signaling Pathway Internal Protein Amino Acid Acetylation Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Acetylation Antigen Receptor-mediated Signaling Pathway Histone H3 Acetylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Growth Factor Stimulus Response To Growth Factor Negative Regulation Of Apoptotic Process Positive Regulation Of Cytokine Production Negative Regulation Of Programmed Cell Death Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Peptidyl-amino Acid Modification Regulation Of Signal Transduction Negative Regulation Of Cell Death Intracellular Receptor Signaling Pathway Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Response To Other Organism Positive Regulation Of Type I Interferon Production
Tagcloud ?		accomplished biocompatibility c5 conduit dodecyl elastin elongated elp1 elp3 elps endowed fabrication glutamic glutaraledhyde immunofluorostaining isoleucine itc penta pentapeptide redv s100 schwann vpavg vpgeg vpgig vpgkg vpgvg wst	advance autonomously autosomal awaited believed compensate deficiencies devastating dysautonomia faithfully fd hallmark ikap implicating myelin myelination neurodevelopmental oli oligodendrocyte postmortem proof reason recapitulate recessive scarcity severely skipping splice underscoring
Tagcloud (Difference) ?		accomplished biocompatibility c5 conduit dodecyl elastin elongated elp1 elp3 elps endowed fabrication glutamic glutaraledhyde immunofluorostaining isoleucine itc penta pentapeptide redv s100 schwann vpavg vpgeg vpgig vpgkg vpgvg wst	advance autonomously autosomal awaited believed compensate deficiencies devastating dysautonomia faithfully fd hallmark ikap implicating myelin myelination neurodevelopmental oli oligodendrocyte postmortem proof reason recapitulate recessive scarcity severely skipping splice underscoring
Tagcloud (Intersection) ?