ELP2 and ELP6

Number of citations of the paper that reports this interaction (PubMedID 36617428)
102

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ELP2	ELP6
Description		elongator acetyltransferase complex subunit 2	elongator acetyltransferase complex subunit 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Transcription Elongation Factor Complex Elongator Holoenzyme Complex	Nucleus Cytoplasm Cytosol Elongator Holoenzyme Complex
	Molecular Function	RNA Polymerase II Complex Binding Protein Kinase Binding	Protein Binding
	Biological Process	TRNA Wobble Uridine Modification Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Regulation Of Translation TRNA Processing Regulation Of Receptor Signaling Pathway Via JAK-STAT	TRNA Wobble Uridine Modification Translation Regulation Of Translation Protein Folding Autophagy Apoptotic Process Response To Unfolded Protein Locomotory Behavior TRNA Processing Ubiquitin Recycling Positive Regulation Of Cell Migration Cellular Response To Stress Photoreceptor Cell Differentiation Homeostasis Of Number Of Retina Cells Neuromuscular Process Controlling Balance Neuromuscular Process Neuron Apoptotic Process Retina Development In Camera-type Eye Motor Behavior Autophagosome Maturation Inflammasome-mediated Signaling Pathway
Pathways		HATs acetylate histones	HATs acetylate histones
Drugs
Diseases
GWAS		Serum metabolite levels ( 33031748)	Refractive error ( 32231278)
Interacting Genes		8 interacting genes: CTDP1 ELP1 ELP6 JAK1 JAK2 STAT1 STAT3 STAT5B	7 interacting genes: CLK1 ELP1 ELP2 ELP3 ELP4 MLH1 SRPK2
Entrez ID		55250	54859
HPRD ID		15443	07884
Ensembl ID		ENSG00000134759	ENSG00000163832
Uniprot IDs		Q6IA86	C9IYN7 Q0PNE2
PDB IDs		8PTX 8PTY 8PTZ 8PU0
Enriched GO Terms of Interacting Partners?		Growth Hormone Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Growth Hormone Receptor Signaling Pathway Interleukin-9-mediated Signaling Pathway CCR5 Chemokine Receptor Binding Type II Interferon-mediated Signaling Pathway Interleukin-6-mediated Signaling Pathway Positive Regulation Of Growth Factor Dependent Skeletal Muscle Satellite Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Erythrocyte Differentiation Positive Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Erythrocyte Differentiation Response To Cytokine Response To Peptide Negative Regulation Of 3'-UTR-mediated MRNA Stabilization Interleukin-23-mediated Signaling Pathway Elongator Holoenzyme Complex Interferon-mediated Signaling Pathway Interleukin-11-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway RNA Metabolic Process Erythropoietin-mediated Signaling Pathway Growth Hormone Receptor Binding Interleukin-10-mediated Signaling Pathway Interleukin-15-mediated Signaling Pathway Cellular Response To Hormone Stimulus Interleukin-2-mediated Signaling Pathway Regulation Of Defense Response Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Myeloid Cell Differentiation T-helper 17 Cell Lineage Commitment Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Regulation Of Skeletal Muscle Satellite Cell Proliferation Regulation Of Natural Killer Cell Proliferation Nuclear Glucocorticoid Receptor Binding Regulation Of Skeletal Muscle Cell Proliferation TRNA Wobble Uridine Modification Cellular Response To Cytokine Stimulus RNA Polymerase II Transcription Regulator Complex T-helper Cell Lineage Commitment Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Homotypic Cell-cell Adhesion Photoreceptor Cell Differentiation Regulation Of Macromolecule Biosynthetic Process CD4-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Primary Metabolic Process Alpha-beta T Cell Lineage Commitment Positive Regulation Of Cytokine Production	Elongator Holoenzyme Complex TRNA Wobble Uridine Modification TRNA Modification TRNA Processing RNA Modification TRNA Wobble Base 5-methoxycarbonylmethyl-2-thiouridinylation Phosphorylase Kinase Regulator Activity TRNA Metabolic Process RNA Metabolic Process RNA Processing Regulation Of Translation Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Transcription Elongation Factor Complex Regulation Of Primary Metabolic Process Nucleic Acid Metabolic Process Post-transcriptional Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleus Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment TRNA Uridine(34) Acetyltransferase Activity TRNA Binding Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Male Meiosis Chromosome Segregation MutLalpha Complex Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Nuclear Speck Organization Regulation Of Nucleobase-containing Compound Metabolic Process Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Positive Regulation Of Isotype Switching To IgA Isotypes Intrinsic Apoptotic Signaling Pathway Regulation Of RNA Splicing MutSalpha Complex Binding Regulation Of Mitotic Recombination Regulation Of Protein Metabolic Process Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization R-loop Processing Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes PERK-mediated Unfolded Protein Response
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