CSF2RB and HCK

Number of citations of the paper that reports this interaction (PubMedID 9195918)
0

Data Source:
HPRD (in vitro, in vivo)

		CSF2RB	HCK
Description		colony stimulating factor 2 receptor subunit beta	HCK proto-oncogene, Src family tyrosine kinase
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex	Nucleus Cytoplasm Lysosome Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Caveola Focal Adhesion Cytoplasmic Side Of Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Cell Projection Membrane Raft Anchoring Junction
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity	Nucleotide Binding Phosphotyrosine Residue Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding Lipid Binding Kinase Activity Transferase Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Respiratory Gaseous Exchange By Respiratory System Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Leukocyte Proliferation	Immune System Process Leukocyte Migration Involved In Immune Response Innate Immune Response-activating Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Exocytosis Phagocytosis Response To Stress Inflammatory Response Cell Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Integrin-mediated Signaling Pathway Mesoderm Development Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Cell Differentiation Positive Regulation Of Actin Filament Polymerization Lipopolysaccharide-mediated Signaling Pathway Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Apoptotic Process Leukocyte Degranulation Innate Immune Response Respiratory Burst After Phagocytosis Protein Autophosphorylation Regulation Of Inflammatory Response Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Leukocyte Migration Regulation Of DNA-binding Transcription Factor Activity Type II Interferon-mediated Signaling Pathway Cellular Response To Lipid Regulation Of Podosome Assembly
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling	Nef and signal transduction FCGR activation Regulation of signaling by CBL Regulation of signaling by CBL FCGR3A-mediated IL10 synthesis FCGR3A-mediated phagocytosis Signaling by CSF3 (G-CSF) Signaling by CSF3 (G-CSF) Signaling by CSF1 (M-CSF) in myeloid cells Inactivation of CSF3 (G-CSF) signaling Inactivation of CSF3 (G-CSF) signaling FLT3 signaling through SRC family kinases
Drugs		Sargramostim NPI 32101 Resatorvid	1-Ter-Butyl-3-P-Tolyl-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine Phosphonotyrosine Quercetin Bosutinib Fostamatinib
Diseases
GWAS		Blood protein levels ( 30072576) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Perceived unattractiveness to mosquitoes ( 28199695)	Adult body size ( 32376654) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Inflammatory bowel disease ( 23128233) Liver enzyme levels (alkaline phosphatase) ( 33972514) Migraine ( 27322543)
Interacting Genes		27 interacting genes: CISH CSF2 CSF2RA EPOR FES FYN HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 RACK1 SHC1 STAT1 STAT3 SYK YWHAZ	117 interacting genes: ABL1 ABL2 ACTB ADAM15 AGK AGR2 APP AR ARRB1 ASAP1 BCAR1 BCR BPIFA1 BTK CBL CCDC88B CCR3 CD2AP CHST15 CREBBP CSF2RB CSF3R CSK CTAG1A CTAG1B CYB5D2 CYSRT1 DNM2 DOK1 DOK2 EGFR ELMO1 ERBB2 ERBB3 ERBB4 EVL FASLG FCGR1A FCGR2A FHL2 FHL5 GAB1 GOPC GRB14 HNRNPK HSF2BP IL6ST INCA1 INPP5D IRF2BPL KHDRBS1 KIT KPRP KRT31 KRT34 KRT35 KRT36 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-1 LCP2 LETMD1 LMNA MAP4K5 MDK MDM2 MET MID2 MKRN3 MTUS2 NBPF19 NGEF NOTCH2NLA PAK2 PECAM1 PIK3CB PIK3R1 PIK3R2 PLAUR PLCG1 PLCG2 PLEKHG4 PNMA1 PRRG4 RAPGEF1 RASA1 RASA3 RBPMS RPL10 SF3B3 SH2B2 SH3BP1 SH3KBP1 SKAP2 SOS1 SPRR2A STAT3 TEKT4 TEPSIN TNK2 TOX2 TP73 TRIM27 TRIP6 TRPV4 TSG101 UNC119 VAV1 WAS WDCP WIPF1 WNT2 ZSCAN4
Entrez ID		1439	3055
HPRD ID		00739	00796
Ensembl ID		ENSG00000100368	ENSG00000101336
Uniprot IDs		P32927 Q6NSJ8	A8K4G3 P08631
PDB IDs		1C8P 1EGJ 1GH7 2GYS 2NA8 2NA9 4NKQ 5DWU 8TLD	1AD5 1BU1 1QCF 2C0I 2C0O 2C0T 2HCK 2HK5 2OI3 2OJ2 3HCK 3NHN 3RBB 3REA 3REB 3VRY 3VRZ 3VS0 3VS1 3VS2 3VS3 3VS4 3VS5 3VS6 3VS7 4HCK 4LUD 4LUE 4ORZ 4U5W 5H09 5H0B 5H0E 5H0G 5H0H 5HCK 5NUH 5ZJ6 8F2P 9BYJ
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Phosphorylation Cell Surface Receptor Signaling Pathway Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Positive Regulation Of Signal Transduction Protein Modification Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Via STAT SH2 Domain Binding Kinase Activity Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphotyrosine Residue Binding Interleukin-3-mediated Signaling Pathway Regulation Of Signal Transduction Hemopoiesis Regulation Of Leukocyte Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Cytoplasmic Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Immune System Process Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Signaling Regulation Of Cell Communication Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Immune Response	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway SH3 Domain Binding Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Endocytosis Intracellular Signaling Cassette Cytosol Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Supramolecular Fiber Organization Regulation Of Programmed Cell Death Regulation Of Intracellular Signal Transduction Keratin Filament Immune Response-regulating Signaling Pathway Protein Tyrosine Kinase Activity ERBB Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Positive Regulation Of Immune System Process Protein Binding Regulation Of Signal Transduction Antigen Receptor-mediated Signaling Pathway Phosphotyrosine Residue Binding Intermediate Filament Regulation Of Immune System Process Plasma Membrane Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction Immune Response-activating Signaling Pathway T Cell Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Negative Regulation Of Programmed Cell Death Cell-cell Junction Developmental Process Regulation Of Cell Motility Regulation Of Immune Response Actin Filament Organization Activation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Response To Growth Factor Regulation Of Cell Migration Positive Regulation Of Cell Migration Regulation Of Locomotion Identical Protein Binding Endocytosis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?