CSF2RB and IL5RA

Number of citations of the paper that reports this interaction (PMID 9516124)
12

Data Source:
HPRD (in vivo)

		CSF2RB	IL5RA
Gene Name		colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)	interleukin 5 receptor, alpha
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex	Extracellular Space Plasma Membrane Integral Component Of Membrane
	Molecular Function	Receptor Activity Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding	Interleukin-5 Receptor Activity Protein Binding
	Biological Process	Signal Transduction Respiratory Gaseous Exchange Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway	Inflammatory Response To Antigenic Stimulus Signal Transduction Cell Proliferation Regulation Of Interleukin-5 Production Interleukin-5-mediated Signaling Pathway
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system GPCR downstream signaling Signaling by Interleukins Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs
Diseases
GWAS			Asthma (childhood onset) ( 22560479) Immune response to smallpox vaccine (IL-6) ( 22542470) Oleic acid (18:1n-9) plasma levels ( 23362303)
Protein-Protein Interactions		27 interactors: CISH CSF2 CSF2RA EPOR FES FYN GNB2L1 HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 SHC1 STAT1 STAT3 SYK YWHAZ	6 interactors: CSF2RB IL5 JAK1 JAK2 SDCBP UNC119
Entrez ID		1439	3568
HPRD ID		00739	00998
Ensembl ID		ENSG00000100368	ENSG00000091181
Uniprot IDs		B4DZL8 P32927 Q6NSJ8	Q01344 Q8NHV7
PDB IDs		1C8P 1EGJ 1GH7 2GYS 3CXE	1OBX 1OBZ 3QT2 3VA2
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Autophosphorylation Response To Organic Substance Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Immune Response Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Response To Cytokine Immune System Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Defense Response Regulation Of Immune Response Cellular Response To Peptide Hormone Stimulus Protein Autophosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Peptide Innate Immune Response Regulation Of Immune System Process Regulation Of JAK-STAT Cascade Regulation Of Signal Transduction JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Peptidyl-amino Acid Modification Signal Transduction Cellular Response To Growth Hormone Stimulus Regulation Of Cell Proliferation Cellular Response To Hormone Stimulus Intracellular Signal Transduction Regulation Of Signaling Response To Peptide Hormone Cellular Response To Organonitrogen Compound Immune Response-regulating Signaling Pathway Cell Migration Signaling Response To Peptide Cell Communication Leukocyte Migration Cellular Response To Stimulus Cell Motility Response To Growth Hormone Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Cellular Amino Acid Metabolic Process Phosphorylation Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein	Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Cytokine Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Organelle Assembly Positive Regulation Of Phosphorylation Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Secretion Regulation Of Cellular Amino Acid Metabolic Process Response To Antibiotic Positive Regulation Of JAK-STAT Cascade Signal Transduction Regulation Of Phosphorylation Regulation Of Cellular Ketone Metabolic Process Signaling Regulation Of Phosphorus Metabolic Process Cell Communication Regulation Of JAK-STAT Cascade Cell Surface Receptor Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Eosinophil Differentiation Host Programmed Cell Death Induced By Symbiont Negative Regulation Of Clathrin-mediated Endocytosis Histone H3-Y41 Phosphorylation Regulation Of Secretion Interferon-gamma-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To External Stimulus Cellular Response To Stimulus Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Negative Regulation Of Caveolin-mediated Endocytosis Mineralocorticoid Receptor Signaling Pathway Cellular Response To Organic Substance Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Cellular Response To Interferon-gamma Positive Regulation Of Growth Hormone Receptor Signaling Pathway Activation Of JAK2 Kinase Activity Interleukin-12-mediated Signaling Pathway Cytokinesis, Completion Of Separation Positive Regulation Of Intracellular Signal Transduction Response To Interferon-gamma Cell Migration Response To Toxic Substance Positive Regulation Of Extracellular Vesicular Exosome Assembly Interleukin-2-mediated Signaling Pathway
Tagcloud ?		11b affymetrix arrayed ccl2 ccl7 cdkn1a copg custom cxcl1 defining fourteen genechip glioma gliomas gliosarcomas grades icam igfbp immunotherapy portend saa4 sag sags senescence signature tnfrsf tnfsf translating u133	adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust fcer1a genotypic haplotype haplotypes house jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest
Tagcloud (Difference) ?		11b affymetrix arrayed ccl2 ccl7 cdkn1a copg custom cxcl1 defining fourteen genechip glioma gliomas gliosarcomas grades icam igfbp immunotherapy portend saa4 sag sags senescence signature tnfrsf tnfsf translating u133	adam33 allergen allergens allergic black boston cnot6 cockroach dataset dust fcer1a genotypic haplotype haplotypes house jak3 maml1 marginally mite nod1 rs11739089 rs12136904t rs6665683 rs6665683t rs7851969 sensitization sensitizations snps strongest
Tagcloud (Intersection) ?