CSF2RB and IL5RA

Number of citations: 0 (PubMedID 9516124)
Data Source: HPRD (in vivo)

		CSF2RB	IL5RA
Name		colony stimulating factor 2 receptor subunit beta	interleukin 5 receptor subunit alpha
Structure
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex	Extracellular Space Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity	Cytokine Receptor Activity Interleukin-5 Receptor Activity Protein Binding Cytokine Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Respiratory Gaseous Exchange By Respiratory System Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Leukocyte Proliferation	Inflammatory Response To Antigenic Stimulus Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Eosinophil Differentiation Regulation Of Interleukin-5 Production Interleukin-5-mediated Signaling Pathway Positive Regulation Of Leukocyte Proliferation
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Interleukin receptor SHC signaling
Drugs		Sargramostim NPI 32101 Resatorvid	Dimethyl sulfoxide Benralizumab
GWAS		Blood protein levels ( 30072576 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Inflammatory bowel disease ( 27569725 ) Itch intensity from mosquito bite ( 28199695 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Mosquito bite size ( 28199695 ) Multiple sclerosis ( 24076602 31604244 ) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376 ) Perceived unattractiveness to mosquitoes ( 28199695 )	Asthma (childhood onset) ( 22560479 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 32888494 27863252 ) Blood protein levels ( 30072576 ) Eosinophil count ( 32888494 27863252 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 32888494 27863252 ) Immune response to smallpox vaccine (IL-6) ( 22542470 ) Metabolite levels ( 23823483 ) Neutrophil percentage of granulocytes ( 27863252 ) Oleic acid (18:1n-9) levels ( 23362303 ) Sum eosinophil basophil counts ( 27863252 ) White blood cell count (basophil) ( 27863252 )
Interacting Genes		27 interacting genes: CISH CSF2 CSF2RA EPOR FES FYN HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 RACK1 SHC1 STAT1 STAT3 SYK YWHAZ	7 interacting genes: CSF2RB EGFR IL5 JAK1 JAK2 SDCBP UNC119
Entrez ID		1439	3568
HPRD ID		00739	00998
Ensembl ID		ENSG00000100368	ENSG00000091181
Uniprot IDs		P32927 Q6NSJ8	Q01344 Q8NHV7
PDB IDs		1C8P 1EGJ 1GH7 2GYS 2NA8 2NA9 4NKQ 5DWU 8TLD	1OBX 1OBZ 3QT2 3VA2 6H41 8TLD
GO Terms Enriched among Interactors		Cytokine-mediated Signaling Pathway Phosphorylation Cell Surface Receptor Signaling Pathway Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Positive Regulation Of Signal Transduction Protein Modification Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Via STAT SH2 Domain Binding Kinase Activity Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphotyrosine Residue Binding Interleukin-3-mediated Signaling Pathway Regulation Of Signal Transduction Hemopoiesis Regulation Of Leukocyte Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Cytoplasmic Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Immune System Process Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Signaling Regulation Of Cell Communication Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Immune Response	Interleukin-5-mediated Signaling Pathway Interleukin-5 Receptor Binding Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Interleukin-3-mediated Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Interleukin-3 Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Phosphate Metabolic Process Growth Hormone Receptor Binding Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Focal Adhesion Regulation Of Phosphorylation Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Protein Tyrosine Kinase Activity Type II Interferon-mediated Signaling Pathway Growth Hormone Receptor Signaling Pathway Via JAK-STAT Interleukin-6-mediated Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Positive Regulation Of Leukocyte Proliferation Regulation Of Phosphorus Metabolic Process Growth Hormone Receptor Signaling Pathway Signal Transduction Membrane Raft Negative Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Protein Phosphorylation Response To Antibiotic Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Leukocyte Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Receptor Signaling Pathway Via STAT Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Multivesicular Body, Internal Vesicle Lumen Regulation Of Receptor Signaling Pathway Via JAK-STAT Interferon-mediated Signaling Pathway Cellular Response To Virus Histone H3Y41 Kinase Activity Nuclear Receptor-mediated Mineralocorticoid Signaling Pathway Symbiont-induced Defense-related Programmed Cell Death Interleukin-35-mediated Signaling Pathway Negative Regulation Of Endocytosis Interleukin-5 Receptor Complex Cellular Response To Cytokine Stimulus