CSF2RB and CSF2RA

Number of citations of the paper that reports this interaction (PubMedID 9211889)
0

Data Source:
HPRD (in vitro, in vivo)

		CSF2RB	CSF2RA
Description		colony stimulating factor 2 receptor subunit beta	colony stimulating factor 2 receptor subunit alpha
Image
GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex	Extracellular Region Cytosol Plasma Membrane External Side Of Plasma Membrane Membrane Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Growth Hormone Receptor Complex
	Molecular Function	Cytokine Receptor Activity Interleukin-3 Receptor Activity Interleukin-5 Receptor Activity Protein Binding Coreceptor Activity Signaling Receptor Activity	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Peptide Hormone Binding Cytokine Binding Signaling Receptor Activity
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Respiratory Gaseous Exchange By Respiratory System Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Cellular Response To Interleukin-3 Interleukin-5-mediated Signaling Pathway Interleukin-3-mediated Signaling Pathway Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Leukocyte Proliferation	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Growth Hormone Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation
Pathways		Interleukin-3, Interleukin-5 and GM-CSF signaling Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling	Interleukin-3, Interleukin-5 and GM-CSF signaling RAF/MAP kinase cascade Surfactant metabolism Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4 Interleukin receptor SHC signaling
Drugs		Sargramostim NPI 32101 Resatorvid	Sargramostim KB002 Regramostim Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Clove oil
Diseases
GWAS		Blood protein levels ( 30072576) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Femur bone mineral density x serum urate levels interaction ( 34046847) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Multiple sclerosis ( 24076602 31604244) Multiple sclerosis and LDL levels (pleiotropy) ( 26920376) Perceived unattractiveness to mosquitoes ( 28199695)	Mitochondrial heteroplasmy measurement ( 33731350) Schizophrenia ( 17522711)
Interacting Genes		27 interacting genes: CISH CSF2 CSF2RA EPOR FES FYN HCK IKBKB IL3 IL3RA IL5RA JAK1 JAK2 KDR KIT LCK LYN MAD2L1 PRKCB PTPN11 PTPN6 RACK1 SHC1 STAT1 STAT3 SYK YWHAZ	9 interacting genes: CHUK CSF2 CSF2RB FATE1 IKBKB KIT LYN PIK3R1 RPSA
Entrez ID		1439	1438
HPRD ID		00739	02381
Ensembl ID		ENSG00000100368	ENSG00000198223
Uniprot IDs		P32927 Q6NSJ8	P15509
PDB IDs		1C8P 1EGJ 1GH7 2GYS 2NA8 2NA9 4NKQ 5DWU 8TLD	4NKQ 4RS1
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Phosphorylation Cell Surface Receptor Signaling Pathway Protein Phosphorylation Peptidyl-tyrosine Phosphorylation Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Positive Regulation Of Cell Population Proliferation Fc Receptor Signaling Pathway Regulation Of Developmental Process Enzyme-linked Receptor Protein Signaling Pathway Protein Kinase Activity Positive Regulation Of Signal Transduction Protein Modification Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Regulation Of Multicellular Organismal Development Cell Surface Receptor Signaling Pathway Via STAT SH2 Domain Binding Kinase Activity Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphotyrosine Residue Binding Interleukin-3-mediated Signaling Pathway Regulation Of Signal Transduction Hemopoiesis Regulation Of Leukocyte Proliferation Positive Regulation Of Multicellular Organismal Process Growth Hormone Receptor Signaling Pathway Cytoplasmic Side Of Plasma Membrane Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Immune System Process Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway Positive Regulation Of Developmental Process Regulation Of Anatomical Structure Morphogenesis Regulation Of Signaling Regulation Of Cell Communication Antigen Receptor-mediated Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Proliferation Immune Response	Cytokine-mediated Signaling Pathway Cytoplasmic Side Of Plasma Membrane Immune System Process Immune Response Response To External Biotic Stimulus Myeloid Leukocyte Differentiation IkappaB Kinase Activity Regulation Of Cytokine Production Positive Regulation Of Leukocyte Proliferation Granulocyte-macrophage Colony-stimulating Factor Signaling Pathway Granulocyte Macrophage Colony-stimulating Factor Receptor Complex Positive Regulation Of Mast Cell Proliferation Fc Receptor Signaling Pathway Interleukin-5-mediated Signaling Pathway Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Scaffold Protein Binding IkappaB Kinase Complex Myeloid Cell Differentiation Histamine Secretion Phosphatidylinositol 3-kinase Activator Activity Regulation Of Mast Cell Proliferation Innate Immune Response Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Proliferation Histamine Transport CD40 Receptor Complex Transferrin Receptor Binding Mononuclear Cell Differentiation Defense Response Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of DNA-binding Transcription Factor Activity Leukocyte Differentiation Immune Effector Process Immune Response-regulating Signaling Pathway Cellular Response To Cytokine Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Innate Immune Response Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Immune Response Fc-epsilon Receptor Signaling Pathway Growth Hormone Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Immune System Process Protein Kinase Activity Positive Regulation Of Cytokine Production Innate Immune Response-activating Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity
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