TRPC4

Description		transient receptor potential cation channel subfamily C member 4
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GO Annotations	Cellular Component	Plasma Membrane Caveola Cell-cell Junction Cell Surface Membrane Basolateral Plasma Membrane Cortical Cytoskeleton Protein-containing Complex Cation Channel Complex Calcium Channel Complex Membrane Raft
	Molecular Function	Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Gamma-aminobutyric Acid Secretion Monoatomic Ion Transmembrane Transport Oligodendrocyte Differentiation Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport
Pathways		TRP channels Role of second messengers in netrin-1 signaling
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Mild influenza (H1N1) infection ( 26379185) Obesity-related traits ( 23251661) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		10 interacting genes: DRD2 ITCH ITPR1 ITPR2 ITPR3 MX1 NHERF1 TJP1 TRPC1 TRPC5
Entrez ID		7223
HPRD ID		09154
Ensembl ID		ENSG00000133107
Uniprot IDs		Q9UBN4
PDB IDs		8WPL 8WPM 8WPN
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Ion Transmembrane Transport Calcium Channel Activity Calcium Ion Transport Regulation Of Sequestering Of Calcium Ion Metal Ion Transport Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Monoatomic Ion Channel Activity Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Monoatomic Cation Transport Inorganic Ion Homeostasis Calcium Ion Homeostasis Monoatomic Ion Transport Calcium Ion Transmembrane Import Into Cytosol Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Transmembrane Transport Inorganic Ion Transmembrane Transport Homeostatic Process Monoatomic Ion Transmembrane Transport Plasma Membrane Chemical Homeostasis Intracellular Calcium Ion Homeostasis Transport Vesicle Membrane Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Regulation Of Cytosolic Calcium Ion Concentration Intracellular Chemical Homeostasis Sarcoplasmic Reticulum Phospholipase C-activating Dopamine Receptor Signaling Pathway Store-operated Calcium Channel Activity Apical Part Of Cell Cellular Homeostasis Calcium Ion Transmembrane Transporter Activity Secretory Granule Membrane Phosphatidylinositol Binding Cellular Response To Ethanol G Protein-coupled Receptor Signaling Pathway Cation Channel Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Membrane Acid Secretion Calcium-mediated Signaling Receptor Complex
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