TRPC4 and MX1

Number of citations of the paper that reports this interaction (PubMedID 15757897)
0

Data Source:
HPRD (in vitro, in vivo)

		TRPC4	MX1
Description		transient receptor potential cation channel subfamily C member 4	MX dynamin like GTPase 1
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GO Annotations	Cellular Component	Plasma Membrane Caveola Cell-cell Junction Cell Surface Membrane Basolateral Plasma Membrane Cortical Cytoskeleton Protein-containing Complex Cation Channel Complex Calcium Channel Complex Membrane Raft	Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Microtubule Plasma Membrane Membrane Nuclear Membrane Synapse Perinuclear Region Of Cytoplasm Presynapse
	Molecular Function	Monoatomic Ion Channel Activity Calcium Channel Activity Protein Binding Beta-catenin Binding Store-operated Calcium Channel Activity Cadherin Binding Inositol 1,4,5 Trisphosphate Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Microtubule Binding Identical Protein Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Gamma-aminobutyric Acid Secretion Monoatomic Ion Transmembrane Transport Oligodendrocyte Differentiation Regulation Of Cytosolic Calcium Ion Concentration Transmembrane Transport Calcium Ion Import Calcium Ion Transmembrane Transport	Immune System Process Apoptotic Process Defense Response Signal Transduction Response To Virus Synaptic Vesicle Budding From Presynaptic Endocytic Zone Membrane Response To Type I Interferon Negative Regulation Of Viral Genome Replication Innate Immune Response Defense Response To Virus Interleukin-27-mediated Signaling Pathway Antiviral Innate Immune Response
Pathways		TRP channels Role of second messengers in netrin-1 signaling	ISG15 antiviral mechanism Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23326517) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Mild influenza (H1N1) infection ( 26379185) Obesity-related traits ( 23251661) Smoking initiation ( 30617275 33082346) Smoking initiation (ever regular vs never regular) ( 30679032) Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		10 interacting genes: DRD2 ITCH ITPR1 ITPR2 ITPR3 MX1 NHERF1 TJP1 TRPC1 TRPC5	42 interacting genes: ACTB ADRM1 APP BLM BRD7 C7orf25 CAB39L CASP8AP2 CBX4 CHD3 DAXX EPM2AIP1 FANCA FXR1 GMEB1 HMGXB4 KIF26B KLHL35 LRRC4B MCCD1 PIAS1 PIAS2 PLRG1 PSD3 RELA SIAH1 SIRPA SLC25A3 SP100 TDG TRPC1 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TUBA1A TUBB ZBTB16 ZCCHC12 ZNF251 ZNF623
Entrez ID		7223	4599
HPRD ID		09154	00919
Ensembl ID		ENSG00000133107	ENSG00000157601
Uniprot IDs		Q9UBN4	H9KVC7 P20591
PDB IDs		8WPL 8WPM 8WPN	3LJB 3SZR 3ZYS 4P4S 4P4T 4P4U 5GTM
Enriched GO Terms of Interacting Partners?		Inositol 1,4,5 Trisphosphate Binding Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Calcium Ion Transmembrane Transport Calcium Channel Activity Calcium Ion Transport Regulation Of Sequestering Of Calcium Ion Metal Ion Transport Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Monoatomic Ion Channel Activity Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Monoatomic Cation Transport Inorganic Ion Homeostasis Calcium Ion Homeostasis Monoatomic Ion Transport Calcium Ion Transmembrane Import Into Cytosol Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport Transmembrane Transport Inorganic Ion Transmembrane Transport Homeostatic Process Monoatomic Ion Transmembrane Transport Plasma Membrane Chemical Homeostasis Intracellular Calcium Ion Homeostasis Transport Vesicle Membrane Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Regulation Of Cytosolic Calcium Ion Concentration Intracellular Chemical Homeostasis Sarcoplasmic Reticulum Phospholipase C-activating Dopamine Receptor Signaling Pathway Store-operated Calcium Channel Activity Apical Part Of Cell Cellular Homeostasis Calcium Ion Transmembrane Transporter Activity Secretory Granule Membrane Phosphatidylinositol Binding Cellular Response To Ethanol G Protein-coupled Receptor Signaling Pathway Cation Channel Complex Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Intracellular Monoatomic Cation Homeostasis Intracellular Monoatomic Ion Homeostasis G Protein-coupled Dopamine Receptor Signaling Pathway Membrane Acid Secretion Calcium-mediated Signaling Receptor Complex	Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding Cation Channel Complex PML Body Regulation Of Cytosolic Calcium Ion Concentration Calcium Channel Activity Transcription Corepressor Activity Cytoplasmic Ribonucleoprotein Granule SUMO Ligase Activity Actinin Binding Negative Regulation Of Cytokine Production Involved In Inflammatory Response Monoatomic Ion Channel Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Calcium Ion Homeostasis SUMO Transferase Activity Calcium Ion Transmembrane Transport Calcium Ion Homeostasis Regulation Of Presynapse Organization Regulation Of Presynapse Assembly Positive Regulation Of Cell-cell Adhesion Negative Regulation Of RNA Metabolic Process Calcium Ion Transport Regulation Of Cytokine Production Involved In Inflammatory Response Nucleus Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Cell Development Regulation Of T Cell Activation Identical Protein Binding Regulation Of T Cell Differentiation Intracellular Monoatomic Cation Homeostasis Associative Learning Inorganic Ion Homeostasis Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Biosynthetic Process Protein Homodimerization Activity Intracellular Monoatomic Ion Homeostasis Negative Regulation Of Dendrite Morphogenesis Positive Regulation Of Cell Differentiation Regulation Of Synapse Organization Ubiquitin Protein Ligase Binding Regulation Of Multicellular Organismal Development Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Nuclear Envelope Lumen SUMO Binding Synapse Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of MiRNA-mediated Gene Silencing
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