CD47 and SIRPA

Number of citations of the paper that reports this interaction (PMID 9872987)
49

Data Source:
HPRD (in vitro)

		CD47	SIRPA
Gene Name		CD47 molecule	signal-regulatory protein alpha
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome	Plasma Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Thrombospondin Receptor Activity	SH3 Domain Binding
	Biological Process	Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Opsonization Positive Regulation Of Cell Proliferation Response To Bacterium Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Leukocyte Migration	Cell Adhesion Blood Coagulation Leukocyte Migration
Pathways		Integrin cell surface interactions Signal regulatory protein (SIRP) family interactions Cell surface interactions at the vascular wall	Signal regulatory protein (SIRP) family interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS			Aortic root size ( 21223598) Mean platelet volume ( 22139419 19820697)
Protein-Protein Interactions		12 interactors: BNIP3 EPB42 FAS GNAI1 ITGAV P2RY2 PTK2 RHAG SIRPA SYNE4 THBS1 UBQLN1	12 interactors: CCDC57 CD47 IL1RAP JAK2 KRT15 KRT31 KRT40 NOL3 PTPN11 PTPN6 TRIM2 TRIM27
Entrez ID		961	140885
HPRD ID		03017	03912
Ensembl ID		ENSG00000196776	ENSG00000198053
Uniprot IDs		Q08722	P78324
PDB IDs		2JJS 2JJT 2VSC 4KJY	2JJS 2JJT 2UV3 2WNG
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Immune System Process Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cellular Response To Oxygen Levels Regulation Of Apoptotic Process Cellular Response To Inorganic Substance Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Stress Negative Regulation Of Lipid Transport Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Cell Death Death Platelet Activation Response To Hyperoxia Apoptotic Cell Clearance Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Regulation Of Cellular Component Organization Erythrocyte Development Homeostasis Of Number Of Cells Peptide Cross-linking Spleen Development Regulation Of Focal Adhesion Assembly Phagocytosis Cell Activation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Apoptotic Process Response To Hypoxia Regulation Of Cell Junction Assembly Cell Differentiation Neuron Death Angiogenesis Response To Metal Ion Positive Regulation Of Cell Migration Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Cell Motility Cell Migration Apoptotic Signaling Pathway	Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Abortive Mitotic Cell Cycle Response To Wounding Positive Regulation Of Cell Activation Regulation Of Cytokine-mediated Signaling Pathway Innate Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Interferon-gamma-mediated Signaling Pathway Megakaryocyte Development Blood Coagulation Hemostasis Cytokine-mediated Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Cell Activation Platelet Formation Platelet Morphogenesis Megakaryocyte Differentiation JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interferon-gamma Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Regulation Of Body Fluid Levels Cellular Response To Cytokine Stimulus Negative Regulation Of Cell Adhesion Wound Healing Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Regulation Of Cell Adhesion Immune System Process Immune Response Regulation Of Immune System Process Leukocyte Migration Negative Regulation Of Adaptive Immune Response Response To Stress Defense Response Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Response To Growth Hormone Myeloid Cell Differentiation Regulation Of Type I Interferon-mediated Signaling Pathway Response To Cytokine Regulation Of Protein Kinase Activity Platelet-derived Growth Factor Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of T Cell Activation Regulation Of Kinase Activity JAK-STAT Cascade
Tagcloud ?		1p34 ancestral asymmetry bilayer connecting deduced duffy ee glycophorin glycoproteins glycosylated helices hydrophilic leaflets loops lw multimeric occasions phospholipid primates reside rh rh50 rhce rhd rhnull specificities suffer topology	accelerated cd47 concert demonstrates diabetogenic displayed drive drives enables encodes idd13 idd5 immunopathogenesis insight insulitis islet locus mechanistic nod paired potency potentiate recapitulates restricted t1d transgene variations
Tagcloud (Difference) ?		1p34 ancestral asymmetry bilayer connecting deduced duffy ee glycophorin glycoproteins glycosylated helices hydrophilic leaflets loops lw multimeric occasions phospholipid primates reside rh rh50 rhce rhd rhnull specificities suffer topology	accelerated concert demonstrates diabetogenic displayed drive drives enables encodes idd13 idd5 immunopathogenesis insight insulitis islet locus mechanistic nod paired potency potentiate recapitulates restricted t1d transgene variations
Tagcloud (Intersection) ?		cd47