CD47 and BNIP3

Number of citations of the paper that reports this interaction (PMID 12690108)
14

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		CD47	BNIP3
Gene Name		CD47 molecule	BCL2/adenovirus E1B 19kDa interacting protein 3
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Extracellular Vesicular Exosome	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Dendrite Integral Component Of Mitochondrial Outer Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Thrombospondin Receptor Activity	Protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity GTPase Binding
	Biological Process	Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Opsonization Positive Regulation Of Cell Proliferation Response To Bacterium Positive Regulation Of Cell-cell Adhesion Extracellular Matrix Organization Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Leukocyte Migration	Response To Hypoxia Apoptotic Process Cell Death Granzyme-mediated Apoptotic Signaling Pathway Positive Regulation Of Autophagy Negative Regulation Of Mitochondrial Fusion Viral Process Mitochondrial Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Complex Disassembly Mitochondrial Fragmentation Involved In Apoptotic Process Negative Regulation Of Membrane Potential Regulation Of Mitochondrial Membrane Permeability Autophagic Cell Death Brown Fat Cell Differentiation Neuron Apoptotic Process Defense Response To Virus Response To Hyperoxia Cellular Response To Hydrogen Peroxide Cellular Response To Mechanical Stimulus Cellular Response To Cobalt Ion Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Positive Regulation Of Mitochondrial Fission Positive Regulation Of Release Of Cytochrome C From Mitochondria Mitochondrial Outer Membrane Permeabilization Toxin Transport Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia
Pathways		Integrin cell surface interactions Signal regulatory protein (SIRP) family interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: BNIP3 EPB42 FAS GNAI1 ITGAV P2RY2 PTK2 RHAG SIRPA SYNE4 THBS1 UBQLN1	15 interactors: BCL2 BCL2L1 BNIP3L CD47 CLEC7A CLN8 FATE1 HIVEP1 KTN1 LDLRAD1 MAP1LC3B NCBP1 RHEB TGM2 TMEM11
Entrez ID		961	664
HPRD ID		03017	04482
Ensembl ID		ENSG00000196776
Uniprot IDs		Q08722	Q12983
PDB IDs		2JJS 2JJT 2VSC 4KJY	2J5D 2KA1 2KA2
Enriched GO Terms of Interacting Partners?		Blood Coagulation Hemostasis Immune System Process Regulation Of Body Fluid Levels Wound Healing Response To Wounding Cellular Response To Oxygen Levels Regulation Of Apoptotic Process Cellular Response To Inorganic Substance Regulation Of Cell Death Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Response To Stress Negative Regulation Of Lipid Transport Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Cell Death Death Platelet Activation Response To Hyperoxia Apoptotic Cell Clearance Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Mechanical Stimulus Regulation Of Cellular Component Organization Erythrocyte Development Homeostasis Of Number Of Cells Peptide Cross-linking Spleen Development Regulation Of Focal Adhesion Assembly Phagocytosis Cell Activation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Apoptotic Process Response To Hypoxia Regulation Of Cell Junction Assembly Cell Differentiation Neuron Death Angiogenesis Response To Metal Ion Positive Regulation Of Cell Migration Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Entry Of Bacterium Into Host Cell Negative Regulation Of Dendritic Cell Antigen Processing And Presentation Entry Of Symbiont Into Host Cell By Promotion Of Host Phagocytosis Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Positive Regulation Of Cell Motility Cell Migration Apoptotic Signaling Pathway	Mitochondrion Organization Mitochondrial Membrane Organization Regulation Of Mitochondrial Membrane Permeability Regulation Of Membrane Permeability Apoptotic Mitochondrial Changes Response To Other Organism Negative Regulation Of Anoikis Response To Biotic Stimulus Regulation Of Anoikis Membrane Organization Mitochondrial Transport Release Of Cytochrome C From Mitochondria Negative Regulation Of Autophagy Regulation Of Mitochondrial Membrane Potential Endoplasmic Reticulum Calcium Ion Homeostasis Response To External Stimulus Positive Regulation Of Apoptotic Process Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Programmed Cell Death Transport Positive Regulation Of Cell Death Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Virus Endocytosis Response To Gamma Radiation Phagocytosis Neuron Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Death Negative Regulation Of Cellular PH Reduction CD8-positive, Alpha-beta T Cell Lineage Commitment Apoptotic Process In Bone Marrow Negative Regulation Of Retinal Cell Programmed Cell Death Ovarian Follicle Development Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of Cell Proliferation Regulation Of Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Stress Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine L-glutamate Uptake Involved In Synaptic Transmission Negative Regulation Of Apoptotic Process Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Programmed Cell Death Positive Regulation Of Inflammatory Response Ovulation Cycle Process
Tagcloud ?		1p34 ancestral asymmetry bilayer connecting deduced duffy ee glycophorin glycoproteins glycosylated helices hydrophilic leaflets loops lw multimeric occasions phospholipid primates reside rh rh50 rhce rhd rhnull specificities suffer topology	accepted atg autophagy biomedical carbohydrate comprehensive discovery distributed diverse elucidating families great interest interesting lectins modulating origin perspective pharmacological plant problems raf representative respect summarize thousands ubiquitously widely working
Tagcloud (Difference) ?		1p34 ancestral asymmetry bilayer connecting deduced duffy ee glycophorin glycoproteins glycosylated helices hydrophilic leaflets loops lw multimeric occasions phospholipid primates reside rh rh50 rhce rhd rhnull specificities suffer topology	accepted atg autophagy biomedical carbohydrate comprehensive discovery distributed diverse elucidating families great interest interesting lectins modulating origin perspective pharmacological plant problems raf representative respect summarize thousands ubiquitously widely working
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