ARHGAP5 and RND3

Number of citations of the paper that reports this interaction (PubMedID 12842009)
44

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down, affinity chromatography technology)
HPRD (two hybrid, in vitro, in vivo)

		ARHGAP5	RND3
Description		Rho GTPase activating protein 5	Rho family GTPase 3
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Membrane	Golgi Membrane Golgi Apparatus Cytosol Plasma Membrane Focal Adhesion Membrane
	Molecular Function	GTPase Activity GTPase Activator Activity Protein Binding SH2 Domain Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Cell Adhesion Signal Transduction Rho Protein Signal Transduction Regulation Of Cell Size Epithelial Cell Migration Positive Regulation Of Epithelial Cell Migration Cell Migration Mammary Gland Development Regulation Of Small GTPase Mediated Signal Transduction	Actin Filament Organization Cell Adhesion Signal Transduction Small GTPase-mediated Signal Transduction Actin Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	RND3 GTPase cycle
Drugs			Guanosine-5'-Triphosphate
Diseases
GWAS		Asthma ( 29273806)	Arterial stiffness (brachial-ankle pulse wave velocity) ( 32790701) Daytime nap ( 33568662) Endometriosis ( 23472165) Esophageal adenocarcinoma x gastroesophageal reflux disease interaction ( 29551738) Femur bone mineral density x serum urate levels interaction ( 34046847) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Neonatal total 25-hydroxyvitamin D levels (fetal genetic effect) ( 32047095) Platelet count ( 31217584) Reticulocyte fraction of red cells ( 32888494) Type 2 diabetes ( 22238593) Urinary metabolite levels in chronic kidney disease ( 29545352)
Interacting Genes		12 interacting genes: ADRB2 CSDE1 FGF13 HSPA13 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND3 SMURF2	9 interacting genes: ARHGAP5 C14orf119 CFTR CIT CPLANE2 PLXNB1 ROCK1 SKP2 UBXN11
Entrez ID		394	390
HPRD ID		04060	04233
Ensembl ID		ENSG00000100852	ENSG00000115963
Uniprot IDs		Q13017	B2R838 P61587
PDB IDs		2EE4 2EE5 5U4V	1M7B 2V55 4BG6 7OBC 7OBD 8B2K 8BFC
Enriched GO Terms of Interacting Partners?		Integrin Alpha5-beta1 Complex Wound Healing, Spreading Of Cells Regulation Of Developmental Process Focal Adhesion Cell-cell Adhesion Mediated By Integrin Anatomical Structure Formation Involved In Morphogenesis Plasma Membrane Regulation Of Cell-substrate Adhesion CD40 Signaling Pathway Regulation Of Cytoskeleton Organization Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Ruffle Membrane Integrin-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Cell-matrix Adhesion Angiogenesis Ruffle Cell Differentiation Negative Regulation Of Anoikis Regulation Of Actin Cytoskeleton Organization Regulation Of Cell-matrix Adhesion Signal Transduction Regulation Of Organelle Organization Contractile Actin Filament Bundle Assembly Stress Fiber Assembly Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Bone Resorption Blood Vessel Diameter Maintenance Regulation Of Tube Size Cell-substrate Adhesion Regulation Of Supramolecular Fiber Organization Neuron Migration Regulation Of Actin Filament-based Process Regulation Of Anoikis Integrin Complex Cell Adhesion Mediated By Integrin LncRNA Binding Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Developmental Process Cerebral Cortex Cell Migration Response To Muscle Activity Positive Regulation Of Excitatory Postsynaptic Potential Cell Surface Receptor Signaling Pathway Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Apoptotic Process Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Angiogenesis	Regulation Of Establishment Of Endothelial Barrier Regulation Of Establishment Of Cell Polarity Regulation Of Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Communication Regulation Of Signaling Epithelial Cell Migration Regulation Of Endothelial Cell Differentiation Regulation Of Cytoskeleton Organization Regulation Of Intracellular Signal Transduction Regulation Of Organelle Organization Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding GTP Cyclohydrolase I Activity Rho Protein Signal Transduction Mitotic Cytokinesis GTPase Activity Regulation Of Signal Transduction Positive Regulation Of Anion Channel Activity PDZ Domain Binding Rho-dependent Protein Serine/threonine Kinase Activity Cell Migration Cell Adhesion Membrane Docking Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Nitric-oxide Synthase Activity Cytoskeleton-dependent Cytokinesis Regulation Of Cell Motility Ameboidal-type Cell Migration Regulation Of Locomotion Regulation Of Biological Quality Cell Motility Regulation Of Cell Migration Positive Regulation Of Establishment Of Endothelial Barrier Cell-cell Adhesion Protein Localization To Bicellular Tight Junction Blood Vessel Maturation Positive Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Fibrinogen Binding Regulation Of Epithelial Cell Differentiation Nucleotide Binding Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization
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