ARHGAP5 and RND3

Number of citations of the paper that reports this interaction (PMID 12842009)
43

Data Source:
BioGRID (two hybrid, affinity chromatography technology, pull down)
HPRD (in vitro, in vivo, two hybrid)

		ARHGAP5	RND3
Gene Name		Rho GTPase activating protein 5	Rho family GTPase 3
Image
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Membrane	Golgi Membrane Focal Adhesion Extracellular Vesicular Exosome
	Molecular Function	GTPase Activity Rho GTPase Activator Activity Protein Binding GTP Binding SH2 Domain Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Positive Regulation Of Mesenchymal Cell Proliferation Cell Adhesion Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Metabolic Process Regulation Of Cell Size Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of Rho GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction	Cell Adhesion Small GTPase Mediated Signal Transduction Metabolic Process Actin Cytoskeleton Organization
Pathways		Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS			Endometriosis ( 23472165) Type 2 diabetes ( 22238593)
Protein-Protein Interactions		11 interactors: ADRB2 ITGA5 ITGB1 PTK2B PTPN18 RASA1 RHOA RND1 RND2 RND3 SMURF2	7 interactors: ARHGAP5 CIT PLXNB1 ROCK1 SKP2 UBC UBXN11
Entrez ID		394	390
HPRD ID		04060	04233
Ensembl ID		ENSG00000100852	ENSG00000115963
Uniprot IDs		Q13017	B2R838 P61587
PDB IDs		2EE4 2EE5	1M7B 2V55 4BG6
Enriched GO Terms of Interacting Partners?		Axon Guidance Neuron Projection Development Regulation Of Cell-substrate Adhesion Cell Junction Assembly Generation Of Neurons Neuron Development Neurogenesis Axonogenesis Positive Regulation Of Neuron Projection Development Signal Transduction Axon Development Cell Morphogenesis Involved In Neuron Differentiation Response To External Stimulus Actin Cytoskeleton Organization Neuron Differentiation Chemotaxis Cell-cell Adhesion Mediated By Integrin Regulation Of Cell Adhesion Cell Projection Organization Signaling Positive Regulation Of Cell Projection Organization Neuron Projection Morphogenesis Actin Filament-based Process Cell Communication Locomotion Positive Regulation Of Signal Transduction Cell Morphogenesis Involved In Differentiation Positive Regulation Of Neuron Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Adhesion Mediated By Integrin Positive Regulation Of Cell-substrate Adhesion Nervous System Development Integrin-mediated Signaling Pathway Regulation Of Neuron Projection Development Cell Differentiation Movement Of Cell Or Subcellular Component Negative Regulation Of Anoikis Cell Projection Morphogenesis Cellular Response To Stimulus Cell Part Morphogenesis Positive Regulation Of Neurogenesis Blood Vessel Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Anoikis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cell Morphogenesis Blood Vessel Endothelial Cell Migration Heterotypic Cell-cell Adhesion Regulation Of Cell Projection Organization Positive Regulation Of Cell Development	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process G2/M Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cellular Macromolecule Catabolic Process Intracellular Signal Transduction Rho Protein Signal Transduction Regulation Of Cytoskeleton Organization Proteolysis Cellular Response To Cell-matrix Adhesion Mitotic Cell Cycle Process G1/S Transition Of Mitotic Cell Cycle Catabolic Process Mitotic Cell Cycle Protein Polyubiquitination Cell Communication Neuron Projection Development Membrane To Membrane Docking Semaphorin-plexin Signaling Pathway Involved In Bone Trabecula Morphogenesis Apical Constriction Ras Protein Signal Transduction Regulation Of Organelle Organization Positive Regulation Of Cell Cycle Process Regulation Of Cell Cycle Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Neuron Development Positive Regulation Of Rho GTPase Activity Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Dendrite Morphogenesis Cellular Response To Stimulus Cell Cycle Process Regulation Of Rho GTPase Activity Regulation Of Catalytic Activity Positive Regulation Of Cell Cycle Bleb Assembly Cellular Protein Metabolic Process Positive Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Viral Protein Processing Neuron Differentiation Cell Projection Organization Negative Regulation Of Osteoblast Proliferation Myoblast Migration Regulation Of Cellular Component Size
Tagcloud ?		10a 200c 30a 30c cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3	128a adjacent b1 bioinformatics blotting cdk4 dual expressions fresh hcc hepatocellular luciferase microrna mimics mir mtt nineteen pairs promoted promotes qrt reporter software targeting tissues transfected transfection utr viability
Tagcloud (Difference) ?		10a 200c 30a 30c cd36 cdh2 cdk5r1 chips cyp27b1 figure gemcitabine gna13 gp5 hist1h2bf hlf igsf3 ikbkb il32 intriguing mirs nrp2 oxidoreductase pak7 putatively rab23 rap2a slc11a1 sod3 tp53i3	128a adjacent b1 bioinformatics blotting cdk4 dual expressions fresh hcc hepatocellular luciferase microrna mimics mir mtt nineteen pairs promoted promotes qrt reporter software targeting tissues transfected transfection utr viability
Tagcloud (Intersection) ?