UFL1 and ENY2

Number of citations of the paper that reports this interaction (PubMedID 32545848)
54

Data Source:
BioGRID (two hybrid)

		UFL1	ENY2
Description		UFM1 specific ligase 1	ENY2 transcription and export complex 2 subunit
Image
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Protein-containing Complex Site Of Double-strand Break Neuron Projection	SAGA Complex Nucleus Nuclear Pore Nucleoplasm Mitochondrion Transcription Factor TFTC Complex Nuclear Pore Nuclear Basket Transcription Export Complex 2 DUBm Complex
	Molecular Function	Protein Binding Transferase Activity Protein Kinase Binding UFM1 Ligase Activity UFM1 Transferase Activity	Chromatin Binding Transcription Coactivator Activity Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Osteoblast Differentiation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Repair DNA Damage Response Blood Circulation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Autophagy Erythrocyte Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Disassembly Regulation Of Protein Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Regulation Of Inflammatory Response Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Hematopoietic Stem Cell Differentiation Positive Regulation Of Glial Cell Proliferation Reticulophagy Protein Ufmylation Rescue Of Stalled Ribosome Antiviral Innate Immune Response Positive Regulation Of Reticulophagy Negative Regulation Of Signal Transduction By P53 Class Mediator Response To L-glutamate Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of IRE1-mediated Unfolded Protein Response Protein K69-linked Ufmylation	Regulation Of DNA Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II MRNA Export From Nucleus Protein Transport Poly(A)+ MRNA Export From Nucleus Regulation Of RNA Splicing Positive Regulation Of DNA-templated Transcription MRNA Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	HATs acetylate histones
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Headache ( 29397368) Language functional connectivity ( 34929384) Migraine ( 27322543) Migraine without aura ( 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Walking pace ( 33128006)	Metabolite levels ( 23823483) Multiple system atrophy (pathologically confirmed) ( 27629089) Night sleep phenotypes ( 27126917)
Interacting Genes		17 interacting genes: AHCY AKAP17A ATP4A ENY2 FGB H2AC4 HINFP IRAK1BP1 IRF3 MT1M PPIL1 PTPRO TIPRL TP53 TSC22D3 UFC1 ZNF219	7 interacting genes: APP ATXN7L3B CEBPA CSTPP1 HNRNPA2B1 MCM3AP UFL1
Entrez ID		23376	56943
HPRD ID		11109	13121
Ensembl ID		ENSG00000014123	ENSG00000120533
Uniprot IDs		O94874	Q9NPA8
PDB IDs		8B9X 8C0D 8OHD 8OJ0 8OJ5 8OJ8 8QFC 8QFD	4DHX
Enriched GO Terms of Interacting Partners?			Positive Regulation Of Proteolysis Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Positive Regulation Of Catabolic Process Protein-containing Complex Organization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Intermediate-density Lipoprotein Particle Positive Regulation Of Inflammatory Response Regulation Of Cell Activation Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Regulation Of Proteolysis Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Cell Maturation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Protein Catabolic Process Protein-containing Complex Regulation Of Inflammatory Response Lipoprotein Particle Memory Growth Factor Receptor Binding Main Axon Notch Signaling Pathway Chromatin Binding Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Cellular Response To Metal Ion Low-density Lipoprotein Particle Mediated Signaling Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Nuclear Matrix RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Response To Vitamin B2 White Fat Cell Proliferation
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