UFL1 and TSC22D3

Number of citations of the paper that reports this interaction (PubMedID 32545848)
54

Data Source:
BioGRID (enzymatic study)

		UFL1	TSC22D3
Description		UFM1 specific ligase 1	TSC22 domain family member 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Cytoplasm Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Protein-containing Complex Site Of Double-strand Break Neuron Projection	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Transferase Activity Protein Kinase Binding UFM1 Ligase Activity UFM1 Transferase Activity	Protein Binding
	Biological Process	DNA Damage Checkpoint Signaling Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing Osteoblast Differentiation Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Repair DNA Damage Response Blood Circulation Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression Positive Regulation Of Autophagy Erythrocyte Differentiation DNA Damage Response, Signal Transduction By P53 Class Mediator SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Ribosome Disassembly Regulation Of Protein Localization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Endoplasmic Reticulum Stress Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process NLRP3 Inflammasome Complex Assembly Regulation Of Inflammatory Response Protein Stabilization Negative Regulation Of T Cell Activation Positive Regulation Of T Cell Activation Hematopoietic Stem Cell Differentiation Positive Regulation Of Glial Cell Proliferation Reticulophagy Protein Ufmylation Rescue Of Stalled Ribosome Antiviral Innate Immune Response Positive Regulation Of Reticulophagy Negative Regulation Of Signal Transduction By P53 Class Mediator Response To L-glutamate Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of IRE1-mediated Unfolded Protein Response Protein K69-linked Ufmylation	Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Negative Regulation Of Activation-induced Cell Death Of T Cells
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Stimuli-sensing channels
Drugs
Diseases
GWAS		Diastolic blood pressure ( 27841878) Headache ( 29397368) Language functional connectivity ( 34929384) Migraine ( 27322543) Migraine without aura ( 27322543) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Walking pace ( 33128006)
Interacting Genes		17 interacting genes: AHCY AKAP17A ATP4A ENY2 FGB H2AC4 HINFP IRAK1BP1 IRF3 MT1M PPIL1 PTPRO TIPRL TP53 TSC22D3 UFC1 ZNF219	15 interacting genes: BRME1 DCLK2 FOS HPCAL4 JUN MAD1L1 MTA2 NFKB1 NFKB2 PLEKHF2 RAF1 REL RELA SUMO1 UFL1
Entrez ID		23376	1831
HPRD ID		11109	04266
Ensembl ID		ENSG00000014123	ENSG00000157514
Uniprot IDs		O94874	Q99576
PDB IDs		8B9X 8C0D 8OHD 8OJ0 8OJ5 8OJ8 8QFC 8QFD
Enriched GO Terms of Interacting Partners?			Response To Muscle Stretch Non-canonical NF-kappaB Signal Transduction Positive Regulation Of MiRNA Metabolic Process Intracellular Signal Transduction Canonical NF-kappaB Signal Transduction Response To Mechanical Stimulus NF-kappaB P50/p65 Complex Regulation Of MiRNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Regulator Complex I-kappaB/NF-kappaB Complex Positive Regulation Of Transcription By RNA Polymerase II Intracellular Signaling Cassette NF-kappaB Complex Transcription Factor AP-1 Complex DNA-binding Transcription Factor Activity Positive Regulation Of MiRNA Transcription Chromatin Cellular Response To Nicotine Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Sequence-specific DNA Binding Regulation Of MiRNA Transcription Chromatin Binding Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process General Transcription Initiation Factor Binding Regulation Of Transcription By RNA Polymerase II Transcription Cis-regulatory Region Binding Actinin Binding Response To Peptide Response To Cytokine Cellular Response To Tumor Necrosis Factor Gland Development Cellular Response To Angiotensin Cellular Response To Interleukin-6 Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Nucleobase-containing Compound Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Response To Lipopolysaccharide Response To Interleukin-6 RNA Polymerase II Core Promoter Sequence-specific DNA Binding Response To Tumor Necrosis Factor Response To Molecule Of Bacterial Origin
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