IL12A and CD28

Number of citations: 56 (PubMedID 7516408)
Data Source: HPRD (in vitro, in vivo)

		IL12A	CD28
Name		interleukin 12A	CD28 molecule
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Late Endosome Lumen Interleukin-12 Complex	Immunological Synapse Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein Complex Involved In Cell Adhesion
	Molecular Function	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity	Protein Binding Coreceptor Activity Protein Kinase Binding Identical Protein Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Response To Virus Response To UV-B Cell Migration Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Type II Interferon Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Interleukin-12-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein T-helper 1 Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of Protein Secretion Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Extrinsic Apoptotic Signaling Pathway Cellular Response To Virus Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Negative Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Dendritic Cell Chemotaxis	Positive Regulation Of Cytokine Production Immune System Process Positive Regulation Of Inflammatory Response To Antigenic Stimulus Transcription By RNA Polymerase II Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-35 Signalling Interleukin-12 signaling Interleukin-12 signaling	PIP3 activates AKT signaling Nef mediated downregulation of CD28 cell surface expression Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
GWAS		Autoimmune traits (pleiotropy) ( 30572963 ) Behcet's disease ( 25799145 27548383 23291587 ) Bipolar disorder ( 31043756 ) Celiac disease ( 18311140 25920553 22057235 20190752 ) Limited cutaneous systemic scleroderma ( 24387989 ) Major depressive disorder ( 23377640 ) Multiple sclerosis ( 21833088 24076602 19525953 ) Primary biliary cholangitis ( 28425483 28062665 19458352 26394269 21399635 20639880 ) Primary biliary cirrhosis ( 22961000 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 26502338 27399966 28714469 ) Systemic sclerosis ( 24387989 31672989 )	Alopecia areata ( 25608926 ) Autoimmune traits (pleiotropy) ( 30572963 ) Celiac disease ( 22057235 20190752 25920553 ) Celiac disease and Rheumatoid arthritis ( 26546613 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Eosinophil count ( 32888494 ) Eosinophil percentage of white cells ( 32888494 ) Graves' disease ( 21841780 ) Heschl's gyrus morphology ( 25130324 ) Inflammatory bowel disease ( 26192919 ) Lymphocyte count ( 32888494 ) Multiple sclerosis ( 24076602 31604244 ) Primary biliary cholangitis ( 28425483 ) Primary sclerosing cholangitis ( 27992413 23603763 ) Rheumatoid arthritis ( 24390342 30423114 23143596 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Subcutaneous adipose tissue ( 29178545 ) Systemic lupus erythematosus ( 28714469 ) Ulcerative colitis ( 26192919 )
Novel Interactors		None recorded	8 novel interactors: AP1M1 BCS1L CAND1 CFLAR CTLA4 SEC14L2 WBP2NL YAP1
Interacting Genes		7 interacting genes: CD28 CXCL8 EBI3 IL12B S100A6 S100P WASF1	17 interacting genes: CD247 CD4 CD80 CD86 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC
Entrez ID		3592	940
HPRD ID		01193	01727
Ensembl ID		ENSG00000168811	ENSG00000178562
Uniprot IDs		O60595 P29459	B4E0L1 P10747
PDB IDs		1F45 3HMX 8XRP 8YI7	1YJD 3WA4 5AUL 5GJH 5GJI 6O8D 7PPN 7VU5 8S6Z 8W2V
GO Terms Enriched among Interactors		Positive Regulation Of Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of Alpha-beta T Cell Activation T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Lymphocyte Proliferation Regulation Of Alpha-beta T Cell Activation Mononuclear Cell Proliferation Leukocyte Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Leukocyte Proliferation Leukocyte Activation Regulation Of T Cell Proliferation Cell Activation Cytokine Activity Positive Regulation Of Interleukin-10 Production Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Humoral Immune Response Regulation Of Cell Population Proliferation Regulation Of Leukocyte Proliferation Regulation Of Mononuclear Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Cytokine Receptor Activity T Cell Activation Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Population Proliferation CD4-positive, Alpha-beta T Cell Activation Regulation Of Interleukin-10 Production Positive Regulation Of Immune System Process Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Type II Interferon Production Interleukin-12 Alpha Subunit Binding Regulation Of Viral Genome Replication Calcium-dependent Protein Binding Extracellular Region Regulation Of CD4-positive, Alpha-beta T Cell Activation Lymphocyte Activation Immune Response Positive Regulation Of Cell Adhesion Alpha-beta T Cell Activation Positive Regulation Of Gene Expression Regulation Of Cell-cell Adhesion Interleukin-8 Receptor Binding Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains	T Cell Activation Lymphocyte Activation Cell Activation Leukocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Mononuclear Cell Differentiation B Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Leukocyte Differentiation Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Differentiation Regulation Of T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of T Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Interleukin-2 Production Phosphatidylinositol 3-kinase Complex, Class IA Alpha-beta T Cell Activation Immune Response Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation T Cell Costimulation Immune Response-activating Signaling Pathway Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of Mononuclear Cell Proliferation Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Hemopoiesis Positive Regulation Of Metabolic Process Regulation Of Interleukin-2 Production Regulation Of Leukocyte Proliferation Intracellular Signal Transduction