IL12A and CD28

Number of citations of the paper that reports this interaction (PMID 7516408)
57

Data Source:
HPRD (in vivo, in vitro)

		IL12A	CD28
Gene Name		interleukin 12A	CD28 molecule
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Interleukin-12 Complex	Immunological Synapse Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity	Protease Binding SH3/SH2 Adaptor Activity Protein Binding Coreceptor Activity Identical Protein Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Cell Cycle Arrest Response To Virus Response To UV-B Cell Migration Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Defense Response To Protozoan Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Extrinsic Apoptotic Signaling Pathway	Positive Regulation Of Inflammatory Response To Antigenic Stimulus Humoral Immune Response Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process T Cell Costimulation Fc-epsilon Receptor Signaling Pathway Cytokine Biosynthetic Process Positive Regulation Of T Cell Proliferation Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Positive Regulation Of Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Proliferation Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Defense Response To Virus By Virus T Cell Receptor Signaling Pathway Positive Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease Costimulation by the CD28 family PIP3 activates AKT signaling HIV Infection Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PI3K events in ERBB2 signaling Downstream signaling of activated FGFR Innate Immune System Signaling by PDGF Signalling by NGF DAP12 interactions GAB1 signalosome Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Nef mediated downregulation of CD28 cell surface expression CD28 co-stimulation Host Interactions of HIV factors CD28 dependent PI3K/Akt signaling The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by ERBB4 Signaling by Overexpressed Wild-Type EGFR in Cancer Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling Signaling by FGFR CD28 dependent Vav1 pathway Signaling by ERBB2 Signaling by EGFR Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System
Drugs
Diseases
GWAS		Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140) Major depressive disorder ( 23377640) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 19458352 21399635 20639880)	Celiac disease ( 20190752) Graves' disease ( 21841780)
Protein-Protein Interactions		5 interactors: CD28 CXCL8 EBI3 IL12B WASF1	17 interactors: CD247 CD4 CD80 CD86 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC
Entrez ID		3592	940
HPRD ID		01193	01727
Ensembl ID		ENSG00000168811	ENSG00000178562
Uniprot IDs		E9PGR3 O60595 P29459	B4E0L1 P10747
PDB IDs		1F45 3HMX	1YJD
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of T Cell Proliferation Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Interferon-gamma Biosynthetic Process Regulation Of T Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cytokine Biosynthetic Process Positive Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion T-helper 1 Type Immune Response Cytokine Metabolic Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response Regulation Of Lymphocyte Activation Regulation Of Immune System Process Positive Regulation Of Interferon-gamma Production Cytokine-mediated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Cell Activation Leukocyte Activation Regulation Of Viral Genome Replication Regulation Of Cytokine Production Regulation Of Defense Response To Virus Regulation Of Interferon-gamma Production Cellular Response To Cytokine Stimulus Positive Regulation Of Inflammatory Response Cellular Response To Organic Substance Cell Activation Response To Cytokine Immune System Process Cytokine Production Regulation Of Protein Metabolic Process Cell Cycle Arrest Positive Regulation Of Adaptive Immune Response Positive Regulation Of Cell Proliferation Interferon-gamma Biosynthetic Process Cellular Response To Lipopolysaccharide T Cell Differentiation Regulation Of Viral Process Cellular Response To Molecule Of Bacterial Origin	Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Immune Response T Cell Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Regulation Of Immune Response Fc Receptor Signaling Pathway Positive Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of T Cell Activation Positive Regulation Of Cell Activation Defense Response Innate Immune Response Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Fc-epsilon Receptor Signaling Pathway Regulation Of Lymphocyte Activation Regulation Of Cell Adhesion Immune Response Regulation Of Immune System Process Regulation Of Cell Activation Immune System Process Phosphatidylinositol-mediated Signaling Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Phosphorylation Lymphocyte Activation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Cell Activation Regulation Of Phosphorus Metabolic Process T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Activation Leukocyte Aggregation Response To Stress Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Viral Process Positive Regulation Of Signal Transduction
Tagcloud ?		allelic dataset datasets discovery disequilibrium goldengate icc ifng ifngr1 ifngr2 ld lta ltb platform probands replicated rs10815144 rs12349785 rs2230724 rs3024971 shifts siblings snp snps stat6 tag taqman transmissions trios	accelerated allows augment b7 catalytically cd28re composite concert consistently converge costimulatory element herein ikappab ikk ikkalpha ikkbeta ikks inactive initiated interleukin liberated mitogen presenting proteasome robust tcr transactivation upstream
Tagcloud (Difference) ?		allelic dataset datasets discovery disequilibrium goldengate icc ifng ifngr1 ifngr2 ld lta ltb platform probands replicated rs10815144 rs12349785 rs2230724 rs3024971 shifts siblings snp snps stat6 tag taqman transmissions trios	accelerated allows augment b7 catalytically cd28re composite concert consistently converge costimulatory element herein ikappab ikk ikkalpha ikkbeta ikks inactive initiated interleukin liberated mitogen presenting proteasome robust tcr transactivation upstream
Tagcloud (Intersection) ?