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IL12A and WASF1
Number of citations of the paper that reports this interaction (PMID
16862120
)
85
Data Source:
HPRD
(in vitro)
IL12A
WASF1
Gene Name
interleukin 12A
WAS protein family, member 1
Image
Gene Ontology Annotations
Cellular Component
Extracellular Space
Cytoplasm
Interleukin-12 Complex
Cytoskeleton
Actin Cytoskeleton
Cell Junction
SCAR Complex
Synapse
Molecular Function
Cytokine Activity
Interleukin-12 Receptor Binding
Protein Binding
Growth Factor Activity
Interleukin-12 Beta Subunit Binding
Interleukin-27 Binding
Protein Heterodimerization Activity
Actin Binding
Protein Binding
Protein Complex Binding
Rac GTPase Binding
Biological Process
Positive Regulation Of T Cell Mediated Cytotoxicity
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Immune Response
Cell Cycle Arrest
Response To Virus
Response To UV-B
Cell Migration
Response To Lipopolysaccharide
Negative Regulation Of Interleukin-17 Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Natural Killer Cell Activation
Positive Regulation Of Mononuclear Cell Proliferation
Positive Regulation Of Smooth Muscle Cell Apoptotic Process
Positive Regulation Of T Cell Proliferation
Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein
Defense Response To Protozoan
Positive Regulation Of T Cell Differentiation
Positive Regulation Of Cell Adhesion
Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity
Negative Regulation Of Smooth Muscle Cell Proliferation
Positive Regulation Of Lymphocyte Proliferation
Defense Response To Gram-positive Bacterium
Positive Regulation Of NK T Cell Activation
Extrinsic Apoptotic Signaling Pathway
Protein Complex Assembly
Movement Of Cell Or Subcellular Component
Rac Protein Signal Transduction
Actin Filament Polymerization
Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways
Signaling by VEGF
Fcgamma receptor (FCGR) dependent phagocytosis
VEGFA-VEGFR2 Pathway
Regulation of actin dynamics for phagocytic cup formation
Innate Immune System
Drugs
Diseases
GWAS
Behcet's disease (
23291587
)
Celiac disease (
20190752
18311140
)
Major depressive disorder (
23377640
)
Multiple sclerosis (
19525953
21833088
)
Primary biliary cirrhosis (
19458352
21399635
20639880
)
Protein-Protein Interactions
5 interactors:
CD28
CXCL8
EBI3
IL12B
WASF1
28 interactors:
ABI1
ABL1
ACTB
ACTG1
ACTR2
BAD
BAIAP2
BRK1
CDC42
CDK5
CRK
CXCL8
CYFIP2
DNMBP
FYN
GNAI1
GRB2
IFT20
IL12A
NCK1
NCKAP1
PFN1
PRKAR2A
PSTPIP1
RAC1
SORBS2
SRGAP3
TRIP10
Entrez ID
3592
8936
HPRD ID
01193
05434
Ensembl ID
ENSG00000168811
ENSG00000112290
Uniprot IDs
E9PGR3
O60595
P29459
Q92558
PDB IDs
1F45
3HMX
3P8C
Enriched GO Terms of Interacting Partners
?
Positive Regulation Of Alpha-beta T Cell Proliferation
Positive Regulation Of Cytokine Biosynthetic Process
Positive Regulation Of T Cell Proliferation
Regulation Of Cytokine Biosynthetic Process
Positive Regulation Of Lymphocyte Proliferation
Positive Regulation Of Mononuclear Cell Proliferation
Positive Regulation Of Interferon-gamma Biosynthetic Process
Regulation Of T Cell Proliferation
Regulation Of Cell Adhesion
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Cytokine Biosynthetic Process
Positive Regulation Of Immune System Process
Positive Regulation Of Cell-cell Adhesion
T-helper 1 Type Immune Response
Cytokine Metabolic Process
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Positive Regulation Of Cytokine Production
Positive Regulation Of Protein Metabolic Process
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Immune Response
Regulation Of Lymphocyte Activation
Regulation Of Immune System Process
Positive Regulation Of Interferon-gamma Production
Cytokine-mediated Signaling Pathway
Regulation Of Cell Proliferation
Regulation Of Cell Activation
Leukocyte Activation
Regulation Of Viral Genome Replication
Regulation Of Cytokine Production
Regulation Of Defense Response To Virus
Regulation Of Interferon-gamma Production
Cellular Response To Cytokine Stimulus
Positive Regulation Of Inflammatory Response
Cellular Response To Organic Substance
Cell Activation
Response To Cytokine
Immune System Process
Cytokine Production
Regulation Of Protein Metabolic Process
Cell Cycle Arrest
Positive Regulation Of Adaptive Immune Response
Positive Regulation Of Cell Proliferation
Interferon-gamma Biosynthetic Process
Cellular Response To Lipopolysaccharide
T Cell Differentiation
Regulation Of Viral Process
Cellular Response To Molecule Of Bacterial Origin
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc-gamma Receptor Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc Receptor Signaling Pathway
Endocytosis
Phagocytosis
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-activating Cell Surface Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Vesicle-mediated Transport
Innate Immune Response
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Immune Response
Defense Response
Positive Regulation Of Immune System Process
Positive Regulation Of Immune Response
Regulation Of Immune Response
Enzyme Linked Receptor Protein Signaling Pathway
Regulation Of Immune System Process
Actin Cytoskeleton Organization
Actin Filament-based Process
Immune System Process
Response To Stress
Signaling
Blood Coagulation
Cell Communication
Hemostasis
Movement Of Cell Or Subcellular Component
Signal Transduction
Regulation Of Actin Cytoskeleton Organization
Regulation Of Cytoskeleton Organization
Cell Surface Receptor Signaling Pathway
Regulation Of Organelle Organization
Regulation Of Actin Filament-based Process
Transport
Cellular Response To Stimulus
Regulation Of Body Fluid Levels
Locomotion
Wound Healing
Cell Projection Morphogenesis
Cell Part Morphogenesis
Cytoskeleton Organization
Cell Projection Organization
Response To Stimulus
Response To Wounding
Axonogenesis
Axon Guidance
Ephrin Receptor Signaling Pathway
Axon Development
Tagcloud
?
allelic
dataset
datasets
discovery
disequilibrium
goldengate
icc
ifng
ifngr1
ifngr2
ld
lta
ltb
platform
probands
replicated
rs10815144
rs12349785
rs2230724
rs3024971
shifts
siblings
snp
snps
stat6
tag
taqman
transmissions
trios
Tagcloud (Difference)
?
allelic
dataset
datasets
discovery
disequilibrium
goldengate
icc
ifng
ifngr1
ifngr2
ld
lta
ltb
platform
probands
replicated
rs10815144
rs12349785
rs2230724
rs3024971
shifts
siblings
snp
snps
stat6
tag
taqman
transmissions
trios
Tagcloud (Intersection)
?