CD28 and SEC14L2

		CD28	SEC14L2
Description		CD28 molecule	SEC14 like lipid binding 2
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GO Annotations	Cellular Component	Immunological Synapse Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Protein Complex Involved In Cell Adhesion	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Coreceptor Activity Protein Kinase Binding Identical Protein Binding	Phospholipid Binding Lipid Binding Vitamin E Binding
	Biological Process	Positive Regulation Of Cytokine Production Immune System Process Positive Regulation Of Inflammatory Response To Antigenic Stimulus Transcription By RNA Polymerase II Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression T Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-4 Production CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation Positive Regulation Of T Cell Proliferation T Cell Activation Regulation Of T Cell Proliferation Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Thymic T Cell Selection Regulatory T Cell Differentiation Positive Regulation Of Viral Genome Replication Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Isotype Switching To IgG Isotypes T Cell Receptor Signaling Pathway Positive Regulation Of T Cell Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Apoptotic Signaling Pathway Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of DNA-templated Transcription
Pathways		PIP3 activates AKT signaling Nef mediated downregulation of CD28 cell surface expression Constitutive Signaling by Aberrant PI3K in Cancer Co-stimulation by CD28 CD28 dependent PI3K/Akt signaling CD28 dependent Vav1 pathway PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Drugs			Vitamin E alpha-Tocopherol succinate D-alpha-Tocopherol acetate
Diseases
GWAS		Alopecia areata ( 25608926) Autoimmune traits (pleiotropy) ( 30572963) Celiac disease ( 22057235 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Graves' disease ( 21841780) Heschl's gyrus morphology ( 25130324) Inflammatory bowel disease ( 26192919) Lymphocyte count ( 32888494) Multiple sclerosis ( 24076602 31604244) Primary biliary cholangitis ( 28425483) Primary sclerosing cholangitis ( 27992413 23603763) Rheumatoid arthritis ( 24390342 30423114 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 26192919)	Breast size ( 22747683) Plateletcrit ( 27863252)
Interacting Genes		17 interacting genes: CD247 CD4 CD80 CD86 DUSP14 GRAP2 GRB2 IL12A ITK LCK LRRC23 NSF PIK3CG PIK3R1 PIK3R2 PLCG1 PTPRC	1 interacting genes: PIK3CG
Entrez ID		940	23541
HPRD ID		01727	06344
Ensembl ID		ENSG00000178562	ENSG00000100003
Uniprot IDs		B4E0L1 P10747	B7Z3Z8 O76054
PDB IDs		1YJD 3WA4 5AUL 5GJH 5GJI 6O8D 7PPN 7VU5 8S6Z 8W2V	1O6U 1OLM 4OMJ 4OMK
Enriched GO Terms of Interacting Partners?		T Cell Activation Lymphocyte Activation Cell Activation Leukocyte Activation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway T Cell Differentiation Regulation Of Immune Response Positive Regulation Of Immune System Process Regulation Of Cell Adhesion Phosphotyrosine Residue Binding Cell Surface Receptor Signaling Pathway T Cell Receptor Signaling Pathway Mononuclear Cell Differentiation B Cell Receptor Signaling Pathway Gamma-delta T Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Immune System Process Leukocyte Differentiation Regulation Of Leukocyte Cell-cell Adhesion Lymphocyte Differentiation Regulation Of T Cell Activation Neurotrophin TRKA Receptor Binding Positive Regulation Of T Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Interleukin-2 Production Phosphatidylinositol 3-kinase Complex, Class IA Alpha-beta T Cell Activation Immune Response Positive Regulation Of Cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cytokine Production Regulation Of Lymphocyte Activation T Cell Costimulation Immune Response-activating Signaling Pathway Regulation Of Immune System Process Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Multicellular Organismal Process Regulation Of Mononuclear Cell Proliferation Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Hemopoiesis Positive Regulation Of Metabolic Process Regulation Of Interleukin-2 Production Regulation Of Leukocyte Proliferation Intracellular Signal Transduction	Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Lymphocyte Proliferation T Cell Proliferation Mononuclear Cell Proliferation Leukocyte Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T Cell Activation Natural Killer Cell Chemotaxis Positive Regulation Of Cytokine Production Protein Complex Involved In Cell Adhesion Leukocyte Activation Regulation Of Inflammatory Response Regulatory T Cell Differentiation Lymphocyte Activation CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of Defense Response 1-phosphatidylinositol-3-kinase Activity Negative Regulation Of Cardiac Muscle Contraction Phosphatidylinositol 3-kinase Complex, Class IB Negative Regulation Of Striated Muscle Contraction Respiratory Burst Involved In Defense Response Phosphatidylinositol 3-kinase Complex Negative Regulation Of Triglyceride Catabolic Process 1-phosphatidylinositol-4-phosphate 3-kinase Activity Negative Regulation Of Fibroblast Apoptotic Process Phosphatidylinositol 3-kinase Complex, Class IA 1-phosphatidylinositol-4,5-bisphosphate 3-kinase Activity Neutrophil Extravasation Positive Regulation Of Isotype Switching To IgG Isotypes Positive Regulation Of Protein Metabolic Process Regulation Of Cytokine Production Regulation Of Defense Response Regulation Of Cell Adhesion Thymic T Cell Selection Intracellular Signaling Cassette Cell Activation Alpha-beta T Cell Proliferation Negative Regulation Of Apoptotic Process Negative Thymic T Cell Selection Positive Regulation Of Inflammatory Response To Antigenic Stimulus Negative T Cell Selection Regulation Of Isotype Switching To IgG Isotypes Cell Population Proliferation Hepatocyte Apoptotic Process Regulation Of Fibroblast Apoptotic Process Secretory Granule Localization Positive Regulation Of Rac Protein Signal Transduction
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