IL12A and CXCL8

Number of citations of the paper that reports this interaction (PMID 16862120)
85

Data Source:
HPRD (in vitro)

		IL12A	CXCL8
Gene Name		interleukin 12A	chemokine (C-X-C motif) ligand 8
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Interleukin-12 Complex	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity	Interleukin-8 Receptor Binding Protein Binding Chemokine Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Cell Cycle Arrest Response To Virus Response To UV-B Cell Migration Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Defense Response To Protozoan Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Extrinsic Apoptotic Signaling Pathway	Angiogenesis Response To Molecule Of Bacterial Origin Movement Of Cell Or Subcellular Component Chemotaxis Inflammatory Response Immune Response Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cell Cycle Arrest Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Calcium-mediated Signaling Regulation Of Cell Adhesion Neutrophil Chemotaxis Endoplasmic Reticulum Unfolded Protein Response Receptor Internalization Response To Endoplasmic Reticulum Stress Intracellular Signal Transduction Neutrophil Activation Cellular Protein Metabolic Process Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Embryonic Digestive Tract Development Induction Of Positive Chemotaxis Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Positive Regulation Of Neutrophil Chemotaxis
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Cellular Senescence ATF4 activates genes Senescence-Associated Secretory Phenotype (SASP) GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling Peptide ligand-binding receptors Chemokine receptors bind chemokines G alpha (i) signalling events PERK regulates gene expression Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140) Major depressive disorder ( 23377640) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 19458352 21399635 20639880)
Protein-Protein Interactions		5 interactors: CD28 CXCL8 EBI3 IL12B WASF1	18 interactors: ACKR1 ARFGAP3 BAG6 CCL4 CCL5 CSNK2A1 CTSL CXCR1 CXCR2 EP300 GNAI2 IL12A MMP9 PF4 POMGNT1 SDC1 SGTA WASF1
Entrez ID		3592	3576
HPRD ID		01193	00909
Ensembl ID		ENSG00000168811	ENSG00000169429
Uniprot IDs		E9PGR3 O60595 P29459	P10145
PDB IDs		1F45 3HMX	1ICW 1IKL 1IKM 1IL8 1ILP 1ILQ 1QE6 1ROD 2IL8 3IL8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of T Cell Proliferation Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Interferon-gamma Biosynthetic Process Regulation Of T Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cytokine Biosynthetic Process Positive Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion T-helper 1 Type Immune Response Cytokine Metabolic Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response Regulation Of Lymphocyte Activation Regulation Of Immune System Process Positive Regulation Of Interferon-gamma Production Cytokine-mediated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Cell Activation Leukocyte Activation Regulation Of Viral Genome Replication Regulation Of Cytokine Production Regulation Of Defense Response To Virus Regulation Of Interferon-gamma Production Cellular Response To Cytokine Stimulus Positive Regulation Of Inflammatory Response Cellular Response To Organic Substance Cell Activation Response To Cytokine Immune System Process Cytokine Production Regulation Of Protein Metabolic Process Cell Cycle Arrest Positive Regulation Of Adaptive Immune Response Positive Regulation Of Cell Proliferation Interferon-gamma Biosynthetic Process Cellular Response To Lipopolysaccharide T Cell Differentiation Regulation Of Viral Process Cellular Response To Molecule Of Bacterial Origin	Chemokine-mediated Signaling Pathway Defense Response Inflammatory Response Signal Transduction Cell Chemotaxis Dendritic Cell Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Chemotaxis Signaling Response To External Stimulus Cell Communication Movement Of Cell Or Subcellular Component Positive Regulation Of Leukocyte Migration Leukocyte Migration Interleukin-8-mediated Signaling Pathway Response To Stress Immune System Process Dendritic Cell Migration Leukocyte Chemotaxis Positive Regulation Of Chemotaxis Regulation Of Leukocyte Migration Cell Migration Cellular Response To Stimulus Locomotion Interaction With Symbiont Positive Regulation Of Behavior Cell Motility Cell Surface Receptor Signaling Pathway Regulation Of Chemotaxis Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Natural Killer Cell Chemotaxis Regulation Of Behavior Cytokine-mediated Signaling Pathway Regulation Of Viral Transcription Immune Response Response To Stimulus Negative Regulation By Host Of Viral Transcription Response To Organic Substance Positive Regulation Of Immune System Process Regulation Of Apoptotic Process Cellular Response To Cytokine Stimulus Regulation Of Cell Migration Regulation Of Cell Proliferation Negative Regulation Of Myeloid Cell Apoptotic Process Regulation Of Cell Death Regulation Of Cell Motility Regulation Of Locomotion
Tagcloud ?		allelic dataset datasets discovery disequilibrium goldengate icc ifng ifngr1 ifngr2 ld lta ltb platform probands replicated rs10815144 rs12349785 rs2230724 rs3024971 shifts siblings snp snps stat6 tag taqman transmissions trios
Tagcloud (Difference) ?		allelic dataset datasets discovery disequilibrium goldengate icc ifng ifngr1 ifngr2 ld lta ltb platform probands replicated rs10815144 rs12349785 rs2230724 rs3024971 shifts siblings snp snps stat6 tag taqman transmissions trios
Tagcloud (Intersection) ?