IL12A and EBI3

Number of citations of the paper that reports this interaction (PMID 934235)
0

Data Source:
HPRD (in vivo)

		IL12A	EBI3
Gene Name		interleukin 12A	Epstein-Barr virus induced 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytoplasm Interleukin-12 Complex	Extracellular Space Plasma Membrane
	Molecular Function	Cytokine Activity Interleukin-12 Receptor Binding Protein Binding Growth Factor Activity Interleukin-12 Beta Subunit Binding Interleukin-27 Binding Protein Heterodimerization Activity	Cytokine Receptor Activity Cytokine Activity Protein Binding Interleukin-27 Receptor Binding
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Immune Response Cell Cycle Arrest Response To Virus Response To UV-B Cell Migration Response To Lipopolysaccharide Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Natural Killer Cell Activation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Defense Response To Protozoan Positive Regulation Of T Cell Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Defense Response To Gram-positive Bacterium Positive Regulation Of NK T Cell Activation Extrinsic Apoptotic Signaling Pathway	Humoral Immune Response Cytokine-mediated Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of Interferon-gamma Biosynthetic Process Positive Regulation Of Alpha-beta T Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Behcet's disease ( 23291587) Celiac disease ( 20190752 18311140) Major depressive disorder ( 23377640) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 19458352 21399635 20639880)
Protein-Protein Interactions		5 interactors: CD28 CXCL8 EBI3 IL12B WASF1	6 interactors: CANX GOSR1 IL12A IL27RA MDFI SMAD3
Entrez ID		3592	10148
HPRD ID		01193	12051
Ensembl ID		ENSG00000168811	ENSG00000105246
Uniprot IDs		E9PGR3 O60595 P29459	Q14213
PDB IDs		1F45 3HMX
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Cytokine Biosynthetic Process Positive Regulation Of T Cell Proliferation Regulation Of Cytokine Biosynthetic Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Interferon-gamma Biosynthetic Process Regulation Of T Cell Proliferation Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Cytokine Biosynthetic Process Positive Regulation Of Immune System Process Positive Regulation Of Cell-cell Adhesion T-helper 1 Type Immune Response Cytokine Metabolic Process Regulation Of T Cell Activation Positive Regulation Of Cell Activation Positive Regulation Of Cytokine Production Positive Regulation Of Protein Metabolic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Immune Response Regulation Of Lymphocyte Activation Regulation Of Immune System Process Positive Regulation Of Interferon-gamma Production Cytokine-mediated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Cell Activation Leukocyte Activation Regulation Of Viral Genome Replication Regulation Of Cytokine Production Regulation Of Defense Response To Virus Regulation Of Interferon-gamma Production Cellular Response To Cytokine Stimulus Positive Regulation Of Inflammatory Response Cellular Response To Organic Substance Cell Activation Response To Cytokine Immune System Process Cytokine Production Regulation Of Protein Metabolic Process Cell Cycle Arrest Positive Regulation Of Adaptive Immune Response Positive Regulation Of Cell Proliferation Interferon-gamma Biosynthetic Process Cellular Response To Lipopolysaccharide T Cell Differentiation Regulation Of Viral Process Cellular Response To Molecule Of Bacterial Origin	Positive Regulation Of Cytokine Production Positive Regulation Of Interferon-gamma Production Defense Response To Gram-positive Bacterium Regulation Of Interferon-gamma Production Regulation Of Transcription Factor Import Into Nucleus Regulation Of Cytokine Production Positive Regulation Of Transforming Growth Factor Beta3 Production Extrinsic Apoptotic Signaling Pathway Embryonic Skeletal System Morphogenesis Interleukin-27-mediated Signaling Pathway Response To Other Organism Cell Cycle Arrest Response To Biotic Stimulus Positive Regulation Of Adaptive Immune Response Embryonic Skeletal System Development Evasion Or Tolerance Of Host Defenses By Virus Regulation Of Protein Import Into Nucleus Immune System Process Regulation Of Immune Response Defense Response To Bacterium Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Positive Regulation Of Extracellular Matrix Assembly Positive Regulation Of Tyrosine Phosphorylation Of Stat4 Protein Regulation Of Adaptive Immune Response Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Regulation Of Extracellular Matrix Assembly Positive Regulation Of NK T Cell Activation Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Primary MiRNA Processing Regulation Of Protein Phosphorylation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Regulation Of Binding Regulation Of Intracellular Protein Transport Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Osteoblast Proliferation SMAD Protein Complex Assembly Skeletal System Morphogenesis Positive Regulation Of Immune Response To Tumor Cell Regulation Of Transforming Growth Factor Beta2 Production Transdifferentiation Regulation Of Isotype Switching To IgG Isotypes Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Catenin Import Into Nucleus Embryonic Organ Morphogenesis Positive Regulation Of Signal Transduction Negative Regulation Of Interleukin-17 Production Positive Regulation Of Alkaline Phosphatase Activity
Tagcloud ?		allelic dataset datasets discovery disequilibrium goldengate icc ifng ifngr1 ifngr2 ld lta ltb platform probands replicated rs10815144 rs12349785 rs2230724 rs3024971 shifts siblings snp snps stat6 tag taqman transmissions trios	c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining foxp3 helios herein neuropilin nodes nrp1 pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger
Tagcloud (Difference) ?		allelic dataset datasets discovery disequilibrium goldengate icc ifng ifngr1 ifngr2 ld lta ltb platform probands replicated rs10815144 rs12349785 rs2230724 rs3024971 shifts siblings snp snps stat6 tag taqman transmissions trios	c57bl cd25 cd28 cd3 cd4 cd8 ctla cytometry distinguishing draining foxp3 helios herein neuropilin nodes nrp1 pdlns peripherally proportion ptreg reliable seems spleen stimulating thymic thymus treg ttreg younger
Tagcloud (Intersection) ?