TM9SF2 and RAB9A

Number of citations: 39 (PubMedID 9230071)
Data Source: HPRD (two hybrid, in vitro)

		TM9SF2	RAB9A
Name		transmembrane 9 superfamily member 2	RAB9A, member RAS oncogene family
Structure		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Golgi Apparatus Microtubule Organizing Center Cytoskeleton Plasma Membrane Endosome Membrane Membrane Extracellular Exosome	Golgi Membrane Lysosome Endosome Late Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane Transport Vesicle Cytoplasmic Vesicle Membrane Phagocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane Melanosome Phagocytic Vesicle Extracellular Exosome
	Molecular Function	None	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding Identical Protein Binding
	Biological Process	Ceramide Metabolic Process Glycosphingolipid Biosynthetic Process Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Protein Localization To Membrane	Receptor-mediated Endocytosis Protein Transport Rab Protein Signal Transduction Regulation Of Protein Localization Retrograde Transport, Endosome To Golgi Positive Regulation Of Exocytosis
Pathways		None	Retrograde transport at the Trans-Golgi-Network RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs RHOBTB3 ATPase cycle
Drugs		None	Guanosine-5'-Diphosphate
GWAS		Asthma ( 30929738 31619474 32296059 34103634 ) Asthma (adult onset) ( 30929738 ) Asthma (childhood onset) ( 31036433 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Periodontal disease-related phenotype (Socransky) ( 26962152 )	Red cell distribution width ( 32888494 )
Interacting Genes		4 interacting genes: AQP2 HTR2C RAB9A SMAD4	8 interacting genes: BCL3 GDI1 GDI2 PLIN3 RABEPK RHOBTB3 TM9SF2 TRIM14
Entrez ID		9375	9367
HPRD ID		09198	02236
Ensembl ID		ENSG00000125304	ENSG00000123595
Uniprot IDs		A0A024QYR8 Q99805	P51151
PDB IDs		Not available	1WMS 7E1T
GO Terms Enriched among Interactors		Lumenal Side Of Membrane Cellular Response To Mercury Ion Cellular Response To Water Deprivation Cytoplasmic Vesicle Membrane Chemical Homeostasis Glycerol Transmembrane Transporter Activity Gq/11-coupled Serotonin Receptor Activity Positive Regulation Of Phosphatidylinositol Biosynthetic Process 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine Binding Intracellular Signaling Cassette Regulation Of Secretion Regulation Of Secretion By Cell Activin Responsive Factor Complex Left Ventricular Cardiac Muscle Tissue Morphogenesis Gonad Morphogenesis Negative Regulation Of Cardiac Myofibril Assembly Nephrogenic Mesenchyme Morphogenesis Metanephric Mesenchyme Morphogenesis Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Female Gonad Morphogenesis Renal Water Transport Response To Water Deprivation Glycerol Transmembrane Transport Water Transmembrane Transporter Activity Tube Development Homeostatic Process Regulation Of Hormone Secretion Regulation Of ERK1 And ERK2 Cascade G Protein-coupled Serotonin Receptor Complex Phospholipase C-activating Serotonin Receptor Signaling Pathway Regulation Of Corticotropin-releasing Hormone Secretion SMAD Protein Complex Positive Regulation Of Luteinizing Hormone Secretion Regulation Of Follicle-stimulating Hormone Secretion Positive Regulation Of Follicle-stimulating Hormone Secretion Atrioventricular Valve Formation Sebaceous Gland Development Heteromeric SMAD Protein Complex Formation Of Anatomical Boundary Positive Regulation Of Secretion By Cell Brainstem Development Mesendoderm Development Sulfate Binding Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Transforming Growth Factor Beta2 Production Endocardial Cell Differentiation Polyol Transmembrane Transport Metanephric Collecting Duct Development Response To Mercury Ion Serotonin Binding	Rab GDP-dissociation Inhibitor Activity GDP-dissociation Inhibitor Activity Vesicle-mediated Transport Golgi Apparatus Small GTPase Binding Endosome Membrane Bcl3-Bcl10 Complex Bcl3/NF-kappaB2 Complex Cytoplasm Follicular Dendritic Cell Differentiation Transport Vesicle Trans-Golgi Network Membrane Follicular Dendritic Cell Activation Negative Regulation Of Protein Localization To Cilium Positive Regulation Of Triglyceride Storage Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process