GPX8 and MARCHF5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPX8	MARCHF5
Description		glutathione peroxidase 8 (putative)	membrane associated ring-CH-type finger 5
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Membrane	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding GTPase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Oxidant Detoxification	Protein Polyubiquitination Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein Ubiquitination Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Protein K27-linked Ubiquitination NLRP3 Inflammasome Complex Assembly Protein Autoubiquitination Protein K63-linked Ubiquitination Protein Localization To Mitochondrion Protein K48-linked Ubiquitination Regulation Of Mitochondrial Fission Positive Regulation Of Mitochondrial Fission CGAS/STING Signaling Pathway Positive Regulation Of CGAS/STING Signaling Pathway Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Pathways		Detoxification of Reactive Oxygen Species
Drugs		Glutathione Glutathione disulfide Benzoyl peroxide
Diseases
GWAS		Cocaine dependence ( 31212010)
Interacting Genes		170 interacting genes: AGTRAP AIG1 ALG8 ANKRD46 APOC3 APOD AQP1 AQP2 AQP3 ARLN ASGR1 ASPH BCL2L2 BET1 BIK BMP10 BNIP2 BTN2A2 C14orf180 C1GALT1 C3orf52 CACNG1 CCDC167 CD302 CD53 CD81 CDIPT CDS2 CFHR5 CHST1 CLDN19 CLDND2 CLEC1A CLEC2A CMTM5 CNIH1 CNIH3 COL4A5 COL8A2 CORIN CXCL16 CYB561 CYB561A3 CYB561D2 CYBC1 DNAJC30 DOLK EDDM3B ERG28 ERO1A FA2H FAM3C FAXDC2 GET3 GIMAP1 GOSR2 GPR151 GPR37L1 GRINA GYPA HHATL HMOX2 IGFBP5 INSIG2 ITGAM KIR2DL3 KLRG1 LAPTM4B LEPROTL1 LHFPL5 LNPEP LPAR3 MAN2B2 MARCHF2 MARCHF5 MFSD6 MGST2 MGST3 MIP MMD MYADML2 NEU1 NINJ1 NINJ2 NIPAL3 NKG7 NRM OCLN PAEP PAQR5 PAQR6 PGAP2 PLLP PLN PLP2 PLPP4 PLPP6 PMP22 PNLIPRP1 PRB1 RBFA RND1 RPRM RTP2 SCARB2 SCARF1 SCD SEC22B SELENOK SERINC1 SERINC2 SERP1 SERTM1 SFTPC SGMS2 SLC13A3 SLC30A3 SLC34A3 SLC35A1 SLC35B4 SLC38A7 SLC41A2 SLC61A1 SMAGP SNORC ST6GAL2 STX3 STX8 SYT15 SYT15B TF THBD TIMMDC1 TM4SF4 TMBIM6 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM14B TMEM14C TMEM19 TMEM203 TMEM218 TMEM229B TMEM243 TMEM254 TMEM42 TMEM50B TMEM60 TMEM86A TMEM86B TMEM97 TMPRSS4 TMUB2 TRAM1L1 TSPAN33 TSPO2 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VKORC1L1 VSTM1 VTI1B YIF1A YIPF6 ZDHHC22	43 interacting genes: AKTIP ANKS6 AQP6 BIK BNIP1 CGRRF1 CREB3 ERGIC3 FATE1 FIS1 FUNDC1 GPX8 HSD17B13 IMMT MANBAL MAP1B MFN2 ODF4 POLG POLG2 PTPN5 RECQL4 RTN4IP1 SAR1A SCD SGPL1 SOD1 STMN4 TANK TIMMDC1 TMEM139 TMEM14B UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E3 UBE2I UBE2N UBE2T UBE2W UTRN YIF1A
Entrez ID		493869	54708
HPRD ID		17416	07909
Ensembl ID		ENSG00000164294	ENSG00000198060
Uniprot IDs		B4DPY0 E7ETY7 J3KNB5 Q8TED1	Q9NX47
PDB IDs		3CYN 3KIJ
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Plasma Membrane SNAP Receptor Activity SNARE Complex Golgi Membrane Cholesterol Binding Water Channel Activity Glycerol Transmembrane Transport Transmembrane Transport Channel Activity Renal Water Transport Polyol Transmembrane Transport Glycerol Transmembrane Transporter Activity Vesicle-mediated Transport Lysosomal Membrane Presynaptic Endosome Membrane Alkenylglycerophosphocholine Hydrolase Activity Water Transport Golgi Apparatus Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Lipid Metabolic Process Cellular Response To Mercury Ion Ascorbate Homeostasis ER To Golgi Transport Vesicle Membrane Endomembrane System Lysosome Organelle Fusion Fluid Transport Vesicle Fusion SNARE Binding Carbohydrate Binding Transmembrane Monodehydroascorbate Reductase Activity Membrane Destabilizing Activity Compact Myelin Transmembrane Ascorbate Ferrireductase Activity Respiratory Burst After Phagocytosis Organelle Membrane Fusion Monoatomic Ion Transport Sterol Biosynthetic Process Renal Water Homeostasis Metal Ion Transport Negative Regulation Of Lipoprotein Metabolic Process Water Transmembrane Transporter Activity Late Endosome Membrane Leukotriene-C4 Synthase Activity Membrane Fusion	Ubiquitin Conjugating Enzyme Activity Protein Monoubiquitination Protein Polyubiquitination Ubiquitin-protein Transferase Activity Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Modification By Small Protein Conjugation Mitochondrial Outer Membrane Cellular Response To Stress Gamma DNA Polymerase Complex Protein Ubiquitination Response To Nutrient Levels Negative Regulation Of TORC1 Signaling Protein Binding Post-translational Protein Modification Protein K63-linked Ubiquitination Mitochondrion Organization Negative Regulation Of TOR Signaling Regulation Of TORC1 Signaling Ubiquitin Protein Ligase Binding Nucleotide Binding DNA Repair Apoptotic Process Mitochondrial DNA Replication Mitochondrion Cell Death Programmed Cell Death DNA Metabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Protein-containing Complex Regulation Of TOR Signaling TORC1 Signaling DNA Damage Response Protein Autoubiquitination Endoplasmic Reticulum Membrane Endoplasmic Reticulum Response To Stress Mitochondrial DNA Metabolic Process Positive Regulation Of Protein Polyubiquitination Mitochondrial Fusion Ubiquitin-like Protein Transferase Activity Mitochondrial Membrane TOR Signaling DNA-directed DNA Polymerase Activity Proteolysis Involved In Protein Catabolic Process Mitochondrial Calcium Ion Homeostasis Protein Modification Process ATP Binding Protein K6-linked Ubiquitination
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