GPX8 and INSIG2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		GPX8	INSIG2
Description		glutathione peroxidase 8 (putative)	insulin induced gene 2
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Lumen Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane SREBP-SCAP-Insig Complex
	Molecular Function	Peroxidase Activity Glutathione Peroxidase Activity Protein Binding Oxidoreductase Activity	Protein Binding Oxysterol Binding Lipid Binding Protein Sequestering Activity
	Biological Process	Response To Oxidative Stress Cellular Response To Oxidative Stress Cellular Oxidant Detoxification	NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Triglyceride Metabolic Process Cholesterol Biosynthetic Process Response To Sterol Depletion Steroid Metabolic Process Cholesterol Metabolic Process Negative Regulation Of Steroid Biosynthetic Process Sterol Biosynthetic Process Response To Insulin Cellular Response To Insulin Stimulus SREBP Signaling Pathway Response To Lipid SREBP-SCAP Complex Retention In Endoplasmic Reticulum Inner Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Cholesterol Biosynthetic Process Negative Regulation Of Fatty Acid Biosynthetic Process Protein Maturation Roof Of Mouth Development Cranial Suture Morphogenesis Response To Fatty Acid
Pathways		Detoxification of Reactive Oxygen Species	Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs		Glutathione Glutathione disulfide Benzoyl peroxide
Diseases
GWAS		Cocaine dependence ( 31212010)	Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 30275531 24097068) LDL cholesterol levels ( 30698716 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731 33339817) Lumbar spine bone mineral density ( 22504420) Monobrow ( 27182965) Mosquito bite size ( 28199695) Total cholesterol levels ( 30275531)
Interacting Genes		170 interacting genes: AGTRAP AIG1 ALG8 ANKRD46 APOC3 APOD AQP1 AQP2 AQP3 ARLN ASGR1 ASPH BCL2L2 BET1 BIK BMP10 BNIP2 BTN2A2 C14orf180 C1GALT1 C3orf52 CACNG1 CCDC167 CD302 CD53 CD81 CDIPT CDS2 CFHR5 CHST1 CLDN19 CLDND2 CLEC1A CLEC2A CMTM5 CNIH1 CNIH3 COL4A5 COL8A2 CORIN CXCL16 CYB561 CYB561A3 CYB561D2 CYBC1 DNAJC30 DOLK EDDM3B ERG28 ERO1A FA2H FAM3C FAXDC2 GET3 GIMAP1 GOSR2 GPR151 GPR37L1 GRINA GYPA HHATL HMOX2 IGFBP5 INSIG2 ITGAM KIR2DL3 KLRG1 LAPTM4B LEPROTL1 LHFPL5 LNPEP LPAR3 MAN2B2 MARCHF2 MARCHF5 MFSD6 MGST2 MGST3 MIP MMD MYADML2 NEU1 NINJ1 NINJ2 NIPAL3 NKG7 NRM OCLN PAEP PAQR5 PAQR6 PGAP2 PLLP PLN PLP2 PLPP4 PLPP6 PMP22 PNLIPRP1 PRB1 RBFA RND1 RPRM RTP2 SCARB2 SCARF1 SCD SEC22B SELENOK SERINC1 SERINC2 SERP1 SERTM1 SFTPC SGMS2 SLC13A3 SLC30A3 SLC34A3 SLC35A1 SLC35B4 SLC38A7 SLC41A2 SLC61A1 SMAGP SNORC ST6GAL2 STX3 STX8 SYT15 SYT15B TF THBD TIMMDC1 TM4SF4 TMBIM6 TMEM107 TMEM109 TMEM11 TMEM120B TMEM128 TMEM14B TMEM14C TMEM19 TMEM203 TMEM218 TMEM229B TMEM243 TMEM254 TMEM42 TMEM50B TMEM60 TMEM86A TMEM86B TMEM97 TMPRSS4 TMUB2 TRAM1L1 TSPAN33 TSPO2 UNC50 UPK1B VAMP3 VAMP4 VAMP5 VKORC1L1 VSTM1 VTI1B YIF1A YIPF6 ZDHHC22	55 interacting genes: ABHD4 AQP2 AQP6 ARL13B ATP6V0B BIK CD40 CD79A CPLX4 CREB3L1 CYBC1 EBP ELOVL4 ERGIC3 FAM209A FAM210B GJA8 GOLM1 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LAPTM5 LHFPL5 LMNA MMGT1 MTIF3 MUC1 NEMP1 PCK1 PRLR PSCA PSMA7 PSMB1 PSMC3 PSMC5 PVR RNF5 SCAP SCN3B SLC10A1 SLC16A10 SLC18A1 SLC35H1 SREBF2 STIM1 TMEM14B TMEM237 TMEM45B TMEM52B TMX2 VCP VMA21
Entrez ID		493869	51141
HPRD ID		17416	16361
Ensembl ID		ENSG00000164294	ENSG00000125629
Uniprot IDs		B4DPY0 E7ETY7 J3KNB5 Q8TED1	B4DQ23 Q9Y5U4
PDB IDs		3CYN 3KIJ	4J82 6M49 7ETW
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding Plasma Membrane SNAP Receptor Activity SNARE Complex Golgi Membrane Cholesterol Binding Water Channel Activity Glycerol Transmembrane Transport Transmembrane Transport Channel Activity Renal Water Transport Polyol Transmembrane Transport Glycerol Transmembrane Transporter Activity Vesicle-mediated Transport Lysosomal Membrane Presynaptic Endosome Membrane Alkenylglycerophosphocholine Hydrolase Activity Water Transport Golgi Apparatus Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Lipid Metabolic Process Cellular Response To Mercury Ion Ascorbate Homeostasis ER To Golgi Transport Vesicle Membrane Endomembrane System Lysosome Organelle Fusion Fluid Transport Vesicle Fusion SNARE Binding Carbohydrate Binding Transmembrane Monodehydroascorbate Reductase Activity Membrane Destabilizing Activity Compact Myelin Transmembrane Ascorbate Ferrireductase Activity Respiratory Burst After Phagocytosis Organelle Membrane Fusion Monoatomic Ion Transport Sterol Biosynthetic Process Renal Water Homeostasis Metal Ion Transport Negative Regulation Of Lipoprotein Metabolic Process Water Transmembrane Transporter Activity Late Endosome Membrane Leukotriene-C4 Synthase Activity Membrane Fusion	Membrane Endoplasmic Reticulum Membrane Proteasome Complex Endoplasmic Reticulum C-8 Sterol Isomerase Activity Positive Regulation Of Cholesterol Biosynthetic Process Cytoplasmic Vesicle Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process Proteasome-activating Activity Positive Regulation Of Steroid Biosynthetic Process Protein Binding Renal Water Transport Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process SREBP Signaling Pathway Cellular Response To Sterol Depletion Regulation Of Cholesterol Metabolic Process Response To Sterol Depletion Proteasome Regulatory Particle, Base Subcomplex
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?