IL2RA and IL2

Number of citations of the paper that reports this interaction (PubMedID 1993646)
0

Data Source:
HPRD (in vivo)

		IL2RA	IL2
Description		interleukin 2 receptor subunit alpha	interleukin 2
Image
GO Annotations	Cellular Component	Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane Cell Surface Membrane	Extracellular Region Extracellular Space
	Molecular Function	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding	Cytokine Activity Interleukin-2 Receptor Binding Protein Binding Growth Factor Activity Kinase Activator Activity Carbohydrate Binding Kappa-type Opioid Receptor Binding Glycosphingolipid Binding
	Biological Process	Immune System Process Inflammatory Response To Antigenic Stimulus Regulation Of T Cell Tolerance Induction Regulation Of Immune System Process Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Interleukin-2-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation T Cell Homeostasis Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Lymphocyte Proliferation Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Activated T Cell Proliferation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Adaptive Immune Response Leukocyte Activation Involved In Immune Response Immune System Process Positive Regulation Of Immunoglobulin Production Negative Regulation Of B Cell Apoptotic Process Transcription By RNA Polymerase II Immune Response Cell Adhesion G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Gene Expression Natural Killer Cell Activation T Cell Differentiation Positive Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Positive Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Tissue Remodeling Interleukin-2-mediated Signaling Pathway T Cell Proliferation Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of Apoptotic Process Response To Ethanol Positive Regulation Of T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of T Cell Homeostatic Proliferation Lymphocyte Proliferation Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Activated T Cell Proliferation Positive Regulation Of Dendritic Spine Development Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Plasma Cell Differentiation Response To Tacrolimus Negative Regulation Of T-helper 17 Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways		RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling	RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab Inolimomab Camidanlumab tesirine	Pseudoephedrine Cefazolin SP4160 N(2)-carbamimidoyl-N-{2-[4-(3-{4-[(5-carboxyfuran-2-yl)methoxy]-2,3-dichlorophenyl}-1-methyl-1H-pyrazol-5-yl)piperidin-1-yl]-2-oxoethyl}-D-leucinamide 3-Mercapto-1-(1,3,4,9-Tetrahydro-B-Carbolin-2-Yl)-Propan-1-One Methyl (2S)-2-[[2-[(3R)-1-carbamimidoylpiperidin-3-yl]acetyl]amino]-3-[4-(2-phenylethynyl)phenyl]propanoate (1H-indol-3-yl)-(2-mercapto-ethoxyimino)-acetic acid SP2456 2-[2-(2-Cyclohexyl-2-guanidino-acetylamino)-acetylamino]-N-(3-mercapto-propyl)-propionamide Keyhole limpet hemocyanin Girentuximab TG4010
Diseases		Type I diabetes mellitus T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma	Graft-versus-host disease Type I diabetes mellitus
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Alopecia areata ( 20596022 25608926) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 34103634 31959851 31619474 31361310 30929738 32296059) Asthma (adult onset) ( 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 30929738) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diisocyanate-induced asthma ( 25918132) Eczema ( 31361310) Emotional dysregulation ( 27643478) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Graves' disease ( 22922229) Inflammatory biomarkers ( 22228203) Inflammatory bowel disease ( 23128233) Interleukin-2 receptor antagonist levels ( 27989323) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Lymphocyte count ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Marginal zone lymphoma or multiple sclerosis ( 31407831) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 19525953 17660530 19525955 21833088 28445677 24076602 22190364 27386562) Neutrophil percentage of white cells ( 32888494) Pediatric autoimmune diseases ( 26301688) Plasma t-tau levels ( 28100725) Primary sclerosing cholangitis ( 27992413 23603763) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 30572963 30423114 24449572 24390342 23143596) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 30572963 25751624 22293688 21829393 19430480 18978792) Vitiligo ( 27723757 20410501) White blood cell count ( 32888494)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406) Allergic rhinitis ( 30013184) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Alopecia areata ( 25608926 20596022) Asthma ( 31619474 31361310 31959851 30929738) Asthma (adult onset) ( 30929738) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 25574825 23727859 26482879) Bipolar disorder ( 31043756) Celiac disease ( 24999842 25920553 22057235 20190752 17558408 18311140) Crohn's disease ( 28067908) Eosinophil count ( 32888494) IgE grass sensitization ( 22036096) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Medication use (adrenergics, inhalants) ( 31015401) Primary sclerosing cholangitis ( 27992413 23603763) Progressive supranuclear palsy ( 21685912) Rheumatoid arthritis ( 30423114 24390342) Selective IgA deficiency ( 27723758) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 19430480 21829393 25751624) Ulcerative colitis ( 21297633) Vaso-occlusive pain in sickle-cell anemia ( 28584135)
Interacting Genes		8 interacting genes: CD4 ICAM1 IL2 IL2RB NFKB1 SNTA1 STAT3 STAT5B	9 interacting genes: CD53 FOXK2 IFNA1 IL2RA IL2RB IL2RG NGFR S100A6 SHC1
Entrez ID		3559	3558
HPRD ID		00986	00979
Ensembl ID		ENSG00000134460	ENSG00000109471
Uniprot IDs		H0Y5Z0 P01589 Q5W005	P60568 Q0GK43
PDB IDs		1Z92 2B5I 2ERJ 3IU3 3NFP 6VWU 6YIO 7F9W 7ZMZ	1IRL 1M47 1M48 1M49 1M4A 1M4B 1M4C 1NBP 1PW6 1PY2 1QVN 1Z92 2B5I 2ERJ 3INK 3QAZ 3QB1 4NEJ 4NEM 5LQB 5M5E 5UTZ 6LX3 6LXW 6VWU 6YE3 7DR4 7M2G 7RA9 7RAA 7YZJ 7ZMZ 8SOW 8SOZ 8WYR 8WYS
Enriched GO Terms of Interacting Partners?		Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Nuclear Glucocorticoid Receptor Binding Cytokine-mediated Signaling Pathway Response To Peptide Response To Cytokine Positive Regulation Of Inflammatory Response Cellular Response To Interleukin-17 Activated T Cell Proliferation Cellular Response To Cytokine Stimulus Regulation Of Vitamin Metabolic Process Cell Surface Receptor Signaling Pathway Via STAT Immune Response Progesterone Metabolic Process Growth Hormone Receptor Signaling Pathway Via JAK-STAT Response To Alcohol Regulation Of Monoatomic Cation Transmembrane Transport Intracellular Signaling Cassette Regulation Of Monoatomic Ion Transmembrane Transport Positive Regulation Of Cell Population Proliferation Response To Estradiol Positive Regulation Of T Cell Proliferation Adaptive Immune Response Positive Regulation Of Myeloid Cell Differentiation T Cell Activation Positive Regulation Of B Cell Differentiation Transcription By RNA Polymerase II Negative Regulation Of Small Molecule Metabolic Process Regulation Of Steroid Metabolic Process Response To Ethanol Growth Hormone Receptor Signaling Pathway C21-steroid Hormone Metabolic Process Regulation Of Metal Ion Transport Sex Differentiation Positive Regulation Of Activated T Cell Proliferation Cellular Response To Hormone Stimulus Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation Regulation Of Transport Sodium Channel Regulator Activity Immune Effector Process Signal Transduction Regulation Of Monoatomic Ion Transport Regulation Of Cell Population Proliferation Positive Regulation Of Leukocyte Proliferation Positive Regulation Of Interleukin-2 Production Regulation Of Sodium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Regulation Of Inflammatory Response	Interleukin-2 Binding Interleukin-2 Receptor Activity Interleukin-2-mediated Signaling Pathway Interleukin-2 Receptor Complex Interleukin-15 Receptor Activity Cell Surface Receptor Signaling Pathway Coreceptor Activity Interleukin-15-mediated Signaling Pathway Signal Transduction Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Cytokine Receptor Activity Positive Regulation Of Developmental Process Positive Regulation Of MiRNA Transcription Positive Regulation Of Fibroblast Proliferation Growth Factor Dependent Regulation Of Skeletal Muscle Satellite Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway T Cell Activation Positive Regulation Of MiRNA Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Regulation Of Animal Organ Morphogenesis Response To Wortmannin Positive Regulation Of Inner Ear Receptor Cell Differentiation Regulation Of MiRNA Transcription Positive Regulation Of Cell Fate Specification Positive Regulation Of Lens Fiber Cell Differentiation Positive Regulation Of Inner Ear Auditory Receptor Cell Differentiation Regulation Of CD4-positive, Alpha-beta T Cell Activation External Side Of Plasma Membrane Positive Regulation Of Phagocytosis Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Intracellular Glucose Homeostasis Positive Regulation Of Odontogenesis Of Dentin-containing Tooth Dorsal Aorta Development Shc-EGFR Complex Regulation Of MiRNA Metabolic Process Regulation Of Fibroblast Proliferation Regulation Of Cell Population Proliferation Positive Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor Angiogenesis Involved In Coronary Vascular Morphogenesis Regulation Of Retinal Cell Programmed Cell Death Lymphatic Endothelial Cell Migration Positive Regulation Of Cell Development Corticotropin Hormone Secreting Cell Differentiation
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