IL2RA and STAT5B

Number of citations of the paper that reports this interaction (PMID 10602027)
5

Data Source:
HPRD (in vivo)

		IL2RA	STAT5B
Gene Name		interleukin 2 receptor, alpha	signal transducer and activator of transcription 5B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Interleukin-2 Receptor Activity Drug Binding Interleukin-2 Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding Chromatin Binding Double-stranded DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Signal Transducer Activity Protein Binding Protein Phosphatase Binding Glucocorticoid Receptor Binding Protein Dimerization Activity
	Biological Process	Inflammatory Response To Antigenic Stimulus Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Interleukin-2-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response	Allantoin Metabolic Process Luteinization Response To Hypoxia Natural Killer Cell Differentiation Liver Development Citrate Metabolic Process 2-oxoglutarate Metabolic Process Succinate Metabolic Process Oxaloacetate Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Isoleucine Metabolic Process Valine Metabolic Process Creatine Metabolic Process Fatty Acid Metabolic Process Acute-phase Response JAK-STAT Cascade Female Pregnancy Lactation Regulation Of Steroid Metabolic Process Taurine Metabolic Process Lipid Storage Regulation Of Epithelial Cell Differentiation Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Natural Killer Cell Proliferation Positive Regulation Of Natural Killer Cell Differentiation Cellular Response To Hormone Stimulus T Cell Differentiation In Thymus Prolactin Signaling Pathway Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Positive Regulation Of Activated T Cell Proliferation Progesterone Metabolic Process T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Response To Ethanol Positive Regulation Of B Cell Differentiation Positive Regulation Of Gamma-delta T Cell Differentiation Negative Regulation Of Erythrocyte Differentiation Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Creatinine Metabolic Process Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Peyer's Patch Development Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cellular Component Movement JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Response To Interleukin-2 Response To Interleukin-4 Response To Interleukin-15 Cellular Response To Growth Factor Stimulus Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling	Signaling by PDGF Signaling by FGFR in disease Cytokine Signaling in Immune system Signaling by ERBB4 Signaling by SCF-KIT Signaling by Interleukins Nuclear signaling by ERBB4 Downstream signal transduction Signaling by FGFR1 mutants Interleukin-7 signaling Signaling by FGFR mutants Interleukin-2 signaling Prolactin receptor signaling Signaling by FGFR1 fusion mutants Interleukin-3, 5 and GM-CSF signaling Signaling by Leptin Growth hormone receptor signaling
Drugs		Denileukin diftitox Aldesleukin Basiliximab Daclizumab	Dasatinib
Diseases
GWAS		Alopecia areata ( 20596022) Asthma (bronchodilator response) ( 23508266) Crohn's disease ( 21102463) Inflammatory biomarkers ( 22228203) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 19525953 19525955 17660530 21833088) Rheumatoid arthritis ( 20453842) Type 1 diabetes ( 19430480 22293688 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 20410501)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		8 interactors: CD4 ICAM1 IL2 IL2RB NFKB1 SNTA1 STAT3 STAT5B	49 interactors: AFTPH APP CBL CD247 CENPJ CRK CRKL CTLA4 CXCR4 DMRTA1 EGFR ELP2 EP300 EPOR ERBB4 ETS1 ETS2 GHR HAX1 IL15 IL2RA IL2RB IL7R INSR JAK2 JAK3 KIT MAPK1 NCOR2 NMI NR3C1 PDGFRA PDGFRB POU2F1 PPP2CA PTPN1 PTPN11 PTPN2 PTPN6 RARA SERTAD1 SHC1 SRC STAP2 STAT1 STAT3 STAT5A TEK TFG
Entrez ID		3559	6777
HPRD ID		00986	05037
Ensembl ID		ENSG00000134460	ENSG00000173757
Uniprot IDs		P01589 Q5W005	P51692
PDB IDs		1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cell Death Cellular Response To Cytokine Stimulus Response To Cytokine T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Acute Inflammatory Response Regulation Of Cell Death Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Positive Regulation Of Cellular Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Interleukin-2 Negative Regulation Of Programmed Cell Death Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cytokine Biosynthetic Process Cell Surface Receptor Signaling Pathway Lymphocyte Activation Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Organonitrogen Compound Response To Bacterium Response To Ethanol Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Metabolic Process Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Viral Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Signal Transduction Response To Copper Ion Positive Regulation Of Activated T Cell Proliferation Regulation Of Immune System Process Regulation Of Interleukin-2 Biosynthetic Process Growth Hormone Receptor Signaling Pathway Defense Response Cellular Response To Growth Hormone Stimulus Regulation Of Cell Adhesion Cellular Response To Interleukin-6 Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation	Cellular Response To Organic Substance Response To Organic Substance Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Immune Response Response To Hormone Regulation Of MAPK Cascade Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cellular Metabolic Process Response To Cytokine Cell Surface Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Phosphorylation Regulation Of Signal Transduction Growth Hormone Receptor Signaling Pathway Regulation Of Protein Phosphorylation Cellular Response To Hormone Stimulus Cellular Response To Growth Hormone Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Signal Transduction Immune Response Signaling Regulation Of Phosphorus Metabolic Process Signal Transduction JAK-STAT Cascade Positive Regulation Of MAPK Cascade Defense Response Cell Communication Regulation Of Signaling Cellular Response To Organonitrogen Compound Positive Regulation Of Metabolic Process Immune System Process Cellular Response To Cytokine Stimulus Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Organ Development Cellular Response To Peptide Response To Growth Hormone Positive Regulation Of Phosphorylation Cellular Response To Stimulus Regulation Of Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Peptidyl-tyrosine Phosphorylation Regulation Of Protein Metabolic Process Response To Peptide Hormone Positive Regulation Of Transferase Activity Innate Immune Response
Tagcloud ?		artp calculating chief convergence dusp2 hrgg il6 il8ra il8rb infgr1 irf2 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stats yeast
Tagcloud (Difference) ?		artp calculating chief convergence dusp2 hrgg il6 il8ra il8rb infgr1 irf2 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	augment augments bait cbp coactivator coil coiled enhances except hybrid ifngamma instead interactor interacts interestingly intrinsic lacks myc nmi potentiate recruitment reveal screen stat1 stat2 stats yeast
Tagcloud (Intersection) ?