FRA10AC1 and CWC27

Number of citations of the paper that reports this interaction (PMID 22365833)
24

Data Source:
BioGRID (two hybrid)

		FRA10AC1	CWC27
Gene Name		fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1	CWC27 spliceosome-associated protein homolog (S. cerevisiae)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus	Catalytic Step 2 Spliceosome
	Molecular Function	Protein Binding	Peptidyl-prolyl Cis-trans Isomerase Activity
	Biological Process		MRNA Splicing, Via Spliceosome Protein Peptidyl-prolyl Isomerization Protein Folding
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		27 interactors: ADPRHL2 C21orf33 C7orf25 CCDC155 CHERP CWC27 DGCR14 EEF1D GDPD2 GLRX3 HABP4 IK LPPR4 MAP3K12 MFAP1 NKAP PRPF3 PRPF40A SAP30BP SF3B2 THOC1 TRIM41 TTC14 U2AF1 VPS29 ZCCHC10 ZNF830	2 interactors: FRA10AC1 HMGA1
Entrez ID		118924	10283
HPRD ID		12319	11541
Ensembl ID		ENSG00000148690	ENSG00000153015
Uniprot IDs		Q70Z53	D6REK3 Q6UX04
PDB IDs			2HQ6
Enriched GO Terms of Interacting Partners?		RNA Splicing RNA Processing MRNA Processing MRNA Metabolic Process MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Cellular Metabolic Process Chromosome Localization To Nuclear Envelope Involved In Synapsis Negative Regulation Of Isotype Switching To IgA Isotypes MRNA Export From Nucleus RNA Export From Nucleus Metabolic Process Intestinal Epithelial Structure Maintenance	Oncogene-induced Cell Senescence Senescence-associated Heterochromatin Focus Assembly Positive Regulation Of Cellular Senescence Negative Regulation Of Chromatin Silencing Establishment Of Integrated Proviral Latency Positive Regulation Of Cell Aging Establishment Of Viral Latency Heterochromatin Assembly DNA Unwinding Involved In DNA Replication Nucleosome Disassembly Heterochromatin Organization Positive Regulation Of Gene Expression, Epigenetic Regulation Of Gene Silencing Regulation Of Cellular Senescence Cellular Senescence Base-excision Repair Cell Aging DNA Duplex Unwinding DNA Geometric Change DNA Catabolic Process, Endonucleolytic DNA-dependent DNA Replication Chromatin Assembly DNA Catabolic Process Nucleosome Organization Chromatin Assembly Or Disassembly Chromatin Remodeling DNA Packaging Protein Complex Disassembly Regulation Of Gene Expression, Epigenetic Response To Virus DNA Replication DNA Conformation Change Nucleic Acid Phosphodiester Bond Hydrolysis Aging
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