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FRA10AC1 and MAP3K12
Number of citations of the paper that reports this interaction (PMID
16169070
)
531
Data Source:
BioGRID
(pull down)
HPRD
(two hybrid)
FRA10AC1
MAP3K12
Gene Name
fragile site, folic acid type, rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1
mitogen-activated protein kinase kinase kinase 12
Image
No pdb structure
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Axon
Growth Cone
Molecular Function
Protein Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Kinase Kinase Activity
Protein Binding
ATP Binding
Protein Kinase Binding
Protein Homodimerization Activity
Biological Process
Activation Of MAPKK Activity
Protein Phosphorylation
JNK Cascade
Histone Phosphorylation
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Intracellular Signal Transduction
Protein Autophosphorylation
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions
27 interactors:
ADPRHL2
C21orf33
C7orf25
CCDC155
CHERP
CWC27
DGCR14
EEF1D
GDPD2
GLRX3
HABP4
IK
LPPR4
MAP3K12
MFAP1
NKAP
PRPF3
PRPF40A
SAP30BP
SF3B2
THOC1
TRIM41
TTC14
U2AF1
VPS29
ZCCHC10
ZNF830
15 interactors:
EGFR
FRA10AC1
FTL
MAP2K4
MAP2K7
MAP3K11
MAPK6
MAPK8IP1
MAPK8IP2
MBIP
RGS1
RPL18A
SH3RF1
TGM2
TSC22D1
Entrez ID
118924
7786
HPRD ID
12319
02709
Ensembl ID
ENSG00000148690
ENSG00000139625
Uniprot IDs
Q70Z53
Q12852
PDB IDs
Enriched GO Terms of Interacting Partners
?
RNA Splicing
RNA Processing
MRNA Processing
MRNA Metabolic Process
MRNA Splicing, Via Spliceosome
RNA Splicing, Via Transesterification Reactions
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Gene Expression
Cellular Nitrogen Compound Metabolic Process
Nitrogen Compound Metabolic Process
Cellular Metabolic Process
Chromosome Localization To Nuclear Envelope Involved In Synapsis
Negative Regulation Of Isotype Switching To IgA Isotypes
MRNA Export From Nucleus
RNA Export From Nucleus
Metabolic Process
Intestinal Epithelial Structure Maintenance
MAPK Cascade
Signal Transduction By Phosphorylation
Regulation Of JNK Cascade
Regulation Of MAPK Cascade
Regulation Of Stress-activated MAPK Cascade
JNK Cascade
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Regulation Of MAP Kinase Activity
Regulation Of Protein Kinase Activity
Regulation Of Intracellular Signal Transduction
Regulation Of Kinase Activity
Regulation Of JUN Kinase Activity
Regulation Of Phosphorylation
Regulation Of Signal Transduction
Regulation Of Apoptotic Process
Regulation Of Phosphorus Metabolic Process
Regulation Of Cell Death
Regulation Of Signaling
Regulation Of Protein Phosphorylation
Positive Regulation Of Stress-activated MAPK Cascade
Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade
Regulation Of Catalytic Activity
Activation Of JUN Kinase Activity
Cellular Response To Sorbitol
Positive Regulation Of Signal Transduction
Positive Regulation Of Intracellular Signal Transduction
Positive Regulation Of MAPK Cascade
Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Kinase Activity
Peptidyl-amino Acid Modification
Regulation Of Protein Metabolic Process
Positive Regulation Of JUN Kinase Activity
Positive Regulation Of Neuron Death
Positive Regulation Of Transferase Activity
Positive Regulation Of Apoptotic Process
Activation Of Protein Kinase Activity
Positive Regulation Of Programmed Cell Death
Cellular Protein Modification Process
Positive Regulation Of Protein Serine/threonine Kinase Activity
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Cell Death
Cellular Protein Metabolic Process
Phosphorylation
Intracellular Signal Transduction
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of JNK Cascade
Tagcloud
?
adipocytes
adipogenesis
adipogenic
adipose
ascs
bisphenol
bpa
ccaat
cebpa
disrupter
dlk
dye
ebpalpha
esr1
ici
igf1
leucine
lipase
lpl
peroxisome
physiologically
pparg
ppargamma
precursors
proliferator
retained
temporally
visualize
zipper
Tagcloud (Difference)
?
adipocytes
adipogenesis
adipogenic
adipose
ascs
bisphenol
bpa
ccaat
cebpa
disrupter
dlk
dye
ebpalpha
esr1
ici
igf1
leucine
lipase
lpl
peroxisome
physiologically
pparg
ppargamma
precursors
proliferator
retained
temporally
visualize
zipper
Tagcloud (Intersection)
?