IHH and RHOD

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IHH	RHOD
Gene Name		indian hedgehog	ras homolog family member D
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Extracellular Matrix	Early Endosome Cytosol Plasma Membrane
	Molecular Function	Patched Binding Calcium Ion Binding Peptidase Activity	GTPase Activity GTP Binding Protein Kinase Binding
	Biological Process	Skeletal System Development Patterning Of Blood Vessels Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Proteoglycan Metabolic Process Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Embryonic Pattern Specification Negative Regulation Of Signal Transduction Intein-mediated Protein Splicing Vitelline Membrane Formation Pancreas Development Positive Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Multicellular Organism Growth Chondrocyte Proliferation Regulation Of Growth Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Eye Pigmentation Cell Maturation Embryonic Digestive Tract Morphogenesis Embryonic Camera-type Eye Morphogenesis Neuron Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Maternal Process Involved In Female Pregnancy Camera-type Eye Photoreceptor Cell Fate Commitment Head Morphogenesis Somite Development Embryonic Skeletal Joint Development Epithelial Cell-cell Adhesion	Protein Targeting Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Metabolic Process Lamellipodium Assembly Positive Regulation Of Cell Migration Positive Regulation Of Cell Adhesion Focal Adhesion Assembly Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Focal Adhesion Assembly Regulation Of Actin Cytoskeleton Reorganization
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease GPCR ligand binding Metabolic disorders of biological oxidation enzymes Ligand-receptor interactions Release of Hh-Np from the secreting cell Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors)	Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS		Height ( 20881960 18391951 18391952 20189936)	Height ( 20881960)
Protein-Protein Interactions		4 interactors: HHIP PTCH1 PTCH2 RHOD	14 interactors: ACVR1 ADCK5 ADRB2 ANKFY1 ARHGAP29 BMPR1B DIAPH2 HRAS IHH PLXNA1 SMAD2 SMAD4 SMURF2 TGFBR1
Entrez ID		3549	29984
HPRD ID		02839	05776
Ensembl ID		ENSG00000163501	ENSG00000173156
Uniprot IDs		Q14623	E9PIG5 O00212
PDB IDs		3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P	2J1L
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Regulation Of Signal Transduction Regulation Of Signaling Neural Plate Axis Specification Response To Chlorate Epithelium Development Negative Regulation Of Signal Transduction Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Signaling Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Epidermis Development Tissue Development Cell Proliferation Involved In Metanephros Development Epithelial Tube Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Protein Targeting Tube Morphogenesis Cell Proliferation Involved In Kidney Development Keratinocyte Proliferation Pattern Specification Process Cellular Response To Cholesterol Signal Transduction Neural Plate Development Morphogenesis Of An Epithelium Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Multicellular Organism Growth Signaling Positive Regulation Of Cholesterol Transport Mammary Gland Epithelial Cell Differentiation Cell Communication Response To Cholesterol Pharyngeal System Development Regulation Of Cholesterol Efflux Tissue Morphogenesis Tube Development Cell Proliferation Focal Adhesion Assembly Dorsal/ventral Neural Tube Patterning Cellular Response To Stimulus Regulation Of Cholesterol Transport Cell Differentiation Involved In Kidney Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Protein Targeting To Plasma Membrane Spinal Cord Motor Neuron Differentiation	Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Positive Regulation Of Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Organ Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Response To Transforming Growth Factor Beta BMP Signaling Pathway Cell Development Pattern Specification Process Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Fate Commitment Activin Receptor Signaling Pathway Cellular Response To Growth Factor Stimulus Response To Growth Factor Regulation Of Signaling Cell Surface Receptor Signaling Pathway Tissue Morphogenesis Negative Regulation Of Cell Proliferation Tissue Development Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Bone Mineralization Cell Morphogenesis Involved In Differentiation Positive Regulation Of Biomineral Tissue Development Cell Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Epithelial To Mesenchymal Transition Tube Morphogenesis Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Cellular Response To Growth Factor Stimulus Positive Regulation Of Transcription, DNA-templated Mesenchyme Development Endocardial Cell Differentiation Branching Morphogenesis Of An Epithelial Tube Heart Morphogenesis In Utero Embryonic Development Morphogenesis Of An Epithelium Heart Development Endothelial Cell Activation Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Stem Cell Development Regulation Of Bone Mineralization Positive Regulation Of Gene Expression Signal Transduction Germ Cell Development
Tagcloud ?		absent consequence defective deficiency diminished elevated etiology finding gnrh hypogonadism hypogonadotropic idiopathic implicated individually irrespective kallmann ks lh matched melatonin metabolite nighttime nocturnal principle pulsatility recruited respective sulphatoxymelatonin unlikely	10nm 130nm 400nm 500ms 50nm 5x100hz bapta brevis buffering carbonylcyanide ctrl digitorum electrically electroporation fccp fdb flexor fluo footpads mag mfn2 mitofusin myoplasmic sarcomere tetani tetanic tethers transients trifluoromethoxyphenylhydrazone
Tagcloud (Difference) ?		absent consequence defective deficiency diminished elevated etiology finding gnrh hypogonadism hypogonadotropic idiopathic implicated individually irrespective kallmann ks lh matched melatonin metabolite nighttime nocturnal principle pulsatility recruited respective sulphatoxymelatonin unlikely	10nm 130nm 400nm 500ms 50nm 5x100hz bapta brevis buffering carbonylcyanide ctrl digitorum electrically electroporation fccp fdb flexor fluo footpads mag mfn2 mitofusin myoplasmic sarcomere tetani tetanic tethers transients trifluoromethoxyphenylhydrazone
Tagcloud (Intersection) ?