IHH and PTCH1

Number of citations of the paper that reports this interaction (PMID 9811851)
27

Data Source:
HPRD (in vivo)

		IHH	PTCH1
Gene Name		indian hedgehog	patched 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Extracellular Matrix	Golgi Apparatus Plasma Membrane Caveola Postsynaptic Density Integral Component Of Membrane Midbody Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Ciliary Membrane Primary Cilium
	Molecular Function	Patched Binding Calcium Ion Binding Peptidase Activity	Patched Binding Smoothened Binding Protein Binding Hedgehog Receptor Activity Heparin Binding Cholesterol Binding Cyclin Binding Protein Complex Binding Hedgehog Family Protein Binding
	Biological Process	Skeletal System Development Patterning Of Blood Vessels Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Proteoglycan Metabolic Process Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Embryonic Pattern Specification Negative Regulation Of Signal Transduction Intein-mediated Protein Splicing Vitelline Membrane Formation Pancreas Development Positive Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Multicellular Organism Growth Chondrocyte Proliferation Regulation Of Growth Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Eye Pigmentation Cell Maturation Embryonic Digestive Tract Morphogenesis Embryonic Camera-type Eye Morphogenesis Neuron Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Maternal Process Involved In Female Pregnancy Camera-type Eye Photoreceptor Cell Fate Commitment Head Morphogenesis Somite Development Embryonic Skeletal Joint Development Epithelial Cell-cell Adhesion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Branching Involved In Ureteric Bud Morphogenesis In Utero Embryonic Development Neural Tube Closure Heart Morphogenesis Smoothened Signaling Pathway Regulation Of Mitotic Cell Cycle Brain Development Epidermis Development Regulation Of Smoothened Signaling Pathway Response To Mechanical Stimulus Organ Morphogenesis Dorsal/ventral Pattern Formation Response To Chlorate Positive Regulation Of Cholesterol Efflux Protein Processing Spinal Cord Motor Neuron Differentiation Neural Tube Patterning Neural Plate Axis Specification Embryonic Limb Morphogenesis Response To Estradiol Response To Retinoic Acid Regulation Of Protein Localization Limb Morphogenesis Hindlimb Morphogenesis Negative Regulation Of Multicellular Organism Growth Response To Drug Glucose Homeostasis Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Keratinocyte Proliferation Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Embryonic Organ Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cell Division Pharyngeal System Development Mammary Gland Duct Morphogenesis Mammary Gland Epithelial Cell Differentiation Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Cell Differentiation Involved In Kidney Development Somite Development Cellular Response To Cholesterol Renal System Development Cell Proliferation Involved In Metanephros Development Protein Targeting To Plasma Membrane
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease GPCR ligand binding Metabolic disorders of biological oxidation enzymes Ligand-receptor interactions Release of Hh-Np from the secreting cell Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog 'off' state Hedgehog 'on' state Signaling by Hedgehog Metabolic disorders of biological oxidation enzymes GPCR ligand binding Ligand-receptor interactions Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Height ( 20881960 18391951 18391952 20189936)	Height ( 18391952) Pulmonary function ( 20010835) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		4 interactors: HHIP PTCH1 PTCH2 RHOD	7 interactors: CCNB1 CDK1 DHH HIPK2 IHH SHH SMO
Entrez ID		3549	5727
HPRD ID		02839	03200
Ensembl ID		ENSG00000163501	ENSG00000185920
Uniprot IDs		Q14623	Q13635 Q59FG5
PDB IDs		3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Regulation Of Signal Transduction Regulation Of Signaling Neural Plate Axis Specification Response To Chlorate Epithelium Development Negative Regulation Of Signal Transduction Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Signaling Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Epidermis Development Tissue Development Cell Proliferation Involved In Metanephros Development Epithelial Tube Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Protein Targeting Tube Morphogenesis Cell Proliferation Involved In Kidney Development Keratinocyte Proliferation Pattern Specification Process Cellular Response To Cholesterol Signal Transduction Neural Plate Development Morphogenesis Of An Epithelium Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Multicellular Organism Growth Signaling Positive Regulation Of Cholesterol Transport Mammary Gland Epithelial Cell Differentiation Cell Communication Response To Cholesterol Pharyngeal System Development Regulation Of Cholesterol Efflux Tissue Morphogenesis Tube Development Cell Proliferation Focal Adhesion Assembly Dorsal/ventral Neural Tube Patterning Cellular Response To Stimulus Regulation Of Cholesterol Transport Cell Differentiation Involved In Kidney Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Protein Targeting To Plasma Membrane Spinal Cord Motor Neuron Differentiation	Muscle Tissue Development Positive Regulation Of Cell Proliferation Smoothened Signaling Pathway Digestive Tract Development Digestive System Development Intein-mediated Protein Splicing Heart Development Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Striated Muscle Cell Differentiation Positive Regulation Of Smoothened Signaling Pathway Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Organ Development Heart Looping Positive Regulation Of Hh Target Transcription Factor Activity Determination Of Heart Left/right Asymmetry Positive Regulation Of Striated Muscle Tissue Development Positive Regulation Of Muscle Tissue Development Embryonic Heart Tube Morphogenesis Cell Fate Commitment Determination Of Left/right Asymmetry In Lateral Mesoderm Signal Transduction Downstream Of Smoothened Positive Regulation Of Stem Cell Proliferation Striated Muscle Tissue Development Tissue Development Muscle Cell Differentiation Embryonic Organ Morphogenesis Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Ventral Midline Development Cardiovascular System Development Cell Development Cell Differentiation Response To Organic Cyclic Compound Embryonic Heart Tube Development Cell-cell Signaling Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Positive Regulation Of Protein Import Into Nucleus Regulation Of Smoothened Signaling Pathway Cell Fate Specification Pancreas Development Somite Development Negative Regulation Of Cell Death Epithelial-mesenchymal Cell Signaling Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Nucleocytoplasmic Transport Determination Of Left/right Symmetry Regulation Of Stem Cell Proliferation
Tagcloud ?		absent consequence defective deficiency diminished elevated etiology finding gnrh hypogonadism hypogonadotropic idiopathic implicated individually irrespective kallmann ks lh matched melatonin metabolite nighttime nocturnal principle pulsatility recruited respective sulphatoxymelatonin unlikely	actinic basel brm constituents culminating damages destroying detrimental division drive enabling hras immunity immunosuppression incorrect interfere karger keratosis lipids mast mutagenesis photodamage photodamaged steps stops synthesised ultraviolet unrepaired uv
Tagcloud (Difference) ?		absent consequence defective deficiency diminished elevated etiology finding gnrh hypogonadism hypogonadotropic idiopathic implicated individually irrespective kallmann ks lh matched melatonin metabolite nighttime nocturnal principle pulsatility recruited respective sulphatoxymelatonin unlikely	actinic basel brm constituents culminating damages destroying detrimental division drive enabling hras immunity immunosuppression incorrect interfere karger keratosis lipids mast mutagenesis photodamage photodamaged steps stops synthesised ultraviolet unrepaired uv
Tagcloud (Intersection) ?