IHH and PTCH2

Number of citations of the paper that reports this interaction (PMID 9811851)
27

Data Source:
HPRD (in vivo)

		IHH	PTCH2
Gene Name		indian hedgehog	patched 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Extracellular Matrix	Integral Component Of Membrane
	Molecular Function	Patched Binding Calcium Ion Binding Peptidase Activity	Smoothened Binding Hedgehog Receptor Activity Hedgehog Family Protein Binding
	Biological Process	Skeletal System Development Patterning Of Blood Vessels Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Proteoglycan Metabolic Process Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Embryonic Pattern Specification Negative Regulation Of Signal Transduction Intein-mediated Protein Splicing Vitelline Membrane Formation Pancreas Development Positive Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Multicellular Organism Growth Chondrocyte Proliferation Regulation Of Growth Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Eye Pigmentation Cell Maturation Embryonic Digestive Tract Morphogenesis Embryonic Camera-type Eye Morphogenesis Neuron Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Maternal Process Involved In Female Pregnancy Camera-type Eye Photoreceptor Cell Fate Commitment Head Morphogenesis Somite Development Embryonic Skeletal Joint Development Epithelial Cell-cell Adhesion	Signal Transduction Epidermis Development Hair Cycle Negative Regulation Of Smoothened Signaling Pathway
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease GPCR ligand binding Metabolic disorders of biological oxidation enzymes Ligand-receptor interactions Release of Hh-Np from the secreting cell Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Metabolic disorders of biological oxidation enzymes GPCR ligand binding Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Height ( 20881960 18391951 18391952 20189936)
Protein-Protein Interactions		4 interactors: HHIP PTCH1 PTCH2 RHOD	4 interactors: DHH IHH SHH SMO
Entrez ID		3549	8643
HPRD ID		02839	04722
Ensembl ID		ENSG00000163501	ENSG00000117425
Uniprot IDs		Q14623	Q9Y6C5
PDB IDs		3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Regulation Of Signal Transduction Regulation Of Signaling Neural Plate Axis Specification Response To Chlorate Epithelium Development Negative Regulation Of Signal Transduction Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Signaling Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Epidermis Development Tissue Development Cell Proliferation Involved In Metanephros Development Epithelial Tube Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Protein Targeting Tube Morphogenesis Cell Proliferation Involved In Kidney Development Keratinocyte Proliferation Pattern Specification Process Cellular Response To Cholesterol Signal Transduction Neural Plate Development Morphogenesis Of An Epithelium Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Multicellular Organism Growth Signaling Positive Regulation Of Cholesterol Transport Mammary Gland Epithelial Cell Differentiation Cell Communication Response To Cholesterol Pharyngeal System Development Regulation Of Cholesterol Efflux Tissue Morphogenesis Tube Development Cell Proliferation Focal Adhesion Assembly Dorsal/ventral Neural Tube Patterning Cellular Response To Stimulus Regulation Of Cholesterol Transport Cell Differentiation Involved In Kidney Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Protein Targeting To Plasma Membrane Spinal Cord Motor Neuron Differentiation	Intein-mediated Protein Splicing Positive Regulation Of Mesenchymal Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Smoothened Signaling Pathway Heart Looping Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Hh Target Transcription Factor Activity Embryonic Heart Tube Development Determination Of Left/right Asymmetry In Lateral Mesoderm Signal Transduction Downstream Of Smoothened Regulation Of Smoothened Signaling Pathway Cell Fate Specification Pancreas Development Somite Development Smoothened Signaling Pathway Involved In Regulation Of Cerebellar Granule Cell Precursor Cell Proliferation Ventral Midline Development Determination Of Left/right Symmetry Regulation Of Stem Cell Proliferation Smoothened Signaling Pathway Determination Of Bilateral Symmetry Cerebellar Purkinje Cell-granule Cell Precursor Cell Signaling Involved In Regulation Of Granule Cell Precursor Cell Proliferation Epithelial-mesenchymal Cell Signaling Digestive Tract Development Osteoblast Differentiation Digestive System Development Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cerebellar Granule Cell Precursor Proliferation Lateral Mesoderm Development Thalamus Development Negative Regulation Of Alpha-beta T Cell Differentiation Cell-cell Signaling Positive Regulation Of T Cell Differentiation In Thymus Heart Morphogenesis Negative Regulation Of Alpha-beta T Cell Activation Ossification Regulation Of Epithelial Cell Proliferation Positive Regulation Of Neuroblast Proliferation Embryonic Digestive Tract Morphogenesis Cell Fate Commitment Spinal Cord Dorsal/ventral Patterning Embryonic Organ Morphogenesis Regulation Of T Cell Differentiation In Thymus Spinal Cord Patterning Muscle Tissue Development Hair Follicle Morphogenesis Negative Regulation Of T Cell Differentiation Dorsal/ventral Neural Tube Patterning Positive Regulation Of Kidney Development
Tagcloud ?		absent consequence defective deficiency diminished elevated etiology finding gnrh hypogonadism hypogonadotropic idiopathic implicated individually irrespective kallmann ks lh matched melatonin metabolite nighttime nocturnal principle pulsatility recruited respective sulphatoxymelatonin unlikely	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Difference) ?		absent consequence defective deficiency diminished elevated etiology finding gnrh hypogonadism hypogonadotropic idiopathic implicated individually irrespective kallmann ks lh matched melatonin metabolite nighttime nocturnal principle pulsatility recruited respective sulphatoxymelatonin unlikely	calm3 cblb ccna2 ccnd3 cdk6 cited1 dems dok elk3 fyn git1 hck lck module modules nonmodule p85beta pdgfra pib5pa psd93 sam68 sh3kbp1 shc tgfbr1 tgfbr2 vav2 wilcoxon yes zfyve9
Tagcloud (Intersection) ?