IHH

Gene Name		indian hedgehog
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Extracellular Matrix
	Molecular Function	Patched Binding Calcium Ion Binding Peptidase Activity
	Biological Process	Skeletal System Development Patterning Of Blood Vessels Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Proteoglycan Metabolic Process Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Embryonic Pattern Specification Negative Regulation Of Signal Transduction Intein-mediated Protein Splicing Vitelline Membrane Formation Pancreas Development Positive Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Multicellular Organism Growth Chondrocyte Proliferation Regulation Of Growth Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Eye Pigmentation Cell Maturation Embryonic Digestive Tract Morphogenesis Embryonic Camera-type Eye Morphogenesis Neuron Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Maternal Process Involved In Female Pregnancy Camera-type Eye Photoreceptor Cell Fate Commitment Head Morphogenesis Somite Development Embryonic Skeletal Joint Development Epithelial Cell-cell Adhesion
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease GPCR ligand binding Metabolic disorders of biological oxidation enzymes Ligand-receptor interactions Release of Hh-Np from the secreting cell Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Height ( 20881960 18391951 18391952 20189936)
Protein-protein Interactions		4 interactors: HHIP PTCH1 PTCH2 RHOD
Entrez ID		3549
HPRD ID		02839
Ensembl ID		ENSG00000163501
Uniprot IDs		Q14623
PDB IDs		3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Regulation Of Signal Transduction Regulation Of Signaling Neural Plate Axis Specification Response To Chlorate Epithelium Development Negative Regulation Of Signal Transduction Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Signaling Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Epidermis Development Tissue Development Cell Proliferation Involved In Metanephros Development Epithelial Tube Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Protein Targeting Tube Morphogenesis Cell Proliferation Involved In Kidney Development Keratinocyte Proliferation Pattern Specification Process Cellular Response To Cholesterol Signal Transduction Neural Plate Development Morphogenesis Of An Epithelium Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Multicellular Organism Growth Signaling Positive Regulation Of Cholesterol Transport Mammary Gland Epithelial Cell Differentiation Cell Communication Response To Cholesterol Pharyngeal System Development Regulation Of Cholesterol Efflux Tissue Morphogenesis Tube Development Cell Proliferation Focal Adhesion Assembly Dorsal/ventral Neural Tube Patterning Cellular Response To Stimulus Regulation Of Cholesterol Transport Cell Differentiation Involved In Kidney Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Protein Targeting To Plasma Membrane Spinal Cord Motor Neuron Differentiation
Tagcloud ?		absent consequence defective deficiency diminished elevated etiology finding gnrh hypogonadism hypogonadotropic idiopathic implicated individually irrespective kallmann ks lh matched melatonin metabolite nighttime nocturnal principle pulsatility recruited respective sulphatoxymelatonin unlikely