IHH

Description		Indian hedgehog signaling molecule
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane Extracellular Matrix
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Transferase Activity Hydrolase Activity Very-low-density Lipoprotein Particle Binding Metal Ion Binding Cholesterol-protein Transferase Activity
	Biological Process	Skeletal System Development Ossification Branching Involved In Blood Vessel Morphogenesis Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Morphogenesis Of A Branching Structure Vasculature Development Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Chondrocyte Differentiation Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Proteoglycan Metabolic Process Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Pattern Specification Process Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Response To Mechanical Stimulus Embryonic Pattern Specification Regulation Of Gene Expression Intein-mediated Protein Splicing Protein Autoprocessing Vitelline Membrane Formation Pancreas Development Negative Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Multicellular Organism Growth Chondrocyte Proliferation Regulation Of Growth Embryonic Digit Morphogenesis Camera-type Eye Development Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Eye Pigmentation Cell Maturation Embryonic Digestive Tract Morphogenesis Embryonic Camera-type Eye Morphogenesis Neuron Development System Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Maternal Process Involved In Female Pregnancy Camera-type Eye Photoreceptor Cell Fate Commitment Head Morphogenesis Somite Development Embryonic Skeletal Joint Development Epithelial Cell-cell Adhesion Self Proteolysis Liver Regeneration
Pathways		Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V doesn't palmitoylate Hh-Np RUNX2 regulates chondrocyte maturation Formation of lateral plate mesoderm
Drugs
Diseases		Acrocapitofemoral dysplasia Brachydactyly, including: type A; type B; type D; type E
GWAS		Height ( 18391951 18391952 20189936 20881960 31562340) Waist circumference adjusted for body mass index ( 26785701)
Interacting Genes		4 interacting genes: HHIP PTCH1 PTCH2 RHOD
Entrez ID		3549
HPRD ID		02839
Ensembl ID		ENSG00000163501
Uniprot IDs		Q14623
PDB IDs		3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P
Enriched GO Terms of Interacting Partners?		Hedgehog Family Protein Binding Negative Regulation Of Smoothened Signaling Pathway Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Regulation Of Smoothened Signaling Pathway Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Cell Fate Determination Ciliary Membrane Positive Regulation Of Epithelial Cell Differentiation Regulation Of Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Regulation Of Epidermis Development Cell Fate Specification Neural Plate Axis Specification Branching Morphogenesis Of An Epithelial Tube Epidermis Development Response To Chlorate Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Epithelial Cell Differentiation Regulation Of Signal Transduction Tube Morphogenesis Regulation Of Cell Communication Patched Binding Cell Proliferation Involved In Metanephros Development Mammary Gland Duct Morphogenesis Neural Tube Patterning Dendritic Growth Cone Regulation Of Signaling Regionalization Negative Regulation Of Signal Transduction Neural Tube Formation Metanephric Collecting Duct Development Morphogenesis Of An Epithelium Cell Proliferation Involved In Kidney Development Negative Regulation Of Cell Communication Negative Regulation Of Signaling Pattern Specification Process Negative Regulation Of Multicellular Organism Growth Commissural Neuron Axon Guidance Tissue Morphogenesis Collecting Duct Development Dorsal/ventral Neural Tube Patterning Hair Cycle Negative Regulation Of Cell Division Somite Development Prostate Gland Development Cellular Response To Cholesterol
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