IHH and HHIP

Number of citations of the paper that reports this interaction (PMID 10050855)
113

Data Source:
HPRD (in vivo)

		IHH	HHIP
Gene Name		indian hedgehog	hedgehog interacting protein
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Extracellular Matrix	Extracellular Region Cytoplasm Integral Component Of Plasma Membrane Cell Surface Ciliary Membrane
	Molecular Function	Patched Binding Calcium Ion Binding Peptidase Activity	Protein Binding Zinc Ion Binding Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, Quinone Or Similar Compound As Acceptor Quinone Binding Hedgehog Family Protein Binding
	Biological Process	Skeletal System Development Patterning Of Blood Vessels Osteoblast Differentiation In Utero Embryonic Development Cell Fate Specification Heart Looping Positive Regulation Of Mesenchymal Cell Proliferation Epithelial Cell Morphogenesis Retinal Pigment Epithelium Development Proteoglycan Metabolic Process Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Embryonic Pattern Specification Negative Regulation Of Signal Transduction Intein-mediated Protein Splicing Vitelline Membrane Formation Pancreas Development Positive Regulation Of Chondrocyte Differentiation Response To Estradiol Positive Regulation Of Collagen Biosynthetic Process Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of T Cell Differentiation In Thymus Multicellular Organism Growth Chondrocyte Proliferation Regulation Of Growth Negative Regulation Of Apoptotic Process Bone Resorption Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Eye Pigmentation Cell Maturation Embryonic Digestive Tract Morphogenesis Embryonic Camera-type Eye Morphogenesis Neuron Development Smooth Muscle Tissue Development Positive Regulation Of Epithelial Cell Proliferation Cartilage Development Maternal Process Involved In Female Pregnancy Camera-type Eye Photoreceptor Cell Fate Commitment Head Morphogenesis Somite Development Embryonic Skeletal Joint Development Epithelial Cell-cell Adhesion	Carbohydrate Metabolic Process Smoothened Signaling Pathway Neuroblast Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Skeletal System Morphogenesis Oxidation-reduction Process Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Hedgehog ligand biogenesis Processing-defective Hh variants abrogate ligand secretion Hh ligand biogenesis disease GPCR ligand binding Metabolic disorders of biological oxidation enzymes Ligand-receptor interactions Release of Hh-Np from the secreting cell Hedgehog 'on' state Signaling by Hedgehog Class B/2 (Secretin family receptors)	Hedgehog 'on' state Signaling by Hedgehog Ligand-receptor interactions
Drugs
Diseases
GWAS		Height ( 20881960 18391951 18391952 20189936)	Chronic obstructive pulmonary disease ( 22080838 19300482 20173748) Height ( 20881960 19343178 23563607 18391950 18391951 18391952 20397748) Pulmonary function ( 20010834 20010835 19300500) Pulmonary function (interaction) ( 23284291)
Protein-Protein Interactions		4 interactors: HHIP PTCH1 PTCH2 RHOD	3 interactors: DHH IHH SHH
Entrez ID		3549	64399
HPRD ID		02839	06937
Ensembl ID		ENSG00000163501
Uniprot IDs		Q14623	Q96QV1
PDB IDs		3K7G 3K7H 3K7I 3K7J 3N1F 3N1M 3N1O 3N1P	2WFT 2WFX 2WG3 2WG4 3HO3 3HO4 3HO5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Smoothened Signaling Pathway Dorsal/ventral Pattern Formation Regulation Of Signal Transduction Regulation Of Signaling Neural Plate Axis Specification Response To Chlorate Epithelium Development Negative Regulation Of Signal Transduction Branching Morphogenesis Of An Epithelial Tube Negative Regulation Of Signaling Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Epidermis Development Tissue Development Cell Proliferation Involved In Metanephros Development Epithelial Tube Morphogenesis Smoothened Signaling Pathway Involved In Dorsal/ventral Neural Tube Patterning Protein Targeting Tube Morphogenesis Cell Proliferation Involved In Kidney Development Keratinocyte Proliferation Pattern Specification Process Cellular Response To Cholesterol Signal Transduction Neural Plate Development Morphogenesis Of An Epithelium Cellular Response To Sterol Positive Regulation Of Cholesterol Efflux Negative Regulation Of Multicellular Organism Growth Signaling Positive Regulation Of Cholesterol Transport Mammary Gland Epithelial Cell Differentiation Cell Communication Response To Cholesterol Pharyngeal System Development Regulation Of Cholesterol Efflux Tissue Morphogenesis Tube Development Cell Proliferation Focal Adhesion Assembly Dorsal/ventral Neural Tube Patterning Cellular Response To Stimulus Regulation Of Cholesterol Transport Cell Differentiation Involved In Kidney Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Actin Cytoskeleton Reorganization Protein Targeting To Plasma Membrane Spinal Cord Motor Neuron Differentiation	Intein-mediated Protein Splicing Negative Regulation Of Alpha-beta T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Alpha-beta T Cell Activation Embryonic Digestive Tract Morphogenesis Regulation Of T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation Embryonic Digestive Tract Development Positive Regulation Of Mesenchymal Cell Proliferation Positive Regulation Of Alpha-beta T Cell Differentiation Negative Regulation Of Lymphocyte Differentiation Regulation Of Mesenchymal Cell Proliferation Patterning Of Blood Vessels Positive Regulation Of Smoothened Signaling Pathway Heart Looping Negative Regulation Of T Cell Proliferation Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Digestive Tract Morphogenesis Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Positive Regulation Of Stem Cell Proliferation Developmental Process Involved In Reproduction Negative Regulation Of Leukocyte Proliferation Neuron Fate Commitment Positive Regulation Of T Cell Differentiation Embryonic Heart Tube Development Embryonic Pattern Specification Positive Regulation Of Lymphocyte Differentiation Regulation Of Smoothened Signaling Pathway Cell Fate Specification Pancreas Development Somite Development Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Cell-cell Signaling Negative Regulation Of Homotypic Cell-cell Adhesion Determination Of Left/right Symmetry Regulation Of Stem Cell Proliferation Determination Of Bilateral Symmetry Smoothened Signaling Pathway Response To Estradiol Regulation Of T Cell Differentiation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Cell-cell Adhesion Digestive Tract Development Osteoblast Differentiation Regulation Of T Cell Proliferation Digestive System Development Negative Regulation Of Ureter Smooth Muscle Cell Differentiation
Tagcloud ?		absent consequence defective deficiency diminished elevated etiology finding gnrh hypogonadism hypogonadotropic idiopathic implicated individually irrespective kallmann ks lh matched melatonin metabolite nighttime nocturnal principle pulsatility recruited respective sulphatoxymelatonin unlikely	augmented beta1 branching bud dams dysmorphogenesis dysnephrogenesis hedgehog heightened hypothesised impairs kidneys kip1 localised maternal maturing mesenchyme metanephric morphogenesis nfkappab offspring pax2 progeny retardation shh sonic tubulointerstitial ub ureteric
Tagcloud (Difference) ?		absent consequence defective deficiency diminished elevated etiology finding gnrh hypogonadism hypogonadotropic idiopathic implicated individually irrespective kallmann ks lh matched melatonin metabolite nighttime nocturnal principle pulsatility recruited respective sulphatoxymelatonin unlikely	augmented beta1 branching bud dams dysmorphogenesis dysnephrogenesis hedgehog heightened hypothesised impairs kidneys kip1 localised maternal maturing mesenchyme metanephric morphogenesis nfkappab offspring pax2 progeny retardation shh sonic tubulointerstitial ub ureteric
Tagcloud (Intersection) ?