IGHA1 and RNF115

Number of citations of the paper that reports this interaction (PubMedID 22315970)
45

Data Source:
BioGRID (two hybrid)

		IGHA1	RNF115
Description		immunoglobulin heavy constant alpha 1	ring finger protein 115
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Immunoglobulin Complex Immunoglobulin Complex, Circulating Extracellular Exosome IgG Immunoglobulin Complex IgA Immunoglobulin Complex Monomeric IgA Immunoglobulin Complex Secretory IgA Immunoglobulin Complex Secretory Dimeric IgA Immunoglobulin Complex Blood Microparticle	Nucleus Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol
	Molecular Function	Antigen Binding Immunoglobulin Receptor Binding	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Adaptive Immune Response Immune System Process Glomerular Filtration Immune Response Complement Activation, Classical Pathway Antibacterial Humoral Response B Cell Receptor Signaling Pathway Positive Regulation Of Respiratory Burst	Protein Polyubiquitination Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Protein Ubiquitination Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination
Pathways			Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Composite immunoglobulin trait (IgA/IgG) ( 28628107) Composite immunoglobulin trait (IgA/IgM) ( 28628107)	Apolipoprotein A1 levels ( 32203549) Breast cancer ( 25751625 29059683) HDL cholesterol levels ( 32203549) Platelet distribution width ( 32888494)
Interacting Genes		3 interacting genes: FYN LYN RNF115	34 interacting genes: AKT1 APP ATN1 CDK10 CST3 DAZAP2 DOCK4 EGFR FOLR3 HRAS IGHA1 MAVS MDM2 MDM4 MFAP4 NFKBIA RAB7A RAD23A RPL18A STING1 TTR UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2N USP9X VCP ZNRD2
Entrez ID		3493	27246
HPRD ID			18328
Ensembl ID		ENSG00000211895	ENSG00000265491
Uniprot IDs			Q9Y4L5
PDB IDs
Enriched GO Terms of Interacting Partners?		Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Innate Immune Response-activating Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Lectin Immune Response-regulating Cell Surface Receptor Signaling Pathway Activation Of Innate Immune Response Ephrin Receptor Binding Immune Response-activating Signaling Pathway Negative Regulation Of Inflammatory Response To Antigenic Stimulus Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Innate Immune Response T Cell Costimulation Positive Regulation Of Defense Response Non-membrane Spanning Protein Tyrosine Kinase Activity Toll-like Receptor 4 Signaling Pathway Cell Surface Toll-like Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Negative Regulation Of Immune System Process Cell Surface Pattern Recognition Receptor Signaling Pathway Fc Receptor Signaling Pathway Scaffold Protein Binding Positive Regulation Of Immune Response Positive Regulation Of Protein Localization To Membrane Regulation Of Defense Response Response To Amino Acid Lymphocyte Proliferation Mononuclear Cell Proliferation Regulation Of Immune Response Cellular Response To Glycine Response To Singlet Oxygen Protein Tyrosine Kinase Activity Transmembrane Transporter Binding Leukocyte Proliferation Positive Regulation Of Immune System Process Regulation Of Calcium Ion Transmembrane Transport Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Neuron Projection Development Pattern Recognition Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Negative Regulation Of Inflammatory Response Response To Glycine Positive Regulation Of Oligodendrocyte Progenitor Proliferation Membrane Raft	Ubiquitin Conjugating Enzyme Activity Protein Modification By Small Protein Conjugation Protein Ubiquitination Post-translational Protein Modification Ubiquitin-protein Transferase Activity Protein Polyubiquitination Modification-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein K11-linked Ubiquitination Protein Modification Process Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Macromolecule Catabolic Process Nucleotide Binding Protein Metabolic Process Protein Monoubiquitination Protein Serine/threonine Kinase Binding Ubiquitin Protein Ligase Binding Positive Regulation Of Cell Cycle G1/S Phase Transition Protein-containing Complex Positive Regulation Of Mitotic Cell Cycle Proteolysis Positive Regulation Of Mitotic Cell Cycle Phase Transition ATP Binding Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Phase Transition Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Intracellular Signal Transduction Immune Response-activating Signaling Pathway Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Proteolysis Positive Regulation Of Intracellular Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Enzyme Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cilium Assembly Protein K63-linked Ubiquitination Regulation Of G1/S Transition Of Mitotic Cell Cycle Immune Response-regulating Signaling Pathway Regulation Of Intracellular Signal Transduction Transferase Activity Activation Of Immune Response Protein K6-linked Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Traversing Start Control Point Of Mitotic Cell Cycle
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