IGFBP4 and CTSD

Number of citations of the paper that reports this interaction (PubMedID 9275067)
0

Data Source:
HPRD (in vitro)

		IGFBP4	CTSD
Description		insulin like growth factor binding protein 4	cathepsin D
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Cytoplasm Lysosome Lysosomal Membrane Cytosol Endosome Membrane Extracellular Matrix Endosome Lumen Specific Granule Lumen Melanosome Lysosomal Lumen Membrane Raft Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Endopeptidase Activity Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity Aspartic-type Peptidase Activity
	Biological Process	MAPK Cascade Regulation Of Cell Growth Signal Transduction Regulation Of Glucose Metabolic Process Regulation Of Growth Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Autophagosome Assembly Proteolysis Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Insulin Receptor Recycling Lipoprotein Catabolic Process Positive Regulation Of Apoptotic Process Regulation Of Establishment Of Protein Localization Execution Phase Of Apoptosis Insulin Catabolic Process
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Insulin receptor recycling Estrogen-dependent gene expression
Drugs			S-Methylcysteine 1h-Benoximidazole-2-Carboxylic Acid 2-Morpholinoethylamine 5-Amino-6-cyclohexyl-4-hydroxy-2-isobutyl-hexanoic acid CYCLOHEXYLMETHYL-2,3-DIHYDROXY-5-METHYL-HEXYLAMIDE
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Height ( 23563607 31562340) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)	Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Logical memory (delayed recall) in mild cognitive impairment ( 29274321)
Interacting Genes		9 interacting genes: CTSD HK3 IGF1 IGF2 KDM1A MEX3A PAPPA SUV39H1 TF	25 interacting genes: APP BGLAP CCL21 CD4 CST3 CSTB CTSB FN1 HSPB2 IGF2R IGFBP3 IGFBP4 INS MAPK1 MAPT NEAT1 NLGN3 OGT PSAP SERPINA4 SHBG SLC2A4 SNCA SPRED2 TG
Entrez ID		3487	1509
HPRD ID		00900	00291
Ensembl ID		ENSG00000141753	ENSG00000117984
Uniprot IDs		P22692	P07339 V9HWI3
PDB IDs		1WQJ 2DSP 2DSQ 2DSR	1LYA 1LYB 1LYW 4OBZ 4OC6 4OD9
Enriched GO Terms of Interacting Partners?		Exocrine Pancreas Development Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Insulin Receptor Binding Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Epigenetic Programming Of Gene Expression Regulation Of Glycogen Metabolic Process Regulation Of Activated T Cell Proliferation Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Extracellular Region Positive Regulation Of Neural Precursor Cell Proliferation Epigenetic Regulation Of Gene Expression Negative Regulation Of Oocyte Development Platelet Alpha Granule Lumen Regulation Of Multicellular Organism Growth Regulation Of Developmental Growth Striated Muscle Cell Differentiation Aspartic-type Peptidase Activity Endopeptidase Activity Extracellular Space Intracellular Glucose Homeostasis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Trophectodermal Cell Proliferation Epithelial To Mesenchymal Transition Insulin Receptor Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Organ Growth Regulation Of Neural Precursor Cell Proliferation Mannokinase Activity Insulin-like Growth Factor Binding Protein Complex Positive Regulation Of T Cell Proliferation Muscle Cell Development Glycolate Metabolic Process Regulation Of Glucose Metabolic Process Muscle Cell Differentiation Mesenchymal Cell Differentiation ENoSc Complex Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ficolin-1-rich Granule Lumen Insulin Catabolic Process Insulin Receptor Recycling	Extracellular Space Extracellular Region Endoplasmic Reticulum Lumen Regulation Of Small Molecule Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Synaptic Transmission Insulin-like Growth Factor II Binding Regulation Of MAPK Cascade Cognition Regulation Of Protein Metabolic Process Protease Binding Insulin-like Growth Factor Binding Regulation Of Phosphorus Metabolic Process Learning Or Memory Type B Pancreatic Cell Proliferation Modulation Of Chemical Synaptic Transmission Positive Regulation Of Signal Transduction Regulation Of Lipid Metabolic Process Regulation Of Developmental Process Regulation Of Synaptic Plasticity Amyloid Fibril Formation Response To Cytokine Regulation Of Cellular Component Organization Microglial Cell Activation Response To Peptide Regulation Of Multicellular Organismal Process Regulation Of Glucose Metabolic Process Regulation Of Cell Communication Leukocyte Activation Involved In Inflammatory Response Regulation Of Signaling Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Negative Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Cell-cell Signaling Positive Regulation Of Intracellular Signal Transduction Peptidase Inhibitor Activity Main Axon Cellular Response To Oxygen-containing Compound Signaling Negative Regulation Of Protein Catabolic Process Ficolin-1-rich Granule Lumen Cell Communication Regulation Of Generation Of Precursor Metabolites And Energy Positive Regulation Of MAPK Cascade Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Proteolysis
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