IGFBP4 and TF

Number of citations of the paper that reports this interaction (PubMedID 11297622)
0

Data Source:
HPRD (in vitro)

		IGFBP4	TF
Description		insulin like growth factor binding protein 4	transferrin
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen	Extracellular Region Extracellular Space Endosome Early Endosome Late Endosome Endoplasmic Reticulum Lumen Plasma Membrane Clathrin-coated Pit Basal Plasma Membrane Cell Surface Endosome Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Vesicle Secretory Granule Lumen Basal Part Of Cell Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Blood Microparticle HFE-transferrin Receptor Complex
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Iron Ion Binding Protein Binding Ferrous Iron Binding Ferric Iron Binding Enzyme Binding Iron Chaperone Activity Transmembrane Transporter Binding Metal Ion Binding Transferrin Receptor Binding
	Biological Process	MAPK Cascade Regulation Of Cell Growth Signal Transduction Regulation Of Glucose Metabolic Process Regulation Of Growth Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	Monoatomic Ion Transport Iron Ion Transport Intracellular Iron Ion Homeostasis Cell Surface Receptor Signaling Pathway Response To Bacterium Antibacterial Humoral Response Osteoclast Differentiation Regulation Of Protein Stability Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Receptor-mediated Endocytosis Multicellular Organismal-level Iron Ion Homeostasis Cellular Response To Iron Ion Iron Ion Export Across Plasma Membrane
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation Iron uptake and transport Transferrin endocytosis and recycling
Drugs			Cisplatin Isoflurophate Aluminium Iron Zinc Manganese Copper Dichlorvos Zinc acetate Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Height ( 23563607 31562340) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)	Alcohol consumption (transferrin glycosylation) ( 21665994) HDL cholesterol levels ( 32203549) Hepcidin levels ( 21785125) Hereditary hemochromatosis-related traits (HFE mutation homozygotes) ( 25457201) Iron status biomarkers ( 21208937 21483845 25224454 19084217) Iron status biomarkers (iron levels) ( 28334935 33536631 25352340) Iron status biomarkers (total iron binding capacity) ( 33536631 28334935) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 33536631 25352340 28334935) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular hemoglobin concentration ( 29403010 32888494 27863252) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red blood cell count ( 32888494) Red cell distribution width ( 27863252 32888494)
Interacting Genes		9 interacting genes: CTSD HK3 IGF1 IGF2 KDM1A MEX3A PAPPA SUV39H1 TF	47 interacting genes: AQP9 CALR CANX CLDN5 CPLX4 CUBN DRD2 ELOVL4 ERGIC3 FAM209A FAM210B FKBP7 GJB1 GOLM1 GPR42 GPX8 GRB2 HSD17B13 HSP90AA1 IGF1 IGF2 IGFBP1 IGFBP2 IGFBP3 IGFBP4 IGFBP5 IGFBP6 LAMC3 LCOR LEUTX PGRMC2 RMDN3 RSPH1 SH3BP2 SLC10A6 SLC26A6 SLC35H1 SMAD3 SORT1 SPINT1 SYT2 TFR2 TFRC TIMELESS TMEM52B TUBB3 VKORC1
Entrez ID		3487	7018
HPRD ID		00900	01811
Ensembl ID		ENSG00000141753	ENSG00000091513
Uniprot IDs		P22692	A0PJA6 P02787 Q06AH7
PDB IDs		1WQJ 2DSP 2DSQ 2DSR	1A8E 1A8F 1B3E 1BP5 1BTJ 1D3K 1D4N 1DTG 1FQE 1FQF 1JQF 1N7W 1N7X 1N84 1OQG 1OQH 1RYO 1SUV 2HAU 2HAV 2O7U 2O84 3FGS 3QYT 3S9L 3S9M 3S9N 3SKP 3V83 3V89 3V8X 3VE1 4H0W 4X1B 4X1D 5DYH 5H52 5WTD 5X5P 5Y6K 6CTC 6D03 6D04 6D05 6JAS 6SOY 6SOZ 6UJ6 7FFM 7FFU 7Q1L 8BRC 9H49 9H4V
Enriched GO Terms of Interacting Partners?		Exocrine Pancreas Development Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Insulin Receptor Binding Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Epigenetic Programming Of Gene Expression Regulation Of Glycogen Metabolic Process Regulation Of Activated T Cell Proliferation Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Extracellular Region Positive Regulation Of Neural Precursor Cell Proliferation Epigenetic Regulation Of Gene Expression Negative Regulation Of Oocyte Development Platelet Alpha Granule Lumen Regulation Of Multicellular Organism Growth Regulation Of Developmental Growth Striated Muscle Cell Differentiation Aspartic-type Peptidase Activity Endopeptidase Activity Extracellular Space Intracellular Glucose Homeostasis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Trophectodermal Cell Proliferation Epithelial To Mesenchymal Transition Insulin Receptor Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Organ Growth Regulation Of Neural Precursor Cell Proliferation Mannokinase Activity Insulin-like Growth Factor Binding Protein Complex Positive Regulation Of T Cell Proliferation Muscle Cell Development Glycolate Metabolic Process Regulation Of Glucose Metabolic Process Muscle Cell Differentiation Mesenchymal Cell Differentiation ENoSc Complex Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ficolin-1-rich Granule Lumen Insulin Catabolic Process Insulin Receptor Recycling	Insulin-like Growth Factor II Binding Insulin-like Growth Factor Binding Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor I Binding Growth Factor Binding Endoplasmic Reticulum Lumen Insulin-like Growth Factor Binding Protein Complex Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Ternary Complex Type B Pancreatic Cell Proliferation Striated Muscle Cell Differentiation Osteoblast Differentiation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Growth Transferrin Receptor Activity Receptor-mediated Endocytosis Muscle Cell Differentiation Regulation Of Cell Growth Response To Estradiol Positive Regulation Of Activated T Cell Proliferation Insulin Receptor Signaling Pathway Fibronectin Binding Morphogenesis Of A Branching Structure Intracellular Chemical Homeostasis Response To Iron Ion Cellular Developmental Process Epithelial Cell Proliferation Regulation Of Glucose Metabolic Process Protein Binding Positive Regulation Of Cellular Component Organization Developmental Process Endocytosis Regulation Of Activated T Cell Proliferation Positive Regulation Of T Cell Proliferation HFE-transferrin Receptor Complex Carbohydrate Transmembrane Transport Polyol Transmembrane Transport Iron Ion Transport Carbohydrate Transport Cellular Homeostasis Branching Involved In Labyrinthine Layer Morphogenesis Exocrine Pancreas Development Positive Regulation Of Transport Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Cell Adhesion Transferrin Transport Brush Border Membrane Chemical Homeostasis Protein Folding In Endoplasmic Reticulum
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