IGFBP4 and MEX3A

Number of citations of the paper that reports this interaction (PubMedID 37433992)
35

Data Source:
BioGRID (affinity chromatography technology, unspecified method)

		IGFBP4	MEX3A
Description		insulin like growth factor binding protein 4	mex-3 RNA binding family member A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen	P-body Nucleus Cytoplasm Cytosol
	Molecular Function	Signaling Receptor Binding Protein Binding Insulin-like Growth Factor Binding Growth Factor Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding	Nucleic Acid Binding RNA Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	MAPK Cascade Regulation Of Cell Growth Signal Transduction Regulation Of Glucose Metabolic Process Regulation Of Growth Positive Regulation Of MAPK Cascade Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Type B Pancreatic Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Height ( 23563607 31562340) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042)	Adult body size ( 32376654) Metabolite levels ( 23823483)
Interacting Genes		9 interacting genes: CTSD HK3 IGF1 IGF2 KDM1A MEX3A PAPPA SUV39H1 TF	5 interacting genes: IGFBP4 LINC00839 TP53 UBE2D2 UBE2L3
Entrez ID		3487	92312
HPRD ID		00900	19250
Ensembl ID		ENSG00000141753	ENSG00000254726
Uniprot IDs		P22692	A1L020
PDB IDs		1WQJ 2DSP 2DSQ 2DSR
Enriched GO Terms of Interacting Partners?		Exocrine Pancreas Development Insulin-like Growth Factor Receptor Binding Transmembrane Receptor Protein Tyrosine Kinase Activator Activity Positive Regulation Of Glycogen Biosynthetic Process Insulin Receptor Binding Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Regulation Of Glycogen Biosynthetic Process Epigenetic Programming Of Gene Expression Regulation Of Glycogen Metabolic Process Regulation Of Activated T Cell Proliferation Positive Regulation Of Glucose Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Organ Growth Extracellular Region Positive Regulation Of Neural Precursor Cell Proliferation Epigenetic Regulation Of Gene Expression Negative Regulation Of Oocyte Development Platelet Alpha Granule Lumen Regulation Of Multicellular Organism Growth Regulation Of Developmental Growth Striated Muscle Cell Differentiation Aspartic-type Peptidase Activity Endopeptidase Activity Extracellular Space Intracellular Glucose Homeostasis Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Trophectodermal Cell Proliferation Epithelial To Mesenchymal Transition Insulin Receptor Signaling Pathway Telomeric Repeat-containing RNA Binding FAD-dependent H3K4me/H3K4me3 Demethylase Activity Regulation Of Organ Growth Regulation Of Neural Precursor Cell Proliferation Mannokinase Activity Insulin-like Growth Factor Binding Protein Complex Positive Regulation Of T Cell Proliferation Muscle Cell Development Glycolate Metabolic Process Regulation Of Glucose Metabolic Process Muscle Cell Differentiation Mesenchymal Cell Differentiation ENoSc Complex Iron Chaperone Activity Iron Ion Export Across Plasma Membrane Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ficolin-1-rich Granule Lumen Insulin Catabolic Process Insulin Receptor Recycling	Ubiquitin Conjugating Enzyme Activity Regulation Of Glucose Metabolic Process Cell Population Proliferation Oligodendrocyte Apoptotic Process Negative Regulation Of Fermentation Intrinsic Apoptotic Signaling Pathway In Response To Hypoxia Histone Deacetylase Regulator Activity Negative Regulation Of Pentose-phosphate Shunt Positive Regulation Of Thymocyte Apoptotic Process Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Response To Actinomycin D T Cell Proliferation Involved In Immune Response Negative Regulation Of Helicase Activity Oxidative Stress-induced Premature Senescence Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate Negative Regulation Of G1 To G0 Transition Regulation Of G1 To G0 Transition Glucose Catabolic Process To Lactate Via Pyruvate Glial Cell Apoptotic Process Cellular Response To UV-C Germ Cell Nucleus Cellular Response To Actinomycin D ATP-dependent DNA/DNA Annealing Activity B Cell Lineage Commitment Regulation Of Pentose-phosphate Shunt Mitochondrial DNA Repair Bone Marrow Development Stress-induced Premature Senescence Ubiquitin-protein Transferase Activity Insulin-like Growth Factor II Binding Regulation Of NADP Metabolic Process Negative Regulation Of MiRNA Processing Insulin-like Growth Factor I Binding Insulin-like Growth Factor Binding Positive Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Small Molecule Metabolic Process Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Cellular Senescence Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of MiRNA Processing Regulation Of Thymocyte Apoptotic Process Ubiquitin Protein Ligase Binding Thymocyte Apoptotic Process Negative Regulation Of ATP-dependent Activity ER Overload Response Mitotic G1 DNA Damage Checkpoint Signaling MDM2/MDM4 Family Protein Binding TFIID-class Transcription Factor Complex Binding Replicative Senescence Positive Regulation Of Programmed Necrotic Cell Death
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