IGF2R and CREG1

Number of citations of the paper that reports this interaction (PMID 12934103)
9

Data Source:
HPRD (in vitro)

		IGF2R	CREG1
Gene Name		insulin-like growth factor 2 receptor	cellular repressor of E1A-stimulated genes 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Nuclear Envelope Lumen Lysosomal Membrane Endosome Late Endosome Trans-Golgi Network Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Membrane Clathrin Coat Endocytic Vesicle Trans-Golgi Network Transport Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Transcription Factor Complex Extracellular Vesicular Exosome
	Molecular Function	Glycoprotein Binding G-protein Alpha-subunit Binding Retinoic Acid Binding Receptor Activity G-protein Coupled Receptor Activity Insulin-like Growth Factor-activated Receptor Activity Transporter Activity Protein Binding Mannose Binding Enzyme Binding Insulin-like Growth Factor II Binding Identical Protein Binding Phosphoprotein Binding	Transcription Corepressor Activity Transcription Factor Binding FMN Binding Oxidoreductase Activity
	Biological Process	Liver Development Receptor-mediated Endocytosis Signal Transduction G-protein Coupled Receptor Signaling Pathway Spermatogenesis Post-embryonic Development Organ Regeneration Response To Retinoic Acid Positive Regulation Of Apoptotic Process Insulin-like Growth Factor Receptor Signaling Pathway	Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Cell Proliferation Regulation Of Growth Oxidation-reduction Process Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Golgi Associated Vesicle Biogenesis trans-Golgi Network Vesicle Budding Clathrin derived vesicle budding
Drugs
Diseases
GWAS		Brain lesion load ( 19010793)
Protein-Protein Interactions		14 interactors: AGA ATXN1 CREG1 CSNK2A1 CTSD GGA1 GGA2 GGA3 GZMB IGF2 PACS1 PLAU PLAUR PLIN3	6 interactors: CAPN1 IGF2R RB1 RBL1 RBL2 TBP
Entrez ID		3482	8804
HPRD ID		00928	09897
Ensembl ID		ENSG00000197081	ENSG00000143162
Uniprot IDs		P11717	O75629
PDB IDs		1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2V5N 2V5O 2V5P	1XHN
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Fibrinolysis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Blood Coagulation Establishment Of Localization In Cell Negative Regulation Of Coagulation Urokinase Plasminogen Activator Signaling Pathway Negative Regulation Of Wound Healing Intracellular Transport Regulation Of Protein Catabolic Process Intracellular Protein Transport Cellular Localization Regulation Of Blood Coagulation Blood Coagulation Regulation Of Smooth Muscle Cell-matrix Adhesion Hemostasis Regulation Of Receptor Activity Protein Deglycosylation Insulin Receptor Signaling Pathway Via Phosphatidylinositol 3-kinase Regulation Of Mitotic Nuclear Division Regulation Of Wound Healing Positive Regulation Of Glycogen (starch) Synthase Activity Granzyme-mediated Apoptotic Signaling Pathway	Regulation Of Lipid Kinase Activity Regulation Of Lipid Metabolic Process Viral Process Chromatin Modification Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Chromatin Organization Mitotic Cell Cycle Regulation Of Kinase Activity Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Transcription Initiation From RNA Polymerase II Promoter Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Regulation Of Cell Cycle Transcription, DNA-templated Attachment Of Mitotic Spindle Microtubules To Kinetochore DNA-templated Transcription, Initiation RNA Biosynthetic Process Chromosome Organization Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Protein Localization To Chromosome, Centromeric Region Attachment Of Spindle Microtubules To Kinetochore Regulation Of Phosphorylation Positive Regulation Of Macrophage Differentiation Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Biosynthetic Process Cell Cycle Receptor Catabolic Process Mitotic Sister Chromatid Cohesion Enucleate Erythrocyte Differentiation RNA Metabolic Process Chromatin Silencing At RDNA Positive Regulation Of Chromosome Segregation Regulation Of Phosphorus Metabolic Process Regulation Of Sister Chromatid Cohesion Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Hepatocyte Apoptotic Process Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Gene Expression Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process
Tagcloud ?		acting base box constitutes copies differentially discrimination distinguish dmr dmrs embryo encodes erased establishment germ gonads imprint imprinted imprinting includes maintained mark methylated methylation novo pair parent paternal phenomenon	abundances agt ahr amongst aryl came car3 coherency constitutive contrasting ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic
Tagcloud (Difference) ?		acting base box constitutes copies differentially discrimination distinguish dmr dmrs embryo encodes erased establishment germ gonads imprint imprinted imprinting includes maintained mark methylated methylation novo pair parent paternal phenomenon	abundances agt ahr amongst aryl came car3 coherency constitutive contrasting ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences kcnj8 me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic
Tagcloud (Intersection) ?