IGF2R and PACS1

Number of citations of the paper that reports this interaction (PubMedID 11331585)
42

Data Source:
HPRD (in vivo, in vitro)

		IGF2R	PACS1
Description		insulin like growth factor 2 receptor	phosphofurin acidic cluster sorting protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Nucleus Nuclear Envelope Lumen Endosome Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Focal Adhesion Cell Surface Endosome Membrane Endomembrane System Membrane Clathrin Coat Transport Vesicle Endocytic Vesicle Trans-Golgi Network Transport Vesicle Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Golgi Apparatus Cytosol COPI-coated Vesicle
	Molecular Function	G-protein Alpha-subunit Binding Retinoic Acid Binding Insulin-like Growth Factor Receptor Activity Protein Binding Insulin-like Growth Factor Binding D-mannose Binding Enzyme Binding Insulin-like Growth Factor II Binding Signaling Receptor Activity Identical Protein Binding Phosphoprotein Binding Retromer Complex Binding	Protein Binding Transmembrane Transporter Binding
	Biological Process	Liver Development Receptor-mediated Endocytosis Lysosomal Transport Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Post-embryonic Development Animal Organ Regeneration Response To Retinoic Acid Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Host-mediated Activation Of Viral Process Insulin-like Growth Factor Receptor Signaling Pathway Response To Tetrachloromethane	Lymphocyte Homeostasis Protein Localization To Golgi Apparatus Protein Localization To Plasma Membrane
Pathways		Golgi Associated Vesicle Biogenesis Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Nef mediated downregulation of MHC class I complex cell surface expression
Drugs		Mecasermin alpha-D-mannose 6-phosphate Cerliponase alfa Mecasermin rinfabate Avalglucosidase alfa
Diseases		Hepatocellular carcinoma
GWAS		Apolipoprotein B levels ( 32203549) Blood protein levels ( 30072576) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain lesion load ( 19010793) Coronary artery disease ( 29212778) LDL cholesterol levels ( 32203549) Lipoprotein (a) levels ( 26377243) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Periodontitis (CDC/AAP) ( 24024966) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748)	Acne (severe) ( 24927181) Bipolar disorder ( 21926972 31043756 33263727 34002096) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Electroencephalogram traits ( 25387704) Hip circumference adjusted for BMI ( 34021172) Immature fraction of reticulocytes ( 32888494) Obesity (early onset extreme) ( 23563609) Serum uric acid levels ( 32514006) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		14 interacting genes: AGA ATXN1 CREG1 CSNK2A1 CTSD GGA1 GGA2 GGA3 GZMB IGF2 PACS1 PLAU PLAUR PLIN3	10 interacting genes: CLCN7 CSNK2A1 FURIN GGA3 IGF2R JUN PKD2 PPP2CA PPP2CB VAMP4
Entrez ID		3482	55690
HPRD ID		00928	06320
Ensembl ID		ENSG00000197081	ENSG00000175115
Uniprot IDs		P11717	Q6VY07
PDB IDs		1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y 6P8I 6V02 6Z30 6Z31 6Z32 8AFZ
Enriched GO Terms of Interacting Partners?		Urokinase Plasminogen Activator Signaling Pathway Endosome Membrane Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Protein Localization To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Lysosome Serine-type Endopeptidase Complex Protein Complex Involved In Cell-matrix Adhesion Protein Localization To Cell Periphery Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Ubiquitin Binding Protein Localization To Membrane Phosphatidylinositol Binding Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport To The Plasma Membrane Execution Phase Of Apoptosis Endosome Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Peptidase Activity Trans-Golgi Network Early Endosome Membrane Establishment Of Protein Localization To Membrane Positive Regulation Of Protein Catabolic Process Extracellular Region Extracellular Space Cellular Localization Protein Targeting To Vacuole Intracellular Protein Transport Regulation Of Protein Metabolic Process Localization Within Membrane Urokinase Plasminogen Activator Receptor Activity Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Vacuole Protein Transport Regulation Of Protein Maturation Protein Catabolic Process N4-(beta-N-acetylglucosaminyl)-L-asparaginase Activity Protein Localization To Organelle Aspartic-type Peptidase Activity Cytolytic Granule Lumen Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Hemostasis Regulation Of Blood Coagulation	Response To Metal Ion Golgi To Plasma Membrane Transport Trans-Golgi Network Post-Golgi Vesicle-mediated Transport Trans-Golgi Network Transport Vesicle Liver Development Transforming Growth Factor Beta Receptor Signaling Pathway FAR/SIN/STRIPAK Complex Protein Phosphatase Type 2A Complex Response To Lead Ion Negative Regulation Of DNA Repair Vacuolar Transport Negative Regulation Of Double-strand Break Repair Vesicle-mediated Transport To The Plasma Membrane Response To Calcium Ion Host-mediated Activation Of Viral Process Phosphoprotein Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Nerve Growth Factor Production Dibasic Protein Processing Zymogen Inhibition Transmembrane Transporter Binding Cellular Response To Fluid Shear Stress Metanephric Cortical Collecting Duct Development Response To Fluid Shear Stress Metanephric Cortex Development Metanephric Distal Tubule Development RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Golgi To Plasma Membrane Protein Transport Homocarnosine Synthase Activity Carnosine Synthase Activity Carnosine Biosynthetic Process Kinesin I Complex Tau Protein Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Chloride:proton Antiporter Activity Lysosome Positive Regulation Of Protein Catabolic Process Protein Targeting To Vacuole Rab GDP-dissociation Inhibitor Activity Leading Edge Cell Differentiation Golgi Apparatus Subcompartment Regulation Of Nerve Growth Factor Production Negative Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Peptidase Activity Nerve Growth Factor Production Negative Regulation Of Neurotrophin Production Polycystin Complex Metanephric Smooth Muscle Tissue Development
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