IGF2R and PLAU

Number of citations: 68 (PubMedID 9566979)
Data Source: HPRD (in vitro)

		IGF2R	PLAU
Name		insulin like growth factor 2 receptor	plasminogen activator, urokinase
Structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Nucleus Nuclear Envelope Lumen Endosome Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Focal Adhesion Cell Surface Endosome Membrane Endomembrane System Membrane Clathrin Coat Transport Vesicle Endocytic Vesicle Trans-Golgi Network Transport Vesicle Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Serine Protease Inhibitor Complex Protein Complex Involved In Cell-matrix Adhesion Serine-type Endopeptidase Complex
	Molecular Function	G-protein Alpha-subunit Binding Retinoic Acid Binding Insulin-like Growth Factor Receptor Activity Protein Binding Insulin-like Growth Factor Binding D-mannose Binding Enzyme Binding Insulin-like Growth Factor II Binding Signaling Receptor Activity Identical Protein Binding Phosphoprotein Binding Retromer Complex Binding	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Receptor Ligand Activity
	Biological Process	Liver Development Receptor-mediated Endocytosis Lysosomal Transport Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Post-embryonic Development Animal Organ Regeneration Response To Retinoic Acid Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Host-mediated Activation Of Viral Process Insulin-like Growth Factor Receptor Signaling Pathway Response To Tetrachloromethane	Response To Hypoxia Proteolysis Chemotaxis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of Plasminogen Activation Negative Regulation Of Plasminogen Activation Smooth Muscle Cell Migration Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Plasminogen Activation Regulation Of Cell Adhesion Mediated By Integrin Urokinase Plasminogen Activator Signaling Pathway Regulation Of Cell Population Proliferation Fibrinolysis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Fibrinolysis Negative Regulation Of Fibrinolysis Regulation Of Wound Healing Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Integrin-mediated Signaling Pathway
Pathways		Golgi Associated Vesicle Biogenesis Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Neutrophil degranulation Dissolution of Fibrin Clot
Drugs		Mecasermin alpha-D-mannose 6-phosphate Cerliponase alfa Mecasermin rinfabate Avalglucosidase alfa	Amiloride 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine CRA_10655 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine 2-Amino-1H-benzimidazol-5-ol N-(1-adamantyl)-N'-(4-guanidinobenzyl)urea 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine Fibrinolysin 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine (2R)-1-(2,6-dimethylphenoxy)propan-2-amine 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
Diseases		Hepatocellular carcinoma	None
GWAS		Apolipoprotein B levels ( 32203549 ) Blood protein levels ( 30072576 ) Body mass index ( 26426971 ) Body mass index (age>50) ( 26426971 ) Body mass index x sex x age interaction (4df test) ( 26426971 ) Brain lesion load ( 19010793 ) Coronary artery disease ( 29212778 ) LDL cholesterol levels ( 32203549 ) Lipoprotein (a) levels ( 26377243 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Periodontitis (CDC/AAP) ( 24024966 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 ) Serum metabolite levels ( 33031748 )	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Crohn's disease ( 28067908 )
Novel Interactors		None recorded	1 novel interactors: SFTPD
Interacting Genes		14 interacting genes: AGA ATXN1 CREG1 CSNK2A1 CTSD GGA1 GGA2 GGA3 GZMB IGF2 PACS1 PLAU PLAUR PLIN3	25 interacting genes: ADAM28 ALAS1 BTK CEBPG CTSB CTSL ELAVL1 F2 HGF IGF2R KAT8 LRP2 MYC NID1 PDGFC PLAT PLAUR PLG SCAMP5 SERPINA5 SERPINB2 SERPINB6 SERPINE1 SERPINF2 ST14
Entrez ID		3482	5328
HPRD ID		00928	01883
Ensembl ID		ENSG00000197081	ENSG00000122861
Uniprot IDs		P11717	B4DNJ4 E7ET40 P00749 Q59GZ8
PDB IDs		1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y 6P8I 6V02 6Z30 6Z31 6Z32 8AFZ	1C5W 1C5X 1C5Y 1C5Z 1EJN 1F5K 1F5L 1F92 1FV9 1GI7 1GI8 1GI9 1GJ7 1GJ8 1GJ9 1GJA 1GJB 1GJC 1GJD 1KDU 1LMW 1O3P 1O5A 1O5B 1O5C 1OWD 1OWE 1OWH 1OWI 1OWJ 1OWK 1SC8 1SQA 1SQO 1SQT 1U6Q 1URK 1VJ9 1VJA 1W0Z 1W10 1W11 1W12 1W13 1W14 2FD6 2I9A 2I9B 2NWN 2O8T 2O8U 2O8W 2R2W 2VIN 2VIO 2VIP 2VIQ 2VIV 2VIW 2VNT 3BT1 3BT2 3IG6 3KGP 3KHV 3KID 3M61 3MHW 3MWI 3OX7 3OY5 3OY6 3PB1 3QN7 3U73 4DVA 4DW2 4FU7 4FU8 4FU9 4FUB 4FUC 4FUD 4FUE 4FUF 4FUG 4FUH 4FUI 4FUJ 4GLY 4H42 4JK5 4JK6 4K24 4MNV 4MNW 4MNX 4MNY 4OS1 4OS2 4OS4 4OS5 4OS6 4OS7 4X0W 4X1N 4X1P 4X1Q 4X1R 4X1S 4XSK 4ZHL 4ZHM 4ZKN 4ZKO 4ZKR 4ZKS 5HGG 5WXF 5WXO 5WXP 5WXQ 5WXR 5WXS 5WXT 5XG4 5YC6 5YC7 5Z1C 5ZA7 5ZA8 5ZA9 5ZAE 5ZAF 5ZAG 5ZAH 5ZAJ 5ZC5 6AG2 6AG3 6AG7 6AG9 6JYP 6JYQ 6L04 6L05 6NMB 6XVD 7DZD 7VM4 7VM5 7VM6 7VM7 7ZRR 7ZRT
GO Terms Enriched among Interactors		Urokinase Plasminogen Activator Signaling Pathway Endosome Membrane Protein Localization To Cell Surface Golgi To Plasma Membrane Protein Transport Protein Localization To Plasma Membrane Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Lysosome Serine-type Endopeptidase Complex Protein Complex Involved In Cell-matrix Adhesion Protein Localization To Cell Periphery Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Ubiquitin Binding Protein Localization To Membrane Phosphatidylinositol Binding Post-Golgi Vesicle-mediated Transport Vesicle-mediated Transport To The Plasma Membrane Execution Phase Of Apoptosis Endosome Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Peptidase Activity Trans-Golgi Network Early Endosome Membrane Establishment Of Protein Localization To Membrane Positive Regulation Of Protein Catabolic Process Extracellular Region Extracellular Space Cellular Localization Protein Targeting To Vacuole Intracellular Protein Transport Regulation Of Protein Metabolic Process Localization Within Membrane Urokinase Plasminogen Activator Receptor Activity Regulation Of Protein Processing Negative Regulation Of Protein Metabolic Process Establishment Of Protein Localization To Vacuole Protein Transport Regulation Of Protein Maturation Protein Catabolic Process N4-(beta-N-acetylglucosaminyl)-L-asparaginase Activity Protein Localization To Organelle Aspartic-type Peptidase Activity Cytolytic Granule Lumen Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Regulation Of Hemostasis Regulation Of Blood Coagulation	Regulation Of Fibrinolysis Fibrinolysis Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Extracellular Matrix Extracellular Space Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Wound Healing Extracellular Region Regulation Of Response To Wounding Regulation Of Plasminogen Activation Serine Protease Inhibitor Complex Positive Regulation Of Wound Healing Regulation Of Multicellular Organismal Process Negative Regulation Of Plasminogen Activation Regulation Of Body Fluid Levels Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Multicellular Organismal Process Protease Binding Peptidase Inhibitor Activity External Side Of Plasma Membrane Proteoglycan Binding Regulation Of Protein Processing Regulation Of Cytokine Production Regulation Of Protein Maturation Extracellular Exosome Platelet Alpha Granule Lumen Serine-type Endopeptidase Activity Negative Regulation Of Gene Expression Peptidase Activity Negative Regulation Of Protein Processing Developmental Process Negative Regulation Of Protein Maturation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Cytokine Production Endopeptidase Activity Peptidase Inhibitor Complex Trans-synaptic Signaling By BDNF Blood Coagulation Coagulation Hemostasis Endolysosome Lumen Signaling Receptor Binding