MACC1 and FASLG

Number of citations of the paper that reports this interaction (PMID 19807924)
2

Data Source:
BioGRID (unspecified method)

		MACC1	FASLG
Gene Name		metastasis associated in colon cancer 1	Fas ligand (TNF superfamily, member 6)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Membrane-bounded Vesicle Lumen Extracellular Vesicular Exosome
	Molecular Function	Growth Factor Activity	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Division	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) ( 23648065)	Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)
Protein-Protein Interactions		1 interactors: FASLG	74 interactors: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NL OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1
Entrez ID		346389	356
HPRD ID		12381	00610
Ensembl ID		ENSG00000183742	ENSG00000117560
Uniprot IDs		Q6ZN28	P48023 Q53ZZ1
PDB IDs			1BZI
Enriched GO Terms of Interacting Partners?		Endosomal Lumen Acidification Retinal Cell Programmed Cell Death Necroptotic Signaling Pathway Cellular Chloride Ion Homeostasis Inflammatory Cell Apoptotic Process Chloride Ion Homeostasis Positive Regulation Of Endothelial Cell Apoptotic Process T Cell Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Intracellular PH Reduction PH Reduction Positive Regulation Of ERBB Signaling Pathway Endosome Organization Necroptotic Process Regulation Of Endothelial Cell Apoptotic Process Developmental Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Intracellular PH Programmed Necrotic Cell Death Anion Homeostasis Regulation Of Cellular PH Necrotic Cell Death Positive Regulation Of Neuron Apoptotic Process Regulation Of PH Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Neuron Death Regulation Of ERBB Signaling Pathway Negative Regulation Of Angiogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Zymogen Activation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Endopeptidase Activity Positive Regulation Of Peptidase Activity Eye Morphogenesis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Cysteine-type Endopeptidase Activity Regulation Of Angiogenesis Regulation Of I-kappaB Kinase/NF-kappaB Signaling Protein Processing Regulation Of Neuron Apoptotic Process Regulation Of Neuron Death Positive Regulation Of Proteolysis Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin	Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune System Process Regulation Of Immune System Process Regulation Of Cell Activation Endocytosis Positive Regulation Of Cell Activation Immune Response Regulation Of Cellular Process T Cell Receptor Signaling Pathway Axon Guidance Regulation Of Lymphocyte Activation Signal Transduction Locomotion Positive Regulation Of T Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Defense Response Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-cell Adhesion Signaling Regulation Of Signal Transduction Cell Communication Chemotaxis T Cell Costimulation Axonogenesis Response To External Stimulus Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Axon Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Vesicle-mediated Transport Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway
Tagcloud ?		ability altered blotting boyden cadherin cck cdk2 cervical chamber closely colon cycle cytometry downregulated downregulation evoked expressions invasion kit mmp p21 siha sirna suppressed transfected transfection untreated western	casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable
Tagcloud (Difference) ?		ability altered blotting boyden cadherin cck cdk2 cervical chamber closely colon cycle cytometry downregulated downregulation evoked expressions invasion kit mmp p21 siha sirna suppressed transfected transfection untreated western	casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable
Tagcloud (Intersection) ?