IFNG

Description		interferon gamma
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Cytokine Activity Type II Interferon Receptor Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Cytokine Production Adaptive Immune Response Macrophage Activation Involved In Immune Response Positive Regulation Of T Cell Cytokine Production Apoptotic Process Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Response To Virus Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Macrophage Differentiation Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Interleukin-2-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Activation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of Neurogenesis Regulation Of Insulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Transport Defense Response To Virus Type II Interferon-mediated Signaling Pathway Positive Regulation Of Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Deacetylation Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Neuroinflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Cellular Respiration Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Core Promoter Binding Positive Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation IFNG signaling activates MAPKs Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)
Drugs		Olsalazine Glucosamine VIR201 Fontolizumab Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Emapalumab
Diseases		Graft-versus-host disease Allograft rejection
GWAS		Alopecia areata ( 25608926) Anti-saccade response ( 29064472) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 19122664 20228799 21297633)
Novel Interacting Genes		1 novel interacting genes: CDK4
Interacting Genes		5 interacting genes: IFNGR1 IFNGR2 PDIA3 STAT6 TNF
Entrez ID		3458
HPRD ID		00957
Ensembl ID		ENSG00000111537
Uniprot IDs		P01579
PDB IDs		1EKU 1FG9 1FYH 1HIG 3BES 6E3K 6E3L
Enriched GO Terms of Interacting Partners?		Type II Interferon Receptor Activity Leukocyte Activation Involved In Inflammatory Response Microglial Cell Activation Macrophage Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Type III Interferon-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Myeloid Leukocyte Activation Type II Interferon-mediated Signaling Pathway Leukocyte Activation Astrocyte Activation Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Amide Metabolic Process Immune System Process Positive Regulation Of Immunoglobulin Mediated Immune Response Defense Response To Virus Regulation Of Amyloid-beta Formation Cell Surface Receptor Signaling Pathway Cytokine Receptor Activity Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Immunoglobulin Production Response To Virus Signal Transduction Interferon-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Virus Regulation Of Amide Metabolic Process Regulation Of Immunoglobulin Production Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Response To External Biotic Stimulus Response To Peptide Response To Cytokine Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Extrinsic Apoptotic Signaling Pathway Tapasin-ERp57 Complex Defense Response Mammary Gland Morphogenesis Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus
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