IFNG and PDIA3

Number of citations of the paper that reports this interaction (PMID 8974399)
62

Data Source:
HPRD (in vivo)

		IFNG	PDIA3
Gene Name		interferon, gamma	protein disulfide isomerase family A, member 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Cell Surface Melanosome Extracellular Vesicular Exosome
	Molecular Function	Cytokine Activity Interferon-gamma Receptor Binding	Protein Disulfide Isomerase Activity Cysteine-type Endopeptidase Activity Phospholipase C Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter Neutrophil Apoptotic Process Regulation Of The Force Of Heart Contraction Positive Regulation Of Mesenchymal Cell Proliferation Adaptive Immune Response CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Apoptotic Process Movement Of Cell Or Subcellular Component Humoral Immune Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Neutrophil Chemotaxis Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Myelination Positive Regulation Of Synaptic Transmission, Cholinergic Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of T Cell Proliferation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Insulin Secretion Sensory Perception Of Mechanical Stimulus Positive Regulation Of Membrane Protein Ectodomain Proteolysis Defense Response To Virus Positive Regulation Of Killing Of Cells Of Other Organism Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Fructose 1,6-bisphosphate 1-phosphatase Activity Positive Regulation Of Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-18 Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Extrinsic Apoptotic Signaling Pathway Regulation Of Neuronal Action Potential Positive Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Regulation Of Hepatocyte Proliferation	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Protein Folding Proteolysis Protein Import Into Nucleus Protein Retention In ER Lumen Signal Transduction Protein N-linked Glycosylation Via Asparagine Response To Endoplasmic Reticulum Stress Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Post-translational Protein Modification Cellular Protein Metabolic Process Cell Redox Homeostasis Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling	Diseases of glycosylation Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Antigen Presentation: Folding, assembly and peptide loading of class I MHC Defective MOGS causes MOGS-CDG (CDG-2b) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MAN1B1 causes MRT15 Class I MHC mediated antigen processing & presentation N-glycan trimming in the ER and Calnexin/Calreticulin cycle Defective ALG11 causes ALG11-CDG (CDG-1p) Defective ALG2 causes ALG2-CDG (CDG-1i) Post-translational protein modification Defective ALG3 causes ALG3-CDG (CDG-1d) Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective ALG6 causes ALG6-CDG (CDG-1c) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective ALG12 causes ALG12-CDG (CDG-1g) Antigen processing-Cross presentation ER-Phagosome pathway Diseases associated with N-glycosylation of proteins Adaptive Immune System Calnexin/calreticulin cycle
Drugs		Olsalazine Glucosamine
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 20228799 21297633 19122664)
Protein-Protein Interactions		5 interactors: IFNGR1 IFNGR2 PDIA3 STAT6 TNF	15 interactors: APP BACE1 CALR CANX ERO1L ERP27 GYPC HLA-A IFNG MDM2 SLC12A3 SLC2A1 STAT3 SUMO4 TAP1
Entrez ID		3458	2923
HPRD ID		00957	03625
Ensembl ID		ENSG00000111537	ENSG00000167004
Uniprot IDs		P01579	G5EA52 P30101
PDB IDs		1EKU 1FG9 1FYH 1HIG 3BES	2ALB 2DMM 2H8L 3F8U
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Immune System Process Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Immune Response Response To Virus Positive Regulation Of Immunoglobulin Mediated Immune Response Immune Response Regulation Of Immune System Process Defense Response Response To Stress Epithelial Cell Proliferation Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Branching Involved In Lung Morphogenesis Negative Regulation Of L-glutamate Transport Protein Import Into Nucleus Negative Regulation Of Immune Response Response To Other Organism Nuclear Import Interferon-gamma-mediated Signaling Pathway Response To Biotic Stimulus Positive Regulation Of Adaptive Immune Response Innate Immune Response Cellular Response To Interferon-gamma T-helper 1 Cell Lineage Commitment Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Response To Gold Nanoparticle Gland Morphogenesis Protein Import Response To Interferon-gamma Protein Localization To Nucleus Signal Transduction Response To Organic Substance Positive Regulation Of Interleukin-18 Production Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Mononuclear Cell Migration Sequestering Of Triglyceride Regulation Of Adaptive Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Signaling Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Interleukin-4-mediated Signaling Pathway Positive Regulation Of Isotype Switching To IgE Isotypes Cell Communication	Antigen Processing And Presentation Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Protein Localization To Nucleus Chaperone-mediated Protein Folding Antigen Processing And Presentation Of Peptide Antigen Cellular Localization Response To Stress Protein Maturation By Protein Folding Endoplasmic Reticulum Unfolded Protein Response Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Cellular Response To Unfolded Protein Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I Cytoplasmic Transport Negative Regulation Of Cell Development ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Antigen Processing And Presentation Of Endogenous Antigen Establishment Of Localization In Cell Defense Response Homeostatic Process Response To Unfolded Protein Immune System Process Chemical Homeostasis Establishment Of Protein Localization Intracellular Transport Response To Endoplasmic Reticulum Stress Response To Drug Protein Localization To Organelle Viral Process Intracellular Receptor Signaling Pathway Response To Estrogen Protein Maturation Transport Cellular Response To Organic Substance Protein Localization Nucleocytoplasmic Transport Nuclear Transport Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein Folding Regulation Of Neurogenesis Positive Regulation Of Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Negative Regulation Of Neurogenesis Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Negative Regulation Of Cell Differentiation Cellular Protein Localization Calcium Ion Homeostasis Peptide Antigen Assembly With MHC Class I Protein Complex
Tagcloud ?		30min ancestry asks asleep habitual ifngr1 il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia2 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization
Tagcloud (Difference) ?		30min ancestry asks asleep habitual ifngr1 il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	calnexin calreticulin catalysed desirable disulphide erdj5 erp44 erp57 erp72 grp78 immunocytochemical immunogens immunolocalization infective isomerase orthologues pdia10 pdia19 pdia2 pdia4 pdis spiralis thioredoxin tmx1 tmx2 tmx3 trichinella trimerization
Tagcloud (Intersection) ?