IFNG and IFNGR2

Number of citations of the paper that reports this interaction (PMID 7673114)
21

Data Source:
BioGRID (pull down)
HPRD (in vivo)

		IFNG	IFNGR2
Gene Name		interferon, gamma	interferon gamma receptor 2 (interferon gamma transducer 1)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space External Side Of Plasma Membrane	Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interferon-gamma Receptor Binding	Cytokine Receptor Activity Interferon-gamma Receptor Activity
	Biological Process	Protein Import Into Nucleus, Translocation Negative Regulation Of Transcription From RNA Polymerase II Promoter Neutrophil Apoptotic Process Regulation Of The Force Of Heart Contraction Positive Regulation Of Mesenchymal Cell Proliferation Adaptive Immune Response CD8-positive, Alpha-beta T Cell Differentiation Involved In Immune Response Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Apoptotic Process Movement Of Cell Or Subcellular Component Humoral Immune Response Cell Cycle Arrest Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Response To Virus Cytokine-mediated Signaling Pathway Antigen Processing And Presentation Neutrophil Chemotaxis Negative Regulation Of Epithelial Cell Differentiation Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Myelination Positive Regulation Of Synaptic Transmission, Cholinergic Negative Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Smooth Muscle Cell Apoptotic Process Positive Regulation Of T Cell Proliferation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Growth Of Symbiont In Host Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Insulin Secretion Sensory Perception Of Mechanical Stimulus Positive Regulation Of Membrane Protein Ectodomain Proteolysis Defense Response To Virus Positive Regulation Of Killing Of Cells Of Other Organism Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Fructose 1,6-bisphosphate 1-phosphatase Activity Positive Regulation Of Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Calcidiol 1-monooxygenase Activity Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-18 Negative Regulation Of Metanephric Nephron Tubule Epithelial Cell Differentiation Extrinsic Apoptotic Signaling Pathway Regulation Of Neuronal Action Potential Positive Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Regulation Of Hepatocyte Proliferation	Cell Surface Receptor Signaling Pathway Response To Virus Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Regulation of IFNG signaling
Drugs		Olsalazine Glucosamine	Interferon gamma-1b
Diseases
GWAS		Inflammatory bowel disease ( 23128233) Ulcerative colitis ( 20228799 21297633 19122664)	Crohn's disease ( 22936669 23128233) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: IFNGR1 IFNGR2 PDIA3 STAT6 TNF	8 interactors: ANXA5 CAMK2D DNAJA3 IFNG IFNGR1 JAK2 NR3C1 RPL37A
Entrez ID		3458	3460
HPRD ID		00957	00956
Ensembl ID		ENSG00000111537	ENSG00000159128
Uniprot IDs		P01579	A8K881 E7EUY1 P38484
PDB IDs		1EKU 1FG9 1FYH 1HIG 3BES
Enriched GO Terms of Interacting Partners?		Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Immune System Process Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Regulation Of Immune Response Response To Virus Positive Regulation Of Immunoglobulin Mediated Immune Response Immune Response Regulation Of Immune System Process Defense Response Response To Stress Epithelial Cell Proliferation Regulation Of Cytokine-mediated Signaling Pathway Cellular Response To Organic Substance Negative Regulation Of Branching Involved In Lung Morphogenesis Negative Regulation Of L-glutamate Transport Protein Import Into Nucleus Negative Regulation Of Immune Response Response To Other Organism Nuclear Import Interferon-gamma-mediated Signaling Pathway Response To Biotic Stimulus Positive Regulation Of Adaptive Immune Response Innate Immune Response Cellular Response To Interferon-gamma T-helper 1 Cell Lineage Commitment Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Response To Gold Nanoparticle Gland Morphogenesis Protein Import Response To Interferon-gamma Protein Localization To Nucleus Signal Transduction Response To Organic Substance Positive Regulation Of Interleukin-18 Production Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Mononuclear Cell Migration Sequestering Of Triglyceride Regulation Of Adaptive Immune Response Regulation Of Extrinsic Apoptotic Signaling Pathway Signaling Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Interleukin-4-mediated Signaling Pathway Positive Regulation Of Isotype Switching To IgE Isotypes Cell Communication	Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Response To Interferon-gamma Regulation Of Cytokine-mediated Signaling Pathway Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Regulation Of Innate Immune Response Response To Organic Substance Response To Cytokine Innate Immune Response Cytokine-mediated Signaling Pathway Regulation Of Heart Contraction Cellular Response To Cytokine Stimulus Immune Response Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Defense Response Positive Regulation Of Cell Death Positive Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Positive Regulation Of Phosphatase Activity Regulation Of The Force Of Heart Contraction Positive Regulation Of Interleukin-1 Production Regulation Of Cell Death Homeostasis Of Number Of Cells Regulation Of Signal Transduction Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Cell Proliferation Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Proteolysis Positive Regulation Of Cell Activation Regulation Of Signaling Regulation Of Immune Response Positive Regulation Of Dephosphorylation Regulation Of Interleukin-1 Beta Production Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Positive Regulation Of Tumor Necrosis Factor Production Establishment Of Protein Localization To Organelle Signal Transduction Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of JAK-STAT Cascade Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Regulation Of Steroid Biosynthetic Process Intracellular Steroid Hormone Receptor Signaling Pathway Signaling
Tagcloud ?		30min ancestry asks asleep habitual ifngr1 il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	allelic candidiasis cybb definition designation errors il12b il12rb1 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly
Tagcloud (Difference) ?		30min ancestry asks asleep habitual il10 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	allelic candidiasis cybb definition designation errors il12b il12rb1 immunological impair inborn intramacrophagic irf8 isg15 mendelian msmd mycobacteria nemo overt parasites penetrance perhaps physiologically predisposition recapitulate salmonellosis virulent weakly
Tagcloud (Intersection) ?		ifngr1