IFNG and STAT6

Number of citations of the paper that reports this interaction (PubMedID 9651359)
0

Data Source:
BioGRID (pull down)

		IFNG	STAT6
Description		interferon gamma	signal transducer and activator of transcription 6
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Cytokine Activity Type II Interferon Receptor Binding Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Phosphatase Binding Identical Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Cytokine Production Adaptive Immune Response Macrophage Activation Involved In Immune Response Positive Regulation Of T Cell Cytokine Production Apoptotic Process Immune Response Humoral Immune Response Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Response To Virus Positive Regulation Of Autophagy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Macrophage Differentiation Negative Regulation Of Epithelial Cell Differentiation Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Interleukin-17 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Involved In Immune Response Positive Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Positive Regulation Of Smooth Muscle Cell Apoptotic Process Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Interleukin-2-mediated Signaling Pathway Type III Interferon-mediated Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Astrocyte Activation Negative Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Positive Regulation Of Neurogenesis Regulation Of Insulin Secretion Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Transport Defense Response To Virus Type II Interferon-mediated Signaling Pathway Positive Regulation Of Fructose 1,6-bisphosphate Metabolic Process Positive Regulation Of Vitamin D Biosynthetic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Deacetylation Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Cellular Response To Virus Neuroinflammatory Response Negative Regulation Of Amyloid-beta Clearance Positive Regulation Of Glutamate Receptor Signaling Pathway Positive Regulation Of Cellular Respiration Positive Regulation Of Amyloid-beta Formation Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Exosomal Secretion Positive Regulation Of Iron Ion Import Across Plasma Membrane Positive Regulation Of Core Promoter Binding Positive Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production	Negative Regulation Of Transcription By RNA Polymerase II T-helper 1 Cell Lineage Commitment Negative Regulation Of Type 2 Immune Response Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Via JAK-STAT Gene Expression Cytokine-mediated Signaling Pathway Mammary Gland Epithelial Cell Proliferation Interleukin-4-mediated Signaling Pathway Regulation Of Cell Population Proliferation Response To Peptide Hormone Positive Regulation Of Transcription By RNA Polymerase II Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgE Isotypes Growth Hormone Receptor Signaling Pathway Via JAK-STAT Mammary Gland Morphogenesis Regulation Of Mast Cell Proliferation Positive Regulation Of Cold-induced Thermogenesis
Pathways		Interferon gamma signaling Regulation of IFNG signaling Regulation of IFNG signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation IFNG signaling activates MAPKs Differentiation of naive CD+ T cells to T helper 1 cells (Th1 cells)	Downstream signal transduction STAT6-mediated induction of chemokines Interleukin-4 and Interleukin-13 signaling
Drugs		Olsalazine Glucosamine VIR201 Fontolizumab Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal) Emapalumab
Diseases		Graft-versus-host disease Allograft rejection
GWAS		Alopecia areata ( 25608926) Anti-saccade response ( 29064472) Inflammatory bowel disease ( 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Systemic lupus erythematosus ( 28714469) Ulcerative colitis ( 19122664 20228799 21297633)	Adult asthma ( 30787307) Alcohol consumption ( 31358974) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Asthma ( 31619474 31361310 31959851 30929738 32296059 29273806 34103634 27182965) Asthma (adult onset) ( 30929738 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Bipolar disorder ( 31043756) Bitter alcoholic beverage consumption ( 31046077) Eosinophil count ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eosinophilic esophagitis ( 25407941) Eosinophilic esophagitis (pediatric) ( 20208534) Familial lung cancer ( 29924316) Headache ( 29397368) Height ( 31562340) IgE levels ( 22075330) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Medication use (adrenergics, inhalants) ( 31015401) Medication use (anti-inflammatory and antirheumatic products, non-steroids) ( 31015401) Medication use (antihistamines for systemic use) ( 31015401) Migraine ( 27322543) Migraine without aura ( 27322543) Mosquito bite size ( 28199695) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Sensory disturbances after bilateral sagittal split ramus osteotomy ( 23834954) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		5 interacting genes: IFNGR1 IFNGR2 PDIA3 STAT6 TNF	39 interacting genes: ANKZF1 ANXA2 CEBPB CEBPE CEBPZ CREBBP DAZAP2 EEF1A1 EP300 ETS1 FBXO7 H3C14 IFNG IL4R IRF4 JAK1 LITAF NCOA1 NCOA2 NFKB1 NMI PKNOX1 PPARG PRKCZ PTPN6 RCN3 RELA RLIM SND1 SRC STAT2 STAT3 TP53 TRIM24 VKORC1 WWP1 ZBTB2 ZNF407 ZNF92
Entrez ID		3458	6778
HPRD ID		00957	03302
Ensembl ID		ENSG00000111537	ENSG00000166888
Uniprot IDs		P01579	A8K4S9 B4DQB3 P42226
PDB IDs		1EKU 1FG9 1FYH 1HIG 3BES 6E3K 6E3L	1OJ5 4Y5U 4Y5W 5D39 5NWM 5NWX 9BIG
Enriched GO Terms of Interacting Partners?		Type II Interferon Receptor Activity Leukocyte Activation Involved In Inflammatory Response Microglial Cell Activation Macrophage Activation Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell Surface Receptor Signaling Pathway Via STAT Type III Interferon-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Amyloid-beta Clearance Myeloid Leukocyte Activation Type II Interferon-mediated Signaling Pathway Leukocyte Activation Astrocyte Activation Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation Cell Activation Positive Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Amide Metabolic Process Immune System Process Positive Regulation Of Immunoglobulin Mediated Immune Response Defense Response To Virus Regulation Of Amyloid-beta Formation Cell Surface Receptor Signaling Pathway Cytokine Receptor Activity Regulation Of Amyloid Precursor Protein Catabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Immunoglobulin Production Response To Virus Signal Transduction Interferon-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cellular Response To Virus Regulation Of Amide Metabolic Process Regulation Of Immunoglobulin Production Negative Regulation Of Bile Acid Secretion Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Response To External Biotic Stimulus Response To Peptide Response To Cytokine Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Extrinsic Apoptotic Signaling Pathway Tapasin-ERp57 Complex Defense Response Mammary Gland Morphogenesis Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus	Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Transcription By RNA Polymerase II Chromatin Regulation Of Immune System Process Nucleobase-containing Compound Biosynthetic Process Chromatin Binding Nucleus RNA Polymerase II Transcription Regulator Complex Macromolecule Biosynthetic Process Macromolecule Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Defense Response Transcription Regulator Complex RNA Metabolic Process Positive Regulation Of Gene Expression Negative Regulation Of RNA Metabolic Process Positive Regulation Of Defense Response MRNA Transcription DNA Binding Positive Regulation Of MiRNA Metabolic Process T Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Multicellular Organismal Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process T-helper 17 Cell Lineage Commitment DNA-binding Transcription Factor Activity Negative Regulation Of Biosynthetic Process
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